Australia is one of the most multicultural countries in the world. Basic knowledge in skin of colour dermatology is essential if we wish to strive for clinical excellence and improved patient outcomes for all Australians. A need for further training and education in this field has been highlighted by medical practitioners around the globe. The aim of this paper is to demonstrate how skin in patients with skin of colour is biologically, functionally and structurally different to that of patients with lightly pigmented skin. This is captured through examples from common dermatological conditions and substantiated through relevant literature and expert opinion. Bias is inherent in classifications commonly used in dermatology. Morphological differences are important to recognise in those with skin of colour, and treatment needs to be carefully and individually crafted. Unique cultural consequences of a given diagnosis must also be considered when approaching themanagement of diverse populations.