You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging/Surveillance I (MP50)1 Apr 2020MP50-10 LONG-TERM RISK OF RECURRENCE IN SURGICALLY TREATED RENAL CELL CARCINOMA: A POST-HOC ANALYSIS OF THE EASTERN COOPERATIVE ONCOLOGY GROUP - AMERICAN COLLEGE OF RADIOLOGY IMAGING NETWORK (ECOG-ACRIN) E2805 TRIAL COHORT Marcus Jamil*, Jacob Keeley, Akshay Sood, Deepansh Dalela, Sohrab Arora, James Peabody, Quoc-Dien Trinh, Mani Menon, Craig Rogers, and Firas Abdollah Marcus Jamil*Marcus Jamil* More articles by this author , Jacob KeeleyJacob Keeley More articles by this author , Akshay SoodAkshay Sood More articles by this author , Deepansh DalelaDeepansh Dalela More articles by this author , Sohrab AroraSohrab Arora More articles by this author , James PeabodyJames Peabody More articles by this author , Quoc-Dien TrinhQuoc-Dien Trinh More articles by this author , Mani MenonMani Menon More articles by this author , Craig RogersCraig Rogers More articles by this author , and Firas AbdollahFiras Abdollah More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000912.010AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Optimal post-operative surveillance for surgically resected renal cell carcinoma (RCC) remain unclear. Our primary objective was to revisit the recurrence rates of surgically treated RCC using randomized clinical trial data to determine recurrence rates. Secondary objective aimed to assess the long-term durability in clinical and pathological features in predicting disease recurrence at 0 and 60-months. METHODS: A post-hoc analysis of patients in the ECOG-ACRIN E2805 Trial was performed. Primary objective was assessed using 36-month cumulative incidence of recurrence at set intervals following surgery. Secondary objective was assessed by preforming multivariable competing risks analysis between all available covariables in the entire cohort at entry and in patients who did not have recurrence at 60-months from surgery. RESULTS: Total of 1943 patients, all with intermediate- or high-risk disease, of which 730 developed recurrence. Median follow-up 67.9 months. 36-month cumulative incidence of recurrence was found to be 31.1%, 26.0%, 18.8%, 16.1%, 18.9% and 20.3 for patients who did not have recurrence at 0, 12-, 24-, 36-, 48- and 60-months from surgery, respectively (Figure 1). At 0-months from surgery; age (hazard ratio (HR): 1.01, 95% confidence interval [CI]: 0.99 – 1.03), pathologic T3/4 stage (HR: 1.74 95%CI: 1.3 - 2.31), pathologic N1/2 stage (HR: 2.38, 95%CI: 1.85 - 3.07), Fuhrman grade 3 (HR: 1.36, 95%CI: 1.14 - 1.62), and Fuhrman grade 4 (HR: 2.36, 95%CI: 1.92 - 2.9) were independent predictors of disease recurrence. Conversely, none of the aforementioned covariables were predictors of recurrence at 60-months following surgery (Table 1). CONCLUSIONS: These findings support surveillance imaging be performed beyond 5-years following surgical resection of intermediate- to high-risk RCC. Also the usual predictors of recurrence early in the surveillance period lose their predictive capacity at 5-years. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e756-e757 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Marcus Jamil* More articles by this author Jacob Keeley More articles by this author Akshay Sood More articles by this author Deepansh Dalela More articles by this author Sohrab Arora More articles by this author James Peabody More articles by this author Quoc-Dien Trinh More articles by this author Mani Menon More articles by this author Craig Rogers More articles by this author Firas Abdollah More articles by this author Expand All Advertisement PDF downloadLoading ...