Abstract
Curcumin (CUR), a natural plant product, is widely used in food and medicine. The determination of CUR in medicine and food will be important to control the quality of CUR containing products. Herein, a new kind of fluorescence urazole-Au clusters (Urazole-AuNCs) has been synthesized successfully via one-step method using urazole and polyvinyl pyrrolidone (PVP) as templates. The fluorescence emission intensity of Urazole-AuNCs at 473 nm is sensitive to the concentration of CUR. Therefore, a fluorescence method for the quantitative detection of CUR was built using Urazole-AuNCs as the fluorescence sensor with detection limit of 72 nM. This method was successfully used to quantitatively monitor CUR in curry powder; Urazole-AuNC-based fluorescence method can be a good technique for quantitative detection of CUR and differentiation of CUR from others. Furthermore, the novel low-toxic urazole-Au clusters could be used for mitochondrial targeted imaging of cancer cells.
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