Curative Effect In Treatment Group Research Articles

Effects of Kangfuxin solution on IL-1β, IL-6, IL-17 and TNF-α in gingival crevicular fluid in patients with fixed orthodontic gingivitis.

Changes of interleukin (IL)-1β, IL-6, IL-17 and tumor necrosis factor-α (TNF-α) in gingival crevicular fluid in patients with fixed orthodontic gingivitis after treatment with Kangfuxin solution were analyzed to explore the clinical effect of Kangfuxin solution in patients with orthodontic gingivitis. A total of 78 patients diagnosed with fixed orthodontic gingivitis in Weifang People's Hospital from January 2015 to March 2017 were selected. Thirty-nine patients were treated with gingival cleansing as control group, and the other 39 patients were treated with gingival cleansing plus spraying and sublingual administration with Kangfuxin solution as treatment group. The general data of patients were collected, and the changes of IL-1β, IL-6, IL-17 and TNF-α in gingival crevicular fluid were measured, the bleeding index (BI), probing depth (PD), swelling and pain grades were recorded, and the clinical curative effects were compared between the two groups. The curative effect in treatment group was better than that in control group (p<0.05). After treatment, gingival BI and PD in both groups were lower than those before treatment. The curative effect in treatment group was better than that in control group (p<0.05). The levels of gingival pain and swelling after treatment in treatment group were mainly in grade I. The levels of gingival pain and swelling after treatment in control group were mainly in grade II and III (p<0.05). After treatment, the effective rate of control group was 76.92% and that of treatment group was 97.44% (p<0.05). It was found that the levels of IL-6 and TNF-α in gingival crevicular fluid were positively correlated with PD. The use of Kangfuxin solution in the treatment of patients with orthodontic gingivitis can effectively reduce the levels of IL-1β, IL-6, IL-17 and TNF-α in gingival crevicular fluid, and improve the periodontal conditions and the effective rate of treatment.

The effects of atorvastatin on interventional therapy in patients with acute myocardial infarction.

The aim of this study was to analyze the changes of interleukin-6 (IL-6), C-reactive protein (CRP), blood lipids and myocardial indexes after treatment of patients with acute myocardial infarction (AMI) with intensive atorvastatin and interventional therapy, and its clinical significance. A total of 78 patients diagnosed with AMI in our hospital from March 2016 to February 2017 were selected and divided into treatment group (N.=39) and control group (N.=39). Patients in treatment group were treated with intensive atorvastatin based on conventional therapy before and after percutaneous coronary intervention (PCI), while those in control group were treated with conventional therapy before and after PCI. The levels of serum IL-6, CRP, blood lipids (total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C] and low-density lipoprotein cholesterol [LDL-C]) and myocardial enzyme indexes (troponin T [TnT] and creatine kinase-MB [CK-MB]) at different time points were detected. The correlations among serum CRP, TC, and TnT in treatment group before treatment were detected using the linear regression analysis, and changes in serum inflammatory factors, blood lipids and myocardial enzyme indexes in treatment group before and after treatment were analyzed. There were no statistically significant differences in demographics and clinical data between treatment group and controls (P>0.05). There were no significant differences, either, in levels of serum IL-6 and CRP before treatment between treatment group and control group, but they were decreased after treatment, and the curative effect in treatment group was significantly superior to that in control group. The differences were statistically significant (P<0.05). There were no significant differences in serum TC, TG, HDL-C and LDL-C levels before treatment between the two study groups. TC, TG and LDL-C were significantly decreased and HDL-C was significantly increased after treatment compared to before treatment. TnT and CK-MB were significantly increased at 24 hours after treatment (P<0.05). At 1 week, TnT was still higher, whereas CK-MB has returned to normal; at 2 weeks, they were both decreased. The curative effect in the treatment group was significantly superior to that in control group. CRP (r=0.793, P<0.001) and TC (r=0.668, P<0.001) were found to be positively correlated with TnT. The levels of serum inflammatory factors and blood lipids in the treatment group before treatment and at 24 hours, 1 week, and 2 weeks showed a decreasing trend, and TnT was increased at first, and then decreased. The application of intensive atorvastatin for AMI patients, especially before PCI, has high safety, which can effectively reduce levels of serum inflammatory factors and blood lipids, protect myocardial cells after PCI and avoid injury.

瞳神紧小方治疗前葡萄膜炎风湿夹热型的临床观察

目的：观察瞳神紧小方对风湿夹热型急性前葡萄膜炎患者临床疗效。方法：将诊断为风湿夹热型急性前葡萄膜炎患者60例，随机分为对照组和治疗组，治疗组予瞳神紧小方、美多丽和典必殊治疗，对照组仅予美多丽和典必殊治疗。随访观察2周，比较2组疗效。结果：1) 视力疗效：治疗一周、二周，治疗组视力有效率分别为86.67%、96.6%，对照组视力有效率分别为60%、83%。治疗一周、二周后组间差异有统计学意义(P Objective: To observe the clinical effect of Tongshenjinxiao prescription for acute anterior uveitis with syndrome of wind heat dampness. Methods: Sixty patients (60 eyes) of acute anterior uveitis with syndrome of wind heat dampness were randomly divided into control group and treatment group as research object according to the diagnostic criteria. The treatment group was treated with Tongshenjinxiao prescription, tropicamide phenylephrine eye drops and tobradex eye drops. The control group was treated with tropicamide phenylephrine eye drops and tobradex eye drops. Follow up observation lasted for 2 weeks, the effects of the 2 groups were compared. Result: 1) The curative effect of vision: After 1 week and 2 weeks, the vision efficiency of the treatment group was 60% and 83% respectively while the counterpart of control group was 60% and 83%. 1 week and 2 weeks after treatment, the difference between groups was statistically significant (P < 0.05). 2) Anterior segment sign: 1 week and 2 weeks after treatment, the treatment group was superior to the control group in improving the ciliary congestion, posterior corneal sediment, aqueous humor and planktonic cell signs. The difference between groups was statistically significant (P < 0.05). 3) The curative effect of TCM syndrome: after 1 week, 2 weeks, the total effective rate of the treatment group was 93.33% and 93.33% respectively while the results of control group was 63.33% and 73.33%. At each time point, the curative effect in treatment group was better than that in control group (P < 0.05). Conclusion: Tongshenjinxiao prescription was used to treat acute anterior uveitis with syndrome of wind heat dampness. It could significantly improve the anterior segment signs, visual acuity and relieve symptoms of wind heat dampness.

Effect of High-dose Mucosolvan applied to the patients with severe pneumonia during mechanical ventilation

Objective To test the effe.cts of high-dose mucosolvan on the patients with severe pneumonia during mechanical ventilation.Method Sixty patients aged from 20 to 65 with severe pneumonia during mechanical ventilation from January 2011 to December 2012 at Shantou Central Hospital were randomized to treatment group and control group.Both groups were applied to antibiotics,mechanical ventilation and supportive care.The treatment group was administered continuous-infusion (CI) schedules of mucosolvan(20mg/kg each day) in three hours and the control group was administered Intravenous injection of mucosolvan(60mg each day).The lung injury score(LIS),PaO2,PaO2/FiO2,lung compliance,peak inspiratory pressure(PIP),airway resistance(RAW),prolonged mechanical ventilation,length of stay in intensive care unit(ICU) and 4-week survival rate were analyzed.Result The curative effect of treatment group is better than the control group(P ＜ 0.05).In contrast,there is no difference in the 4-week survival rate between the treatment group and the control group(P ＞ 0.05).Conclusion High-dose mucosolvan may improve clinical outcome in the treatment of patients with severe pneumonia during mechanical ventilation. Key words: Mucosolvan; Severe pneumonia; Mechanical Ventilation

The clinical observation of gongliuxiao combined with mifepristone in the treatment of uterine fibroids

Objective To explore the clinical curative effect of treating peptic ulcer by rabeprazole joint clarithromycin and amoxicillin.Methods 80 cases were divided randomly into control group and observation group.Patients in the control group were given mifepristone,patients in the treatment group were given gongliuxiao on the base of the control group,after one course of treatment,the clinical curative effects of the two groups were evaluated.Results The clinical effective rate of the control group and observation group was 72.5 ％ and 92.5 ％,respectively,the curative effect of treatment group was significantly better than that of control group (x2 =5.600,P ＜ 0.01).Conclusion The clinical curative effect of treating uterine fibroids by gongliuxiao combined with mifepristone is distinct,safe and reliable. Key words: Leiomyoma; Gongliuxiao; Mifepristone

Influence on hemorheology of cervical spondylopathy with Xi (cleft) point electroacupuncture

Objective: To observe the curative effect of Xi (Cleft) point electro-acupuncture on acute cervical spondylopathy of blood stasis type.Methods: 32 cases of acute spondylopathy of blood stasis type were treated with electroacupuncture on Huizong (TE 7) point, Xi (Cleft) point of Triple Energizer Meridian of Hand Shaoyang and Yanglao (SI 6) point, Xi (Cleft) point of Small Intestin Meridian of Hand Taiyang. 31 cases were randomly selected as the research subjects for control group and treated with routine treatment. At the same time changes of hemorheology were observed in the two groups before and after treatment. VAS was used for pain evaluation.Results and conclusion: The total curative effect in treatment group was 93.8%, the average duration of course 20.2±3.1d, pain accumulation points 3.47±1.45; The total curative effect in contrast group was 83.9%, the average duration of course 26.5±1.8 d, pain accumulation points 5.67±1.52.P<0.01 after t test. Ridit analysis was used for analysis of the therapeutic effect.P<0.05. There were some improvements in hemorheology in the two groups before and after treatment. It showed that there was a significant difference in the two groups in therapeutic results and average duration of course. The therapeutic results were improved and duration of course shortened in the treatment group.