With the outstanding universal value,the precious natural and cultural heritages are the treasures left over by our ancestors.With constant deepening in the knowledge and understanding to this value,especially the aggravated damage to the natural and cultural heritages caused by natural disasters and unsustainable economic growth,the protection and site development have become one of the hotspots attracting the worldwide attention.Scientific research is an important base for the protection,which can provide the theoretical support for protection and its sustainable development.Thus,to identify the scientific issues is of vital importance in the research.In this paper,the authors discuss some key issues relating to the natural and cultural protection,management and sustainable development systematically,which are as follows:(1) paying more attention to the discovery and protection of the national heritages while applying to be listed on the World Heritage List;(2) harmonizing the relationship between the protection and sustainable development of the sites based on the principle of dynamic conservation;(3)promoting the synthesized research of natural and cultural heritages;(4) implementing participatory strategy by bringing into full play the role of the neighboring communities in protecting sites;(5) understanding the world heritage in a broad sense which should include not only the heritages accepted by the Convention Concerning the Protection of the World Cultural and Natural Heritage but also ones such as GIAHS,nature reserve,geopark,industrial etc.;and(6) strengthening the scientific research of the protection including the theories and methodology of protection,and sustainable management approaches.