An integration of seismicity parameters, gravitational data, focal mechanisms, other geophysical data and geological information is used to determine boundaries of the Panama Block (PB) and tectonic regimes which control them. The Panama Fracture Zone represents a clear boundary between the Nazca and Cocos plate and is undergoing subduction beneath the PB. Its interaction with the Cocos Ridge at the western boundary of the block from the Panamanian shelf break and inland adds a higher degree of tectonic complexity to this area. In the north, the boundary with the Caribbean plate lies on the Panama Deformed Belt along the Caribbean margin of the Isthmus of Panama. The eastern boundary of the PB is the Panama-South America Suture Zone, in which the shear motion between the PB and the Nazca plate is coupled with major compressive forces associated with the convergence of the Nazca and South American plates. The southern boundary consists of a combination of a left-lateral transform fault, south of the Gulf of Panama, and a broad left-lateral shear zone between the Coiba Ridge and the Azuero Peninsula. The values of the Cumulative Seismic Hazard Index are greater in zones with more complex tectonics.