Cumulative Percentage Research Articles

Mucoadhesive Buccal Tablet Formulation of Azithromycin dihydrate for treatment of Upper Respiratory Tract Infection

The buccal drug delivery system is a versatile delivery system which can be designed for local or systemic effect. The objective of the study was to developed patient complacent tablet which can give sustain release of antibacterial agent for relief of upper respiratory tract infection. Azithromycin dihydrate is a semi-synthetic macrolide antibiotic widely used to prevent bacterial infections in the upper respiratory tract. The mucoadhesive buccal tablets of azithromycin dihydrate were formulated by varying concentrations of polymers (natural and synthetic), glidant and other excipients. The drug-excipient compatibility studies were carried out through DSC and FTIR studies. The selected excipients were found to be compatible. Further the dry blend of drug-excipients was evaluated for pre-compression properties. The prepared tablets were evaluated as per the general monograph for tablets of IP. The studies were also carried out to evaluate sustained release of the drug and mucoadhesivity of the tablets. A 23 level (2 level and 3 factors) factorial design was navigated to study the effect of natural, synthetic polymers and the glidant on mucoadhesive strength and percentage cumulative drug release at 8 hours. The responsive variables were analysed using ANOVA by Design-Expert version 12.0. It was concluded that these excipients significantly affected the response variables. The optimized tablet formulation was found to have an adequate mucoadhesion and a cumulative percentage release. The final product was performed for accelerated stability studies, optimized formulation was found to be stable at room temperature and accelerated temperature for three months.

Surface-enhanced raman spectroscopy with machine learning in non-invasive detection of dengue-NS1 fingerprint

The surface-enhanced Raman spectroscopy (SERS) method exploits the plasmonic effect of nano-sized metallic materials to intensify the Raman scattering of the monochromatic light of analyte molecules. This promotes the sensitivity and specificity of the Raman spectroscopy analysis method. This study integrated SERS with machine learning (ML) to detect dengue fever, a disease infecting more than 40% of the world’s population. Non-structural protein 1 (NS1), detected in the sera of infected dengue patients during the early infection stage, is currently recognised as a biomarker for the early diagnosis of DF. However, no attempts have been made to detect NS1 in the salivary Raman spectra. Given this situation, this study delves into the potential of SERS as an early, non-invasive DF detection technique using salivary NS1. The SERS spectra of saliva samples (n=289) were collected and subsequently classified as positive and negative for DF, using principal component analysis (PCA) integrated with support vector machine (SVM) models. The PCA-SVM model's performance was benchmarked against two clinical diagnostic NS1-enzyme-linked immunosorbent assay (ELISA) tests recommended by the World Health Organization (WHO). The PCA-SVM model outperformed both tests regarding radial basis function kernel (RBF) and cumulative percent variance (CPV; 83.22% accuracy, 88.27% sensitivity, 78.13% specificity). It is encouraging that the sensitivity level of the PCA-SVM model is above the benchmark set by the saliva-based NS1-ELISA tests proposed by the WHO, demonstrating the potential of SERS for the non-invasive detection of DF.

Sustained-release nitrogen fertilizer delivery systems based on carboxymethyl cellulose-grafted polyacrylamide: Swelling and release kinetics

Sustained or controlled-release delivery systems can enhance functions such as nutrient usage; minimize soil contamination, and reduce the required fertilizer dose. This paper reports the development of a carboxymethyl cellulose-g-polyacrylamide copolymer (CMC-g-PAM) as a sustained and slow-release fertilizer carrier for urea. The developed copolymer was characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and thermo gravimetric analysis (TG). The grafting process increased the activation energy of CMC from 0.1521 to 0.5952 J/mol with a higher loading percentage of 72.140.85% using a 15% urea solution. The swelling ratio is significantly dependent on the pH. The maximum swelling ratio of 1199.58% at pH 9. However, Swelling follows a pseudo-first-order reaction with the maximum swelling ratio in a saline of 349.76%.The CMC-g-PAM copolymer loaded with urea exhibited sustained and slow release, with the maximum cumulative percentage of 69.12% at pH 9 and 38.94% in saline. Urea release from the CMC-g-PAM copolymer followed the first-order, Fickian, and biexponential biphasic release mechanisms. The release of the CMC-g-PAM copolymer loaded with urea is a complicated process governed by diffusion and a biphasic releasing profile.

A comparison of cemented femoral fixation via anterior versus posterior approach total hip arthroplasty: an analysis of 60,739 total hip arthroplasties.

Anterior approach total hip arthroplasty (THA) decreases the rate of dislocation but increases femoral-sided complications in the way of periprosthetic fractures and component loosening. A cemented prosthesis may reduce femoral-sided complications and improve the risk:benefit profile of anterior approach THA. Data from the Australian National Joint Replacement Registry were analysed for patients undergoing primary THA via the anterior or posterior approach using a cemented polished femoral stem from January 2015 to December 2021. The primary outcome measure was the cumulative percent revision (CPR) for all causes and CPR for femoral component loosening and fracture. The CPR for the primary outcome measures were compared between the anterior and posterior approach and adjusted for age, sex, ASA score, BMI and femoral head size. The study included 60,739 THAs with cemented stems (10,742 anterior, 49,997 posterior). The rate of revision of the anterior versus the posterior approach did not significantly differ (HR 0.87 (95% CI, 0.74-1.03), p = 0.100). Anterior approach THA had a significantly higher rate of revision for femoral component loosening (HR 5.06 [95% CI, 3.08-8.30], p < 0.001); and a decreased rate of revision for infection (HR 0.59 [95% CI, 0.43-0.81], p = 0.001) and dislocation/instability (HR 0-3 months 0.48 [95% CI, 0.27-0.83], p = 0.008; HR >3 months 0.30 [95% CI, 0.15-0.61], p < 0.001). There was no difference in the rate of revision surgery for fracture between the 2 approaches (HR 1.01 [95% CI, 0.71-1.43]), p = 0.975). There is no significant difference in overall revision rates with cemented femoral fixation performed with an anterior or posterior approach. Cemented fixation performed with the anterior approach partly mitigates femoral complications with no difference in the revision rate for fracture but an increased rate of femoral component loosening.

Sirolimus experience in adult patients with vascular malformations.

Sirolimus, a mammalian target of rapamycin inhibitor, inhibits cell growth and proliferation by controlling ribosome biogenesis and protein synthesis in vascular anomalies and cancers. However, most sirolimus studies on vascular anomalies were conducted in the pediatric population, with limited data in adults. In this study, we assessed the effectiveness and safety of sirolimus in adult patients with vascular malformation, a subtype of vascular anomaly. We conducted a retrospective analysis of adult vascular malformation patients aged over 16, treated at Hacettepe University Cancer Institute from January 2013 to September 2022. Patient demographics and clinical characteristics were recorded. The primary outcome was the efficacy of sirolimus evaluated by response and disease control rates. The disease control rate was defined as the cumulative percentage of complete or partial responses, along with stable disease. The secondary endpoint was toxicity and safety. 38 patients with a median age of 21 (IQR: 18-33) were recruited. Prior to sirolimus treatment, 57.9% of patients had undergone other therapeutic interventions, predominantly sclerotherapy and surgery. The median follow-up time during sirolimus treatment was 18.5 (IQR: 11.3-74.5) months. The disease control rate was 92.1% (35/38). Head-neck localization was associated with better response rates (p = .001). Sirolimus was generally well tolerated and grade 1 or 2 oral mucositis (n = 4) and skin rash (n = 3) were the most common side effects. In this study, we found sirolimus was efficacious and well tolerated in adult patients with vascular malformation.

Study on the fabrication and performance of hierarchical porous 3D printed PCL-based artificial bone scaffold with anti-bacterial effect

Nonunion and large bone defects caused by trauma, tumor resection, and other bone diseases pose great challenges for clinical treatment. In this work, we fabricated a hierarchical porous scaffold mimicking the natural bone in structure and component. The inner MC/PCL/VCM (MCP-V) scaffold with pore sizes of 10–30 μm was prepared by vacuum freeze-drying, which has drug loading and mimics the bone component and structure. Then outer PT scaffold with pore sizes of 400–500 μm was prepared and a hole reserved for embedding the prepared MCP-V scaffold by 3D printing. The results showed that the compressive strength increased from 1.6 ± 0.01 MPa to 11.0 ± 0.38 MPa, and the compressive modulus increased from 1.1 ± 0.40 MPa to 12.4 ± 0.42 MPa, separately. As the variation of porosity for scaffolds, the cumulative drug release percentage decreased from (55.3 ± 1.43) % to (44.3 ± 2.47) % at 6 days. Furthermore, CCK-8 and the Live/Dead assay were utilized to assess the viability of MC3T3-E1 cells on scaffolds, which revealed no significant cytotoxicity. The hierarchical scaffold meets the mechanical requirement of cancellous bone, with slow drug release properties and excellent cytocompatibility, providing an effective repair strategy for clinical bone defects.

Characteristics associated with rerevision of primary inlay and onlay reverse shoulder arthroplasty. Analysis from the Australian Orthopaedic Association National Joint Replacement Registry

BackgroundTwo designs of primary reverse total shoulder arthroplasty (rTSA), inlay reverse total shoulder arthroplasty (in-rTSA) and onlay reverse total shoulder arthroplasty (on-rTSA) that had undergone an aseptic revision were compared to determine differences in the rate of rerevision. MethodsIn this comparative observational national registry study between January 1, 2012, and December 31, 2021, all rTSA utilizing either a modular inlay or onlay metaphyseal humeral component that had been revised for aseptic reasons formed 2 cohort groups. The cumulative percentage rerevision (2nd CPR) was determined using Kaplan-Meier estimates of survivorship and hazard ratios (HRs) from Cox proportional hazard models adjusted for age and sex. A minor category revision involved exchange of parts not fixed to bone whilst major revisions did. The primary and revision diagnoses, surgeon primary volume experience, and revision category were compared. Shoulder Modular Replacement (SMR)/SMR L1 or L2 combination (Lima Corporate, San Daniele del Friuli, Italy) was excluded at subanalysis. ResultsThe 2nd CPR at 3 years was 20.4% (95% confidence interval 17.1, 24.1) for in-rTSA (n = 571) and 16.1%(11.6, 22.2) for on-rTSA (n = 249). The risk of rerevision was not different between the 2 cohort groups. Primary diagnosis fracture was associated with an increased risk of rerevision for on-rTSA (entire period on-rTSA HR = 3.16(1.50, 6.68), P = .002), and in-rTSA at subanalysis (entire period on-rTSA HR = 2.91(1.33, 6.33), P = .007). 59.9% of in-rTSA and 24.1% of on-rTSA aseptic revisions were minor. The revision diagnosis, the surgical experience of rTSA and if the revision was major or minor did not change the rate of rerevision. The most common reason for both in-rTSA (50%) and (43.2%) on-rTSA rerevision was instability/dislocation. DiscussionRerevision rates of in-rTSA and on-rTSA after aseptic revision are high. The primary rather the revision diagnosis changed rerevision rates in contemporary rTSA surgery. Minor revisions did not reduce rerevision rates for in-rTSA or on-rTSA compared to humeral/glenoid revision. Increased surgical experience of primary rTSA did not change the rate of rerevision of in-rTSA or on-rTSA.

Fabrication, evaluation, and enhanced penetration of vinyl and cellulose-engineered transdermal patch of nifedipine using essential oil as penetration enhancer

The aim of this study was to develop and evaluate the transdermal patch formulations of nifedipine. The patch formulations containing nifedipine were prepared and optimized with different ratios of vinyl and cellulose-derived polymers, drug contents, and permeation enhancers. Among the various formulations, the patch formulation containing a 1:5 ratio of ethyl cellulose and polyvinyl pyrrolidone was selected for ex vivo pharmacokinetic study based on in vitro permeation studies using stratum corneum of the pig’s skin. The cumulative percentage release after the transdermal administration of the optimized patch formulation was 71.43%, and the plasma concentration of nifedipine was maintained for 16 hrs. The physicochemical evaluation study including flatness, thickness, moisture content and uptake, drug content in vitro release, and ex vivo permeation indicated satisfactory results. The formulation batch with clove oil as a penetration enhancer has shown better ex vivo permeation as compared to the formulations without enhancers and another synthetic enhancer. These results suggest that the optimized patch formulation Q3 could be further developed for clinical applications, providing the therapeutic plasma level of nifedipine over an extended period. Hence analyzing the results of the evaluation tests, in vitro and ex vivo data on the preparation and optimization of nifedipine-loaded transdermal patch, it can be concluded that the formulation shows its feasibility as an effective transdermal delivery system for nifedipine.

Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis.

Psoriasis is a complex and persistent autoimmune skin disease. The present research focused on the therapeutic evaluation of betulin-loaded nanostructured lipid carriers (BE-NLCs) towards managing psoriasis. The BE-NLCs were synthesized using the emulsification cum solidification method, exhibiting a spherical shape with a particle size of 183.5±1.82nm and a narrow size distribution window (PDI: 0.142±0.05). A high zeta potential -38.64±0.05mV signifies the relative stability of the nano-dispersion system. BE-NLCs show a drug loading and entrapment efficiency of 47.35±3.25% and 87.8±7.86%, respectively. In vitro release study, BE NLCs show a cumulative percentage release of 90.667±5.507% over BE-sol (57.334±5.03%) and BD-oint (42±4.58%) for 720min. In an ex vivo 24-h permeation study, % cumulative amount permeated per cm2 was found to be 55.667±3.33% from BE-NLCs and 32.012±3.26% from BE-sol, demonstrating a better permeability of 21.66% when compared to the standard formulation BD-oint. The in vivo anti-psoriatic activity in the IMQ-induced model shows topical application of BE-sol, BE-NLCs, and BD-oint resulted in recovery rates of 56%, 82%, and 65%, respectively, based on PASI (Psoriasis Area and Severity Index) score. Notably, BE-NLCs demonstrated a more significant reduction in spleen mass, indicating attenuation of the local innate immune system in psoriatic mice. Reductions in TNF-α, IL-6, and IL-17 levels were observed in both BE-sol and BE-NLCs groups compared to the disease control (DC) group, with BE-NLCs exhibiting superior outcomes (74.05%, 44.76%, and 49.26% reduction, respectively). Soy lecithin and squalene-based NLCs could be better carrier system for the improvement of the therapeutic potential of BE towards management of psoriasis.

Determinan Minat Mahasiswa Menggunakan QRIS sebagai Alat Pembayaran Digital (Studi pada Mahasiswa GENBI Bengkulu)

The aim of this research is to analyze the factors that influence GENBI Bengkulu students' interest in using QRIS as a digital payment tool. The type of research used was an ex post facto quantitative method with a proportional sampling technique and the results obtained were 86 samples from a total of 200 existing populations. The data analysis technique uses factor analysis calculations using the SPSS program with the Bartlett's Test of Spherecity analysis technique. The research results showed that 3 factors were obtained which were factors that influenced GENBI Bengkulu students' interest in using QRIS, namely financial literacy, ease of use, and benefits. The cumulative percentage of variance from the extracted factors is 68.22%, which means that the results of the research formed are able to explain the factors that influence GENBI Bengkulu students' interest in using QRIS, and the most dominant factor in this research is the financial literacy factor.

Comparing Neuromuscular Blockade Measurement Between Upper Arm (TOF Cuff®) and Eyelid (TOF Scan®) Using Mivacurium during General Anesthesia.

BACKGROUND Mivacurium is a non-depolarizing neuromuscular blocking agent. TOF-Cuff® is a device that monitors intraoperative neuromuscular blockade and blood pressure. TOF-Scan® measures muscle relaxation status of an anaesthetized patient. This study included 36 patients aged 18 to 75 years presenting for elective surgery, to compare neuromuscular blockade measured using the TOF-Cuff of the upper arm and the TOF-Scan of the facial corrugator supercilii muscle during general anesthesia and following administration of mivacurium. MATERIAL AND METHODS Train-of-four (TOF) values were obtained every 30 s before intubation and successively every 5 min until extubation. RESULTS The median onset time for TOF-Cuff was longer than for TOF-Scan (210 s vs 90 s, P<0.00001). Multiplying the time to relaxation (according to TOF-Scan) by 1 to 8, respectively, provided concordance with the TOF-Cuff result for the following cumulative percentages of patients: 5.5%, 38.9%, 58.3%, 77.8%, 83.3%, 86.1%, 88.9%, and 91.7%. Analogue values for time to recovery from the last dose were 11.1%, 63.9%, 83.3%, 86.1%, 86.1%, 88.9%, 88.9%, and 91.7%. The proportion of patients who still had TOFratio=0 in the assessment performed at min 15 did not differ significantly between these 2 methods (P=0.088). Both TOF-Scan and TOF-Cuff showed a false-negative result in patients with clinical symptoms of preterm recovery; the numerical difference favored TOF-Cuff (1.6% vs 2.1%) but without statistical significance (P=0.2235). CONCLUSIONS When measurement on the limb is not possible, TOF-Scan on the eyelid can be an alternative for TOF-Cuff on the upper arm, if the time to relaxation is multiplied by at least 8, which is enough for 90% of patients.

Persistence and emergence of new neuropsychological deficits following SARS-CoV-2 infection: A follow-up assessment of the Geneva COVID-COG cohort.

Despite numerous observations of neuropsychological deficits immediately following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, little is known about what happens to these deficits over time and whether they are affected by changes in fatigue and any psychiatric symptoms. We aimed to assess the prevalence of neuropsychological deficits at 6-9 months and again at 12-15 months after coronavirus disease 2019 (COVID-19) and to explore whether it was associated with changes in fatigue and psychiatric symptoms. We administered a series of neuropsychological tests and psychiatric questionnaires to 95 patients (mean age = 57.12 years, standard deviation (SD) = 10.68; 35.79% women) 222 (time point 1 (T1)) and 441 (time point 2 (T2)) days on average after infection. Patients were categorised according to the severity of their respiratory COVID-19 symptoms in the acute phase: mild (no hospitalisation), moderate (conventional hospitalisation), and severe (hospitalisation in intensive care unit (ICU) plus mechanical ventilation). We ran Monte-Carlo simulation methods at each time point to generate a simulated population and then compared the cumulative percentages of cognitive disorders displayed by the three patient subgroups with the estimated normative data. We calculated generalised estimating equations for the whole sample to assess the longitudinal associations between cumulative neuropsychological deficits, fatigue, and psychiatric data (anxiety, depressive symptoms, posttraumatic stress disorder, and apathy). Most participants (>50%) exhibited a decrease in their neuropsychological impairments, while approximately 25% showed an escalation in these cognitive deficits. At T2, patients in the mild subgroup remained free of accumulated neuropsychological impairments. Patients with moderate severity of symptoms displayed a decrease in the magnitude of cumulative deficits in perceptual and attentional functions, a persistence of executive, memory and logical reasoning deficits, and the emergence of language deficits. In patients with severe symptoms, perceptual deficits emerged and executive deficits increased, while attentional and memory deficits remained unchanged. Changes in executive functions were significantly associated with changes in depressive symptoms, but the generalised estimating equations failed to reveal any other significant effect. While most cumulative neuropsychological deficits observed at T1 persisted and even worsened over time in the subgroups of patients with moderate and severe symptoms, a significant proportion of patients, mainly in the mild subgroup, exhibited improved performances. However, we identified heterogeneous neuropsychological profiles both cross-sectionally and over time, suggesting that there may be distinct patient phenotypes. Predictors of these detrimental dynamics have yet to be identified.

Bio-efficacy of certain new insecticides against pod borer complex in pigeonpea (Cajanus cajan L.)

A study on evaluation of certain new insecticides against pod borer complex in pigeonpea was conducted at Regional Agricultural Research Station, Warangal for three consecutive years from Kharif 2019-20 to Kharif 2021 22 in medium maturity pigeonpea cultivar ‘Rudreswara’ (WRG-65). Seven treatments including untreated control were evaluated for their relative efficacy towards suppression of pod borer larval population and reduction of percent pod damage. The insecticide treatments along with untreated control were applied two times during the crop season viz., 50% flowering and pod formation stage. The results revealed that chlorantraniliprole 18.5 SC @ 0.3 ml/L followed by emamectin benzoate 5 SG proved significantly superior against gram pod borer (Helicoverpa armigera) and spotted pod borer (Maruca vitrata) with highest mean percent larval reduction and cumulative least percent pod damage (10.8 and 14.7%, respectively) over control. Further, chlorantraniliprole 18.5 SC followed by emamectin benzoate 5 SG @ 0.4 g/l recorded higher grain yields and best ICBR ratio (1:4.6; 1:4.5). Thus, the effective chemicals observed in the study could be used as basis for selection of label recommended insecticides for successful management of pod borers in pigeonpea.

Revisiting the effectiveness of biodiversity offsets in coastal wetlands of China through landscape connectivity

We modified the landscape connectivity calculation method and applied it to assess changes in temporal connectivity under different offsetting scenarios in the Yellow River Delta High-efficiency Ecological Economic Zone of China. We evaluated landscape connectivity based on resistance surfaces, least-cost distances, habitat areas, and the probability of dispersal between wetland patches in the landscape. The landscape connectivity declined between 1980 and 2015, with the degree of decline varying with the type of wetland. The cumulative percentages of freshwater marsh, salt marsh, and tidal marsh habitat areas that could be offset were 100 %, 100 %, and 34 %, respectively. However, the maximum landscape connectivity that was compensated for was only 1.2–10.4 %. When the offset patches were restored to freshwater marsh, the highest connectivity of coastal wetlands was achieved. There were substantial gaps between the area of habitat restoration offset required to achieve no net loss and the landscape connectivity that would ensure ecological effectiveness. The compensation area required to achieve no net loss of landscape connectivity was greater than that required to achieve no net loss of habitat area. We provide guidance for policy makers on how to implement offsetting to develop and manage green corridors, thus allowing movement that will ensure species’ survival. It was suggested that the passive restoration of isolated coastal wetland may be difficult to achieve. Policies that seek to increase landscape connectivity offsets can effectively promote population diffusion and migration, avoid habitat fragmentation, and are key to improving no net loss effectiveness.

Fault Diagnosis and Detection for Battery System in Real-World Electric Vehicles Based on Long-Term Feature Outlier Analysis

Accurate detection and diagnosis battery faults are increasingly important to guarantee safety and reliability of battery systems. Developed methods for battery early fault diagnosis concentrate on short-term data to analyze the deviation of external features without considering the long-term latent period of faults. This work proposes a novel data-driven method to detect long-term latent fault and abnormality for electric vehicles based on real-world operation data. Specifically, the battery fault features are extracted from the incremental capacity curves, which are smoothed by advanced filter algorithms. Secondly, principal component analysis algorithm is utilized to reduce dimensionality and the cumulative percent variance is to determine the number of significant features. Based on the features, a cluster algorithm is employed to capture the battery potential failure information. Moreover, the cumulative root-mean-square-deviation is introduced to quantificationally analyze the degree of the battery failures using large-scale battery data to avoid the missing fault reports using short-term data. In addition, a battery system failure index is proposed to evaluate battery fault conditions. The results indicate that the proposed long-term feature analysis method can effectively detect and diagnose faults.

2-YEAR GRAIN SIZE MONITORING OF THE RIVERBED SEDIMENTS FROM DANUBE DELTA

The Danube Delta was studied following the Geo-Eco-Mar expeditions in the summer and autumn of 2019 and 2020, respectively, from a sedimentological, faunal and environmental quality point of view. The grain size analyses of the sediments from the bed of the Chilia, Tulcea, Sulina, St. George Branches, as well as the meanders of the Dunărea Veche and Tătaru identified two types of sediments: sediments in which the sand fraction predominates, consisting, in general, of fine sand, and the fractions silt and clay have, in most cases, very low cumulative percentages, often below 1%; clay-silty sediments (muds), consisting predominantly of silt and clay, present in areas where the water velocity has low values. The presence of gravel is also noted, but subordinate to the sandy fractions. Gravel elements are an indicator of human impact in the area. In general, sediments also contain organogenic material, consisting of shells, fragments and plant remains. The interpretation of the data resulting from the granulometric analyzes (the percentages of clay, silt, sand, gravel and textural parameters) highlighted the dynamic conditions in which these sediments specific to the deltaic environment were deposited. In general, the amount of sand varies from one season to another and from one year to another, especially near the banks, with an increase in the sand content in the autumn season. Sandy sediments illustrate a faster flow regime, are well sorted, and are generally present in the central part of the Danube Branches bed.

Identifikasi Material Yang Berpotensi Menjadi Waste Material Pada Proyek Gedung Kuliah Terpadu B Universitas Palangka Raya

Construction projects are activities calculated to obtain maximum results in the form of buildings or infrastructure within limited time, costs and resources. Waste material in construction projects can result in material waste in construction project work. Therefore, it is necessary to identify materials that have the potential to cause waste material. This research aims to identify consumable materials in architectural work and the upper structure used which has a percentage of around (20%) which has value or has an impact of around (80%) on the construction of the Integrated Lecture Building B project at Palangka Raya University, Central Borneo. In this research, materials were identified in architectural work and upper structures that have the potential to cause material waste using the Pareto method (Pareto's law). The results of this research show the identification and grouping of material types that have the greatest rupiah value (80%) compared to other types of material and are materials that have the potential to cause material waste. The results obtained were 2 materials for upper structural work and 14 materials for architectural work. Accumulatively, the weight percentage required for the 2 materials in the upper structure work in this project is 72.25% compared to other types of upper structure materials. And the cumulative weight percentage required for the 14 materials in architectural work in this project is 79.43% compared to other types of architectural materials.

Modeling citation concentration through a mixture of Leimkuhler curves

When a graphical representation of the cumulative percentage of total citations to articles, ordered from most cited to least cited, is plotted against the cumulative percentage of articles, we obtain a Leimkuhler curve. In this study, we noticed that standard Leimkuhler functions may not be sufficient to provide accurate fits to various empirical informetrics data. Therefore, we introduce a new approach to Leimkuhler curves by fitting a known probability density function to the initial Leimkuhler curve, taking into account the presence of a heterogeneity factor. As a significant contribution to the existing literature, we introduce a pair of mixture distributions (called PG and PIG) to bibliometrics. In addition, we present closed-form expressions for Leimkuhler curves. Some measures of citation concentration are examined empirically for the basic models (based on the Power and Pareto distributions) and the mixed models derived from these. An application to two sources of informetric data was conducted to see how the mixing models outperform the standard basic models. The different models were fitted using non-linear least squares estimation.

Fabrication and Evaluation of Luliconazole contains Cationic Guar Gum intended to use for Topical application

The novel imidazole topical drug luliconazole (LCZ) has potent antifungal efficacy against a wide variety of fungi. When applied to the skin, LCZ has tremendous promise as an antifungal agent, however, constrained by its poor skin permeability and limited solubility, requiring protracted therapy and repeated dosage to achieve full recovery. The current work explains the formulation and characterization of a cationic gel prepared by using Guar Gum (GG) and pH was adjusted by using NaOH solution. The created formulation was white in color. The FTIR spectroscopy analysis shows that the medication and polymer did not react with one another. The cumulative percentage drug release suggested that LCZ was released from the formulations. All the release kinetics show that drug release from the formulation was in Fickian transport nature. The correlation value was found to be more than 0.90 in all the fitted release models. The pH of each formulation fell within the predetermined range.The prepared LCZ gel shows a viscosity between 13000 to 28000 cps, which is a very good topical application.

Abundance of Vibrio aestuarianus, water temperature, and stocking density are associated with summer mortality of Pacific oysters in suspended culture

High mortality rates of cultured Pacific oysters (Crassostrea gigas) during the summer months have regularly occurred on oyster farms in British Columbia, Canada over the last 10 years, but little is known about the microbial and environmental conditions that contribute to such mortality events. The objective of the study was to determine correlative factors associated with the onset of a summer mortality event in oysters (mean ± SD shell height: 14.2 ± 0.5 mm) grown in suspended culture at four stocking densities (150, 300, 450, 600 oysters tray−1) from May 11 to September 17, 2018. Variables examined included both biotic (oyster growth, mortality, reproductive development, and microbiome (approximately every week); Vibrio and harmful algal species abundance) and abiotic (temperature, salinity, turbidity, dissolved oxygen, pCO2, pH, and aragonite saturation) ones. Both the absolute abundance of V. aestuarianus and the relative abundance of Vibrio spp. increased with observed oyster mortality and declining health. Mortality was highest on August 12 and associated with a prior period of elevated temperatures (i.e., increasing temperatures from early July to early August) and increased oyster growth/reproductive development. At that time, systemic mixed microbial infections and necrotic gill tissue in histological cross sections were observed in 19% of oysters that appeared healthy macroscopically. Cumulative percent mortalities per tray ranged from 34 to 75%, the highest-density trays having significantly less mortality and smaller shell width, shell length, and gonad length than lower-density trays. This study demonstrates the significant impact of summer mortality on Pacific oysters and highlights the biotic (host growth, reproductive development, and microbiome composition as well as Vibrio spp. abundance) and abiotic (water temperature) factors associated with the observed mortality in this region.