Detection Of Curcumin Research Articles

Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin.

Curcumin (CUR), a polyphenolic substance from turmeric, displays diverse medicinal properties. However, its instability poses challenges in detection. Cyclodextrin-based nanogels (CyDngs) offer a transformative solution, enhancing CUR's stability in aqueous solutions. Multisensing approaches involving fluorescence, electrochemistry, and NMR spectroscopy were employed, demonstrating CyDngs' pivotal role in CUR detection. Langmuir analysis revealed a binding constant of 1.4 × 104 M-1 for CyDngs, highlighting their effectiveness over native β-CyDs. The study emphasized CyDngs' superiority in stabilizing CUR and enabling reliable and sensitive detection with very diverse methods.

Selective modified stripping voltammetric sensor based on Ce-1,4-benzenedicarboxylic metal–organic frameworks porous nanoparticles for picomolar detection of curcumin

• Porous Ce-BDC MOF nanoparticles were fabricated via the solvothermal method. • A modified stripping voltammetric sensor was fabricated with 1.0% Ce-BDC. • The sensor showed remarkable conductivity and electrocatalytic activity. • Low detection limits and a wide linearity range detection of curcumin were measured. • The sensor detected both co-mixed CUR and PIP concentrations without interference. A modified stripping voltammetric sensor based on porous nanoparticles from a Ce-1,4-benzenedicarboxylic (Ce-BDC) metal–organic framework (MOF) has been successfully fabricated for the detection of curcumin (CUR). Fabrication of porous nanoparticles of Ce-BDC acid MOF was carried out via the solvothermal method. The resulting MOF emerges with good crystallinity, octahedral-like morphology, and a specific surface area of 1020 m 2 g −1 , leading to an increase in reaction sites for the sensorand further enhanced performance. Cyclic voltammetry measurements utilizing 1.0% Ce-BDC–modified graphite paste sensor (MGPS) demonstrated a remarkable improvement in electrocatalytic activity and adsorption performance. Under standard detection conditions, the MGPS possessed a low limit of detection of 6 pM and wide linearity ranges of 0.02–2.0 (6.67 μA·nM −1 ) and 2.0–9.0 nM(1.65 μA·nM −1 ) for CUR using the square wave anodic stripping voltammetry method. Furthermore, the MGPS reveals proper accuracy, reproducibility, and storage stability, as well as anti-interference ability during the detection of CUR in biological fluids. The modified stripping voltammetric sensor was able to detect both co-mixed CUR and piperine concentrations, without interference during the analysis process.

Electro-Polymerized Titan Yellow Modified Carbon Paste Electrode for the Analysis of Curcumin

A modest, efficient, and sensitive chemically modified electrode was fabricated for sensing curcumin (CRC) through an electrochemically polymerized titan yellow (TY) modified carbon paste electrode (PTYMCPE) in phosphate buffer solution (pH 7.0). Cyclic voltammetry (CV) linear sweep voltammetry (LSV) and differential pulse voltammetry (DPV) approaches were used for CRC detection. PTYMCPE interaction with CRC suggests that the electrode exhibits admirable electrochemical response as compared to bare carbon paste electrode (BCPE). Under the optimized circumstances, a linear response of the electrode was observed for CRC in the concentration range 2 × 10−6 M to 10 × 10−6 M with a limit of detection (LOD) of 10.94 × 10−7 M. Moreover, the effort explains that the PTYMCPE electrode has a hopeful approach for the electrochemical resolution of biologically significant compounds. Additionally, the proposed electrode has demonstrated many advantages such as easy preparation, elevated sensitivity, stability, and enhanced catalytic activity, and can be successfully applied in real sample analysis.

Development of carbon nanotube-based polymer-modified electrochemical sensor for the voltammetric study of Curcumin

ABSTRACT The applicability of Curcumin (CRC) as a medicinal remedy for various health issues and as an anti-inflammatory agent, it is of great importance to develop an effortless, sensitive methodology for its determination. In the present research, CRC was determined electrochemically via voltammetric techniques using poly(L-arginine) modified carbon nanotube paste sensor (PArMCNTPS). Different parameters (pH, scan rate, number of polymerisation cycle) were optimised using cyclic voltammetry. CRC displayed well-defined oxidative and reductive peaks at 0.24 V and 0.16 V, respectively. The efficacy of the electrode towards the concurrent detection of CRC was examined in the presence of Riboflavin and Ascorbic acid. Detection of CRC by PArMCNTPS through differential pulse voltammetry technique was achieved from 2 × 10−7 M to 5 × 10−6 M and it presents adequately low detection (6.62 × 10−8 M) and quantification (2.20 × 10−7 M) limits. Furthermore the developed sensor was employed to determine CRC in turmeric powder to validate its analytical application.

Composite polymerized molecular imprinting membrane-based electrochemical sensor for sensitive determination of curcumin by using 4-pentenoyl-aminoacyl-chitosan oligosaccharide as functional monomer oligomer

In this work, 4-pentenoyl-alanyl-chitosan oligosaccharide (PACO), a functional oligomer of chitosan oligosaccharide with the strong affinity on curcumin (CUR), was screened from the series of 4-pentenoyl-aminoacyl-chitosan oligosaccharides through the results of computational selection. After the preparation of this oligomer, a novel molecular imprinting membrane-based electrochemical sensor was developed for sensitive detection of CUR. The molecularly imprinted membrane (MIM) of CUR was obtained by composite compensation polymerization process: bulk polymerization with good permeability on a glassy carbon electrode (GCE) surface by using CUR as the template molecule, PACO as the oligomer of functional monomer and ethylene glycol dimethacrylate as the crosslinking agent, followed by electrochemical polymerization with good sensitivity in methylene bisacrylamide solution. After removing the template molecule, the modified electrode could specifically adsorb CUR molecules. Under optimal conditions, the sensor named as CUR-MIM/GCE exhibited high sensitivity and good selectivity against some analogs of CUR such as tetrahydrocurcumin, ferulic acid, β-carotene, and quercetin. The calibration graph of the designed sensor was linear in the range of 10 nM to 2.0 μM with a detection limit of 5.0 nM. This sensor showed excellent selectivity and good reproducibility, and more than 90% of its original response was retained after storage in a sealed capsule at room temperature for 30 days. Moreover, the constructed sensor was successfully applied to monitor the CUR contents in turmeric extract with the relative standard deviation of less than 3.3%.

Spectrofluorometric Method Development and Validation for the Determination of Curcumin in Nanoliposomes and Plasma.

In this paper, we have reported a rapid, simple, sensitive, straightforward, and validated method for the concentration determination of curcumin (CUR) in nanoliposomes and plasma using the spectrofluorimetry. For both nanoliposomal formulation and plasma, methanol was used as a solvent to extract the CUR. The excitation and emission wavelengths were set at 423nm and 527nm, respectively. The method validation was performed based on International Council for Harmonization (ICH) guidelines, Q2, in which parameters; such as, linearity, precision, accuracy and etc., were determined. The results showed that the calibration curve was linear for CUR concentrations of 0.05 to 0.5μg /mL with a correlation coefficient of 0.9996. The limit of detection (LOD) and limit of quantification (LOQ) were 0.03 and 0.10μg/mL, respectively. Liposomal CUR (15mg/kg) was injected intravenously to mice, and at certain time intervals (1, 3, 6, and 24h), blood samples were collected. The samples were extracted by methanol and CUR concentrations were detected using a fluorescence spectrophotometer. Results indicated the rate of liposomal formulation decline was slower than free CUR. The results of this study indicated that the validation method based on fluorimetry which was developed here is reliable for the detection of CUR in liposomal formulations and plasma.

Urazole-Au Nanocluster as a Novel Fluorescence Probe for Curcumin Determination and Mitochondria Imaging

Curcumin (CUR), a natural plant product, is widely used in food and medicine. The determination of CUR in medicine and food will be important to control the quality of CUR containing products. Herein, a new kind of fluorescence urazole-Au clusters (Urazole-AuNCs) has been synthesized successfully via one-step method using urazole and polyvinyl pyrrolidone (PVP) as templates. The fluorescence emission intensity of Urazole-AuNCs at 473 nm is sensitive to the concentration of CUR. Therefore, a fluorescence method for the quantitative detection of CUR was built using Urazole-AuNCs as the fluorescence sensor with detection limit of 72 nM. This method was successfully used to quantitatively monitor CUR in curry powder; Urazole-AuNC-based fluorescence method can be a good technique for quantitative detection of CUR and differentiation of CUR from others. Furthermore, the novel low-toxic urazole-Au clusters could be used for mitochondrial targeted imaging of cancer cells.