Cumulative Frequency Research Articles

Distribution characteristics and the evolution law of excavation damage zone in the large-span transition section of high-speed railway tunnel based on microseismic monitoring

PurposeThe microseismic monitoring technique has great advantages on identifying the location, extent and the mechanism of damage process occurring in rock mass. This study aims to analyze distribution characteristics and the evolution law of excavation damage zone of surrounding rock based on microseismic monitoring data.Design/methodology/approachIn situ test using microseismic monitoring technique is carried out in the large-span transition tunnel of Badaling Great Wall Station of Beijing-Zhangjiakou high-speed railway. An intelligent microseismic monitoring system is built with symmetry monitoring point layout both on the mountain surface and inside the tunnel to achieve three-dimensional and all-round monitoring results.FindingsMicroseismic events can be divided into high density area, medium density area and low density area according to the density distribution of microseismic events. The positions where the cumulative distribution frequencies of microseismic events are 60 and 80% are identified as the boundaries between high and medium density areas and between medium and low density areas, respectively. The high density area of microseismic events is regarded as the high excavation damage zone of surrounding rock, which is affected by the grade of surrounding rock and the span of tunnel. The prediction formulas for the depth of high excavation damage zone of surrounding rock at different tunnel positions are given considering these two parameters. The scale of the average moment magnitude parameters of microseismic events is adopted to describe the damage degree of surrounding rock. The strong positive correlation and multistage characteristics between the depth of excavation damage zone and deformation of surrounding rock are revealed. Based on the depth of high excavation damage zone of surrounding rock, the prestressed anchor cable (rod) is designed, and the safety of anchor cable (rod) design parameters is verified by the deformation results of surrounding rock.Originality/valueThe research provides a new method to predict the surrounding rock damage zone of large-span tunnel and also provides a reference basis for design parameters of prestressed anchor cable (rod).

Imaging features for the prediction of clinical endpoints in chronic liver disease: a scoping review protocol

IntroductionChronic liver disease is a growing cause of morbidity and mortality in the UK. Acute presentation with advanced disease is common and prioritisation of resources to those at highest risk...

Effects of Different 0.2% Ropivacaine Infusion Regimens for Continuous Interscalene Brachial Plexus Block on Postoperative Analgesia and Respiratory Function After Shoulder Arthroscopic Surgery: A Randomized Clinical Trial.

ObjectiveContinuous interscalene brachial plexus block (cIBPB) is an effective perioperative analgesic therapy for shoulder arthroscopic surgery (SAS) patients. This trial aimed to compare the effect of different cIBPB infusion methods on postoperative analgesia and respiratory function in patients undergoing SAS.MethodsAfter SAS, 88 patients were randomly assigned to four groups. Through interscalene catheter, all the patients received an initial dose of 10 mL 0.2% ropivacaine. The CI group received 0.2% ropivacaine 4 mL/h, and the PIBI1, PIBI2, and PIBI3 groups received intermittent 0.2% ropivacaine boluses at 4 mL/h, 8 mL/2 h, and 12 mL/3 h, respectively. The patients could also use a patient-controlled analgesia (PCA) pump to self-inject a tramadol bolus each time he/she felt pain. The primary outcome was the cumulative tramadol consumption over the 48 h after surgery. Secondary outcome measures included PCA frequency, pain (visual analogue scale, VAS) score, patient satisfaction, diaphragmatic excursion, pulmonary function, and adverse events.ResultsThe cumulative tramadol consumption and PCA frequency over the 48 h after surgery in groups PIBI2 and PIBI3 were lower than in both the CI and PIBI1 groups (p<0.001). The VAS scores (at rest and on movement) in groups PIBI2 and PIBI3 were lower than those in the CI and PIBI1 groups at 8 and 12 h after surgery (all p<0.001). Patient satisfaction scores were significantly higher in the PIBI2 group than in the other three groups (all p<0.001). Diaphragmatic excursion was significantly decreased in the PIBI3 group compared to the other three groups (p<0.05). The incidence of adverse events over the 48 h after surgery was significantly higher in the PIBI3 group compared to the other three groups (p<0.001).ConclusionProgrammed intermittent bolus infusion with 0.2% ropivacaine 8 mL/2 h for cIBPB can achieve lower tramadol consumption, along with better analgesia after surgery, lower reduction in diaphragmatic excursion, lower incidence of adverse events, and higher patient satisfaction.

Wavefield Reconstruction Inversion Based on the Multi-Scale Cumulative Frequency Strategy for Ground-Penetrating Radar Data: Application to Urban Underground Pipeline

High-precision detection of the underground pipelines is an indispensable part of the development and construction of cities. At present, the inversion technology for ground-penetrating radar (GPR) data is an effective means of realizing shallow-underground-space visualization in the field of geophysical exploration. However, the traditional full-waveform inversion (FWI) method usually faces the problems of strong nonlinearity of the objective function, high dependence on the initial model, and huge calculation cost. For improving the accuracy and efficiency of GPR data inversion, a wavefield reconstruction inversion (WRI) strategy is used for GPR data imaging to reduce the nonlinearity of the inversion problem and the dependence on the initial model. Then, the frequency weighting strategy and the multi-scale method are adopted to avoid the high-frequency component data dominating the optimization process and enhance the stability of inversion. In this paper, two numerical experiments of pipeline models with different materials and spacing or buried depths verified that the proposed method can effectively reconstruct the subsurface pipelines, and further performance of our algorithm on the field data verified the reliability of high-precision imaging of urban underground pipelines, which shows great potential of application in the field of high-precision detection of the urban underground pipelines.

Size distribution evolution and viscosity effect on spherical submicrometer particle generation process by pulsed laser melting in liquid

Spherical submicrometer particles (SMPs) can be fabricated by pulsed laser melting in liquid (PLML). In this process, raw nanoparticles dispersed in liquid are irradiated by a pulsed laser, heated over the melting point to generate molten droplets, and quenched to form SMPs. The particle size increment is caused by aggregating and merging raw particles in liquid by transient heating. In this study, the viscosity effect on the formation process of SMPs by PLML process is studied by changing aqueous glycerin solution concentration. In highly viscous liquid, smaller SMPs are generated due to the ineffective aggregation process. The temporal evolution of cumulative volume frequency of particles can be simulated, considering the constraints of the non-melting at larger size due to high heat capacity and evaporation for smaller particles by overheating. The SMP size can be controlled by viscosity of the liquid, prior disaggregation time, and liquid temperature.

Liquefaction resistance evaluation of soils using artificial neural network for Dhaka City, Bangladesh

Soil liquefaction resistance evaluation is an important site investigation for seismically active areas. To minimize the loss of life and property, liquefaction hazard analysis is a prerequisite for seismic risk management. Liquefaction potential index (LPI) is widely used to determine the severity of liquefaction quantitatively and spatially. LPI is estimated from the factor of safety of liquefaction that is the ratio of cyclic resistance ratio (CRR) to cyclic stress ratio calculated applying simplified procedure. Artificial neural network (ANN) algorithm has been used in the present study to predict CRR directly from the normalized standard penetration test blow count (SPT-N) and near-surface shear wave velocity (Vs) data of Dhaka City. It is observed that ANN models have generated accurate CRR data. Three liquefaction hazard zones are identified in Dhaka City on the basis of the cumulative frequency (CF) distribution of the LPI of each geological unit. The liquefaction hazard maps have been prepared for the city using the liquefaction potential index (LPI) and its cumulative frequency (CF) distribution of each liquefaction hazard zone. The CF distribution of the SPT-N based LPI indicates that 15%, 53%, and 69% of areas, whereas the CF distribution of the Vs based LPI indicates that 11%, 48%, and 62% of areas of Zone 1, 2, and 3, respectively, show surface manifestation of liquefaction for an earthquake of moment magnitude, Mw 7.5 with a peak horizontal ground acceleration of 0.15 g.

Ecological Risk Assessment of Trace Metal in Pacific Sector of Arctic Ocean and Bering Strait Surface Sediments.

The arctic region is a remote area with relatively few anthropogenic inputs, but there is increasing concern over toxic trace metal contamination in the Arctic Ocean. In this study, distribution characteristics of eight trace metals in the surface sediment of the Pacific Sector of the Arctic Ocean and Bering Strait are analyzed. The geochemical baseline value of each metal element is explored using the relative cumulative frequency curve method; the enrichment factor (EF), geo-accumulation index (Igeo) and potential ecological risk index (RI) are applied to assess the ecological risk level of the trace metals. According to the results, Cu, As and Hg had a little more content variation, and their contents in some areas were significantly higher than the previous reports. EF values show an obvious enrichment of element As, followed by Cr element with the moderate enrichment; the enrichment of the other six elements are not related to human activity. The Igeo value shows a moderately contaminated to heavily contaminated level of As and a moderately contaminated level of Cr. According to the potential ecological risk indexes in each site, most sites are at a low ecological risk level except five sites with RI/baseline values exceeding 150 which are at a moderate ecological risk level.

Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index.

Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous studies reported that the Arg95Ter nonsense variant of GPR151, an orphan G protein-coupled receptor, is associated with reduced BMI and reduced risk of Type 2 Diabetes (T2D). Here, we further investigate GPR151 with the Pakistan Genome Resource (PGR), which is one of the largest exome biobanks of human homozygous loss-of-function carriers (knockouts) in the world. Among PGR participants, we identify eleven GPR151 putative loss-of-function (plof) variants, three of which are present at homozygosity (Arg95Ter, Tyr99Ter, and Phe175LeufsTer7), with a cumulative allele frequency of 2.2%. We confirm these alleles in vitro as loss-of-function. We test if GPR151 plof is associated with BMI, T2D, or other metabolic traits and find that GPR151 deficiency in complete human knockouts is not associated with clinically significant differences in these traits. Relative to Gpr151+/+ mice, Gpr151-/- animals exhibit no difference in body weight on normal chow and higher body weight on a high-fat diet. Together, our findings indicate that GPR151 antagonism is not a compelling therapeutic approach to treatment of obesity.

Clinical and molecular analysis of four unrelated Chinese families with pathogenic KLHL40 variants causing nemaline myopathy 8

BackgroundHomozygous or compound heterozygous variants in the KLHL40 gene cause nemaline myopathy 8 (NEM8), a severe autosomal recessive muscle disorder characterized by prenatal polyhydramnios, fetal akinesia or hypokinesia, joint contractures, fractures, respiratory failure and dysphagia. Currently, 46 individuals with NEM8 have been described in the literature, and 30 variants in KLHL40 have been identified.ResultsHere, we reported five individuals from four unrelated Chinese families who presented common features of nemaline myopathy and infrequent clinical characteristics. Whole-exome sequencing (WES) was used to identify the causative gene. WES identified a recurrent missense variant c.1516A>C (p.Thr506Pro) and a novel frameshift variant c.543del (p.Ser182Profs*17) in KLHL40 in patient 1, a nonsense variant c.602G>A (p.Trp201*) and a missense variant c.1516A>C (p.Thr506Pro) in KLHL40 in patient 2, and homozygous variant c.1516A>C (p.Thr506Pro) in KLHL40 in patient 3 and both siblings (patients 4 and 5), all of which were confirmed by Sanger sequencing. Next, we estimated the incidence of this disorder in the southern and northern Chinese population to be 4.59/106 and 2.95/106, respectively, based on the cumulative allele frequency of pathogenic variants in internal database.ConclusionThe results of our study expand the mutation spectrum of KLHL40 and enrich our understanding of the clinical characteristics of NEM8. Genetic counseling was provided for the four families involved in this study. Given the severity and the relatively high incidence of this condition, we strongly suggest that KLHL40 be incorporated into a carrier screening panel for the Chinese population.

Driving Behavior and Decision Mechanisms in Emergency Conditions

In this article we used simulator experiments to explore the intelligent mechanisms of human decision-making. Three types of typical emergency scenarios were used in the experiment, in which Scenario 1 was used to analyze the driver’s choice to protect themselves or to protect pedestrians in emergency situations. Scenario 2 was compared with Scenario 1 to verify whether the driver’s avoidance behavior to protect pedestrians was instinctive or selective. Scenario 3 was to verify whether the driver would follow the principle of damage minimization. The driver’s decisions and actions in emergency situations, from the cumulative frequency of time to collision (TTC) to the maximum steering wheel angle rate during the experiments, were recorded. The results show that the driver was not just instinctively avoiding the immediate obstacle, but more selectively protecting pedestrians. At the same time, the time taken up by the driver’s instinctive avoidance response also had a negative impact on decision-making. The actual decisions of the driver were analyzed to provide a basis for building up the ethical decision-making of autonomous vehicles.

Identifying training needs in inland fisheries management for the fishers in the state of Bihar, eastern India

The training needs of 450 fish farmers/ fishermen from 15 randomly selected districts of Bihar (30 trainees from each district) who received training from ICAR-Central Inland Fisheries Research Institute (ICAR-CIFRI), Barrackpore, India were analysed in this study. For training need assessment (TNA), a close ended interview schedule with twenty topics was developed by ICAR-CIFRI keeping in mind the type of fisheries and water resources existing in Bihar. The trainees were asked to respond in a three point continuum scale based on the importance of the topic to them. Composite fish culture ranked highest followed by fish disease control, fish feed preparation and soil and water chemistry. Prawn culture and induced breeding of Magur were perceived as least required topics by the trainees. Cumulative cube root frequency (CCRF) method was used to classify farmers based on training needs and it was found that majority (49%) of the respondents were having medium level of training needs (0.43-0.66). Trainees with higher level of education had significant interest to know about the Government schemes related to fisheries. Trainees with non-farm related enterprises as primary/secondary occupations were highly inclined towards learning economic evaluation and hatchery management, whereas trainees with farm related enterprises as primary/secondary occupations were interested in integrated fish farming. It was also found that the fishers of different districts had varied training needs but overall ‘high training need’ was observed in composite fish culture and pond construction. Trainees’ expectations from the trainings were improvement in income, reduction in migration and debt clearance. Hence it could be inferred that need based skill development programmes are essential to ensure success of any human resource development (HRD) programme.Keywords: Bihar, Fishers, Inland fisheries management, Socio-economic background, Training need assessment

On recurrent-event win ratio.

The win ratio approach proposed by Pocock et al. (2012) has become a popular tool for analyzing composite endpoints of death and non-fatal events like hospitalization. Its standard version, however, draws on the non-fatal event only through the first occurrence. For statistical efficiency and clinical interpretability, we construct and compare different win ratio variants that make fuller use of recurrent events. We pay special attention to a variant called last-event-assisted win ratio, which compares two patients on the cumulative frequency of the non-fatal event, with ties broken by the time of its latest episode. It is shown that last-event-assisted win ratio uses more data than the standard win ratio does but reduces to the latter when the non-fatal event occurs at most once. We further prove that last-event-assisted win ratio rejects the null hypothesis with large probability if the treatment stochastically delays all events. Simulations under realistic settings show that the last-event-assisted win ratio test consistently enjoys higher power than the standard win ratio and other competitors. Analysis of a real cardiovascular trial provides further evidence for the practical advantages of the last-event-assisted win ratio. Finally, we discuss future work to develop meaningful effect size estimands based on the extended rules of comparison. The R-code for the proposed methods is included in the package WR openly available on the Comprehensive R Archive Network.

Another perspective towards energy consumption factors in Pakistan: Fresh policy insights from novel methodological framework

Lately, Pakistan's forecast for electricity consumption has shown an increasing tendency relative to its generating capability, which is concerning for the country's economic and social stability. Therefore, identifying electricity consumption factors may provide a promising mechanism to establish Pakistan's long-term sustainable policy framework. This study intends to gain a better understanding of the factors that influence electricity consumption, specifically electricity prices, economic expansion, industrialization, and urbanization. The study employs novel econometric techniques include; Lee and Strazicich [1] second generation unit root test, dynamic Autoregressive Distributed Lag Simulations (ARDLS) and the Cumulative Fourier Frequency Domain Causality (CFFDC) approach on a large dataset from 1960 to 2019. The findings reveal that energy prices and industrialization have a positive and significant long and short-run influence on energy consumption, whereas economic expansion has a favorable short-term impact on energy consumption. Suggest that energy prices, economic expansion, and industrialization can facilitate Pakistan to overcome its electricity consumption challenges. In addition, the FDC confirmed the links among the variables in the long-medium and short-run. The findings enable the policy-makers to formulate economic policy measures that would compel Pakistan to cope with the problems noted by its reliance on imported fossil fuels during a period of immense economic expansion, rapid urbanization, and use of its natural potential. Further policy suggestions are discussed in detail in the study.

Favorable Impact on Postoperative Abdominal Symptoms in Robot-assisted Radical Prostatectomy Using Enhanced Recovery After Surgery Protocol.

This study aimed to examine the effectiveness of enhanced recovery after surgery (ERAS) protocols in robot-assisted radical prostatectomy (RARP). Moreover, this study focused on postoperative abdominal symptoms and compared the perioperative parameters between the ERAS and conventional groups in RARP patients. A retrospective analysis was performed on 37 consecutive prostate cancer patients who underwent RARP between January 2020 and September 2021. The ERAS and conventional protocols were received by 16 and 20 patients, respectively, excluding one patient with surgical complications. The incidence and cumulative frequency of postoperative abdominal distention were significantly lower in the ERAS group (p=0.041 and p=0.039, respectively). Although not significant, the first flatus and defecation time tended to be shorter in the ERAS group (p=0.115 and p=0.074, respectively). The ERAS protocol contributes to the reduction in postoperative abdominal distension for patients undergoing RARP.

RETRACTED: Maternal blood concentration of tadalafil in pregnancy: Comparison of pregnant and non-pregnant women

In this study, the drug kinetics of tadalafil were compared between pregnant and non-pregnant women to determine the ideal dosage to promote uterine blood flow. We recruited five pregnant and five non-pregnant women, all of which were administered tadalafil (20mg/day). The blood concentration of tadalafil was measured 1, 2, 4, 6, 8, and 24h after administration. We investigated the side effects within 4 days of tadalafil administration and compared the cumulative frequency between the two groups. The mean area under the concentration-time curve and maximum blood concentration of tadalafil were not different between the pregnant and non-pregnant groups. Time to maximum blood concentration was delayed by 1min on average in the pregnant group compared with the non-pregnant group. The cumulative frequency of side effects was significantly lower in the pregnant group than in the non-pregnant group (P=0.026). No side effects were observed in either group after the fifth day of the tadalafil administration. Although there was no difference in maximum blood concentration between non-pregnant and pregnant women, the rate of side effects was lower in pregnant women than in non-pregnant women. Therefore, pregnant women may tolerate tadalafil better.

Orientale Ejecta at the Apollo 14 Landing Site Implies a 200-million-year Stratigraphic Time Shift on the Moon

Abstract Detailed spectral mapping, cratering statistics, and impact basin ejecta column estimates document a new and very different stratigraphic relationship for the Apollo 14 landing site. We observe a resurfacing event in the crater size–frequency distribution in agreement with a single blanketing layer. Using the crater size–frequency distribution, we determine two relative ages (cumulative crater frequencies) that match those observed for the Imbrium and Orientale basins, respectively. The pattern and strength of resurfacing and morphological distinction by spectral features suggest the top layer to be about 10–25 m thick. We propose that this top layer at the Apollo 14 landing site is Orientale basin ejecta above Imbrium basin ejecta. Such stratigraphy reattributes the (majority of) Apollo 14 samples to Orientale rather than to Imbrium basin and implies that Orientale basin is about 3.92 Gyr old, 200 million years older than previously suggested. The youngest lunar basin thus formed at the onset, rather than amid, of recorded mare volcanism. This time shift also changes constraints on early planetary and solar system processes, such as the intensity of impact bombardment, and pleads for revision of the crater-statistics-based surface ages of other planetary bodies.

Analysis on rules of acupoint compatibility and application characteristics in acupuncture treatment of migraine based on complex network technique

To analyze the compatible rules of acupoints in the treatment of migraine with acupuncture and moxibustion based on complex network technique so as to provide a reference for composing best acupoint recipes. Clinical papers about acupuncture treatment of migraine published from January of 2010 to October of 2020 were searched from Chinese and English databases including CNKI, Wanfang, VIP and Pubmed by using keywords of acupuncture, moxibustion and migraine. According to our inclusive and exclusive criteria, the collected papers were screened out to set up a database. The SPSS Modeler 18.0 software was used to analyze the association rules of acupoints, and the Gephi 0.9.2 software was used to conduct a complex network analysis about the compatibility rules of acupoints and their application characteristics of moxibustion and needling methods in the treatment of migraine. In the end, 572 articles meeting the conclusive criteria were selected, and a total of 1 091 acupoint prescriptions for the treatment of migraine were extracted, including 230 acupoints with a total appea-rance frequency of 7 902. Those acupoints most frequently used were mainly attributed to the Gallbladder Meridian, with Fengchi (GB20) being the highest in the cumulative frequency. The association rule analysis showed that the highest supporting degree acupoints was GB20-Taiyang(EX-HN5). The highest levels of confidence were EX-HN5-Touwei(ST8), GB20-Baihui(GV20), and GB20-ST8. The analysis of complex network topology showed that a total of 17 acupoints including GB20, EX-HN5, Shuaigu(GB8), Taichong(LR3), GV20, Ashi point, etc. were the core node acupoints for acupuncture treatment of migraine. In the treatment of migraine, the acupoints selected are mainly distributed in the head region. When the specific acupoints chosen, the five Shu acupoints, Yuan (source) acupoints and the confluent acupoints of eight meridians are frequently used. In terms of composing acupoint recipes, the acupoints in the local and distant part of the body are often used in combination. These outcomes may have a certain guiding significance for clinical treatment of migraine.

Submarine landslide morphometrics and slope failure dynamics along a mixed carbonate-siliciclastic margin, north-eastern Australia

Comparatively little work has been carried out on the morphology and distribution of submarine landslides on mixed carbonate-siliciclastic margins. The morphometric analysis of 84 open slope submarine landslides on the Great Barrier Reef (GBR) margin of north-eastern Australia provides useful insights into slope failure dynamics and frequency distribution of landslides on mixed margins. Our analysis has revealed that the slope area affected by failures (12.6% of the margin) is similar to siliciclastic-dominated passive margins, although the total volume of remobilized sediment (73 km3) is comparatively small. Landslide scars lie at shallower depths to the south of the margin (mean of 576 m vs 1517 m to the north) and there is good correlation between the depth at origin and depth at termination for the GBR landslides. The cumulative frequency distribution of volume, area and total length of the GBR landslides does not fit to common distributions (e.g., power law, logarithmic or exponential) for the entire dataset. Still, the cumulative frequency distribution of landslide dimensions can be statistically explained either by a power law similar to other passive margins, or by a lognormal distribution similar to some siliciclastic margins. Morphometric characteristics, such as the volume of sediment released per unit width and the probability function of volume distribution suggest that slope failures mainly involved relatively unconsolidated sediments. We find that the disintegration by debris flows was the dominant process along the entire GBR margin and that their spreading efficiency and mobility was relatively low. Margin stratigraphy, fluid overpressure at the base of the slope, and detachment surfaces at the boundary between different lithologies that separate sedimentary cycles may have preconditioned the slope to fail. This compilation provides a robust morphometric framework that allows comparison with existing and future slope failure databases, and lays the foundation for performing numerical simulations to assess the landslide-generated tsunamigenic hazards along the GBR margin.

Characteristics of patients with low back pain treated at a primary care center in Ecuador

Low back pain is a public health problem due to its high prevalence and burden of the disease. This study aimed to determine the characteristics of patients with low back pain treated at the Centro de Salud N1 from Ibarra, between January 2017 and November 2020. Two-thousand fifty-five consultations for low back pain were included, observing an increase during the study period, except for 2020 (53.78% fewer consultations than 2019). Consultation for low back pain was more frequent in women than men (64.18% vs 35.82%; z-score 12.87, p &lt;0.05). The age in men (median 49 years, interquartile range 30.75 years) was significantly higher (p=0.003) than in women (median 46 years, interquartile range 25 years). The cumulative frequency of consultations was higher between 28-60 years, mostly (67.98%) due to unspecified low back pain. Four-point seventy-nine percent of the consultations were referred to secondary care, where most (69.77%) had a specific diagnostic coding for low back pain. Regarding subsequent consultations (220 patients), most had 2 (9.05%) and less frequent ≥3 (1.65%) yearly consultations. In conclusion, there was an increase in the frequency of consultations for low back pain, predominant in the working-age groups, with a low percentage referred to secondary care.

Genesis of As in the groundwater with extremely high salinity in the Yellow River Delta, China

High arsenic (As) groundwater has been extensively found in river delta worldwide, but understanding of the influence of high salinity on As mobilization remains limited. Therefore, this study took the Yellow River Delta as the study area and tested an alternative method–ionic ratios to explore the hydrogeochemical processes of high As groundwater. Eighty–one groundwater samples and three river water samples were collected for chemical analysis. Based on inflection points of HCO3/Cl, Na/Cl, and SO4/Cl cumulative frequency distribution and hydrogeological conditions, three hydrogeochemical zones have been determined: Weathering–Fresh Water Zone (Zone I), Evaporation–Saline Water Zone (Zone II), and Seawater Mixing–Reduction Zone (Zone III). Concentrations of As and total dissolved solids (TDS) showed an increasing trend in groundwater from Zone I to Zone III. Zone I groundwater with low As and low TDS was mainly controlled by rock weathering and strong flushing. Due to intensive evaporation and seawater mixing, the TDS concentration in the groundwater of Zone II and Zone III increased sharply (up to 145997 mg/L). The high As groundwater in Zone II and Zone III was characterized by high Fe2+ and NH4+ and low NO3− and SO4/Cl, indicating that reductive dissolution of As–bearing iron oxides is the key process for As release. In addition, the significantly positive correlation between As and Cl− (>10000 mg/L) under different pH conditions indicated that intensive salinization may contribute to As mobility. Results of cluster analysis revealed that reductive dissolution is the principal driving force for As release in coastal groundwater systems and salinization is the secondary one.