The international experience of regulating the development of startup entrepreneurship indicates that when creating effective models of interaction between state authorities (development of the legal framework, development programs, strategies), education (creation of an environment, for example, accelerators, incubators, development of a beta version based on higher education institutions, which promotes startups to enter the market) and business (funding of startups, involvement in corporations), the startup ecosystem has high indicators in world ratings. The purpose of the article is to highlight the components of the international experience of regulating the development of startups that are relevant to Ukraine. The methods applied are induction, deduction, analysis, and systematization. Regulation of the development of startups at the mega level includes international clusters, international organizations, and developed countries of the world. It has been studied that the mega level includes three directions: legal, financial, and strategic. In the international environment, the "EU Startup Nations Standard" declarations signed in 2021 and laws on startups aimed at promoting the creation and development of startups are of great importance. International organizations influencing the development of startup entrepreneurship are divided by functional type and geographical scope of activity. The positive startup climate in the USA is formed through the following factors: Silicon Valley activity, flexible state regulation of this area, entrepreneurial culture, and way of thinking. Israelʼs experience reveals the need for financing research and development works. Germany and Austria have an efficiently built system of higher education. Among the directions for improving the regulation of the development of startups in Ukraine, the following are highlighted: education – the creation of a center that will help startups to develop from the beginning of the emergence of an idea to the development of the first prototypes; security – financing of military and defense developments, ecology – support for environmental startups that have the potential to expand globally, and the local ecosystem – state-region-city-community-startup.