This paper examines the complex dynamics of the Indo-Myanmar border regions through an array of lenses, including historical ties, economic interdependence, political relations, security concerns, and social impacts. A recent geopolitical event, the military coup in Myanmar in 2021, and the COVID-19 pandemic's impact on the economic survival of the borderland populace have been integrated into the study in a novel way. This study employs a multi-disciplinary approach to examine the transformation of historical and cultural connections into intricate economic and social systems. These systems are influenced by the interplay of local communities and national policies, such as India's "Look East Policy" and "Act East Policy" initiatives. It critiques these policies for failing to deliver on their economic pledges and highlights security vulnerabilities. It contends that the region's complexity necessitates multidimensional interventions and argues that any resolution must be collaboratively orchestrated at both the local and international levels. It persuasively argues for a nuanced approach that respects the distinctive attributes of cultural coexistence while addressing the geopolitical exigencies that compromise the stability and livelihood of border communities.