Introduction: Millions of workers globally experience work-related injuries, leading to fatalities, injuries, job loss, and wider societal implications. This study utilizes both the U.S. database and the General Social Survey (GSS) to delve into the factors linked to occupational injuries. Methods: In this study, 30 questions from the GSS between 2002 and 2014 were used. The sample included 5,914 workers from various sectors, distributed between both female and male, and were of 18 years and above. The analysis encompasses several dimensions: demographics, job-related characteristics, administrative factors, and health and safety measures. The study particularly focuses on assessing the prevalence of three common work-related injuries: nonfatal injuries, back pain and arm pain. Logistic regression models were constructed to gauge the effects of identified factors. Results: Significant insights emerge from the analysis. Factors such as age, gender, race, working hours, overtime work, trust in management, coworker support, and workflow smoothness were identified as having notable impacts on work-related injuries. For each model, the study quantifies these impacts through odds ratio and relative effects. For example, in the nonfatal injuries model, the relative effects of age showed that workers aged 65 years or older experience a 2.56% decrease in the frequency of nonfatal injuries compared to younger workers. Furthermore, in the back pain model, the estimated odds of having back pain in males are 0.90 lower than that in females. Moreover, in the arm pain model, workers who have sufficient time to complete their tasks have estimated odds of experiencing arm pain that are 0.85 lower than those who don’t have adequate time, etc. Conclusions: Understanding the intricate interplay of various factors influencing workers’ safety and health is vital for addressing occupational injuries. By addressing these factors, there’s potential for reducing work-related injuries, enhancing work environment, and minimizing costs. Practical Applications: Organizations can use the study’s findings for reducing work related injuries. Flexible work arrangements, tailored training programs, and ergonomic improvements might highlight factors such as age, gender, and working hours. Enhancing communication, fostering a positive work culture, and prioritizing safety and health measures could reduce risks associated with trusting management and coworker support. Cost-benefit analysis and continuous monitoring ensure these interventions’ effectiveness, reduce back and hand pain incidents, minimize cost, and create safer workplaces, thereby boosting the overall well-being of workers and organizational success.