This paper investigates the vibration response of a new part-screw pile composite foundation under moving train loads via a model test method. Based on the acceleration signals of the pile and the surrounding soil, a non-linear fitting method is used to establish the relationship between the dynamic attenuation coefficient and the depth of the foundation. Next, the effect of spatial location and train speed on the pile-soil dynamic interaction is investigated by introducing the pile-soil spectral amplitude ratio [Formula: see text]. In addition, the dynamic susceptibility of the part-screw pile to damage under dynamic train loads is revealed with a wavelet packet energy distribution index E DIS. Afterwards, the cumulative deformation evolution characteristics of screw pile composite foundations under long-term train loading were revealed using the frequency domain integration method. The results of this work reveal that the faster the train runs, the larger the pile-soil spectrum amplitude ratio and the more prominent the ‘dynamic concentration effect’ of the part-screw pile. The change in cross-section of the part-screw pile results in a sudden change in the vibration energy transmitted from the top of the pile, which makes the variable section of the part-screw pile more likely to cause dynamic damage or even deformation. The cumulative deformation evolution process of soil between part-screw piles under long-term cyclic train loading can be divided into three stages: slow change period, fluctuation rising period and stable deformation period. The research results have important reference significance for the optimization design of high-speed railway part-screw pile composite foundation and the planning of railway running speed.