Effect of High-dose Mucosolvan applied to the patients with severe pneumonia during mechanical ventilation

Abstract

Objective To test the effe.cts of high-dose mucosolvan on the patients with severe pneumonia during mechanical ventilation.Method Sixty patients aged from 20 to 65 with severe pneumonia during mechanical ventilation from January 2011 to December 2012 at Shantou Central Hospital were randomized to treatment group and control group.Both groups were applied to antibiotics,mechanical ventilation and supportive care.The treatment group was administered continuous-infusion (CI) schedules of mucosolvan(20mg/kg each day) in three hours and the control group was administered Intravenous injection of mucosolvan(60mg each day).The lung injury score(LIS),PaO2,PaO2/FiO2,lung compliance,peak inspiratory pressure(PIP),airway resistance(RAW),prolonged mechanical ventilation,length of stay in intensive care unit(ICU) and 4-week survival rate were analyzed.Result The curative effect of treatment group is better than the control group(P ＜ 0.05).In contrast,there is no difference in the 4-week survival rate between the treatment group and the control group(P ＞ 0.05).Conclusion High-dose mucosolvan may improve clinical outcome in the treatment of patients with severe pneumonia during mechanical ventilation. Key words: Mucosolvan; Severe pneumonia; Mechanical Ventilation