Two bibliographic management products are compared in this article, RefWorks 2.0, produced by ProQuest LLC and EndNote v.X5, produced by Thomson Reuters. For the purposes of the product comparison the EndNote, a stand-alone client was loaded on an individual computer and the RefWorks Web-based, institutional version was used. Both applications were tested on the Microsoft XP Operating System using the Internet Explorer Web browser. The databases used for searching are the free PubMed database and the subscription-based Cumulative Index for Nursing and Allied Health Literature (CINAHL) database. The features of the two applications selected for comparison were based on an assumption that professional perioperative nurses will be using the software to remain current in their field. Neither features used to generate bibliographies for publication nor inserting footnotes into papers will be assessed. Several other no-cost bibliographic management software applications exist including Zotero, Mendeley, BibTex, and citulike. These applications will not be reviewed in this article. Ovadia provides nformation regarding the aforementioned no-cost bibliographic management prodcts and their respective features.