Effects Of Cues Research Articles

The who and the where: Attention to identities and locations in groups.

While it is widely accepted that the single gaze of another person elicits shifts of attention, there is limited work on the effects of multiple gazes on attention, despite real-world social cues often occurring in groups. Further, less is known regarding the role of unequal reliability of varying social and nonsocial information on attention. We addressed these gaps by employing a variant of the gaze cueing paradigm, simultaneously presenting participants with three faces. Block-wise, we manipulated whether one face (Identity condition) or one location (Location condition) contained a gaze cue entirely predictive of target location; all other cues were uninformative. Across trials, we manipulated the number of valid cues (number of faces gazing at target). We examined whether these two types of information (Identity vs. Location) were learned at a similar rate by statistically modelling cueing effects by trial count. Preregistered analyses returned no evidence for an interaction between condition, number of valid faces, and presence of the predictive element, indicating type of information did not affect participants' ability to employ the predictive element to alter behaviour. Exploratory analyses demonstrated (i) response times (RT) decreased faster across trials for the Identity compared with Location condition, with greater decreases when the predictive element was present versus absent, (ii) RTs decreased across trials for the Location condition only when it was completed first, and (iii) social competence altered RTs across conditions and trial number. Our work demonstrates a nuanced relationship between cue utility, condition type, and social competence on group cueing.

Regulation of mitochondrial network architecture and function in mesenchymal stem cells by micropatterned surfaces

Abstract Mitochondrial network architecture, which is closely related to mitochondrial function, is mechanically sensitive and regulated by multiple stimuli. However, the effects of microtopographic cues on mitochondria remain poorly defined. Herein, polycaprolactone (PCL) surfaces were used as models to investigate how micropatterns regulate mitochondrial network architecture and function in rat adipose-derived stem cells (rASCs). It was found that large pit (LP) induced rASCs to form larger and more complex mitochondrial networks. Consistently, the expression of key genes related to mitochondrial dynamics revealed that mitochondrial fusion (MFN1 and MFN2) and midzone fission (DRP1 and MFF) were increased in rASCs on LP. In contrast, the middle pit (MP) enhanced mitochondrial biogenesis, as evidenced by the larger mitochondrial area and higher expression of PGC-1. Both LP and MP promoted ATP production in rASCs. It is likely that LP increased ATP levels through modulating mitochondrial network architecture while MP stimulated mitochondria biogenesis to do so. Our study clarified the regulation of micropatterned surfaces on mitochondria, highlighting the potential of LP and MP as a simple platform to stimulate mitochondria and the subsequent cellular function of MSCs.

The effect of third-party intervention on normative behavior of bystanders: An explanation of the social norm cueing effect

Third-party interventions play a crucial role in upholding social norms and have evolutionary implications for human societies. Nevertheless, research on the effects of third-party interventions, particularly third-party compensation, on bystanders' norm compliance remains scarce. We conducted two studies to explore how third-party interventions affect bystanders' adherence to social norms and the underlying mechanisms, focusing on the perception of social norms. Study 1 examined the effects of third-party interventions, presented as group summary information, on bystanders using the dictator game paradigm. The findings revealed that both third-party punishment and compensation positively affected bystanders' fairness, with norm perceptions serving as a mediating factor. Employing a similar paradigm to Study 1, Study 2 assessed the effect of third-party interventions conveyed through individual behavior information on bystanders. The results showed that the effect of third-party interventions on bystanders' fairness depended on how representative the interventions were perceived to be. We conclude that both third-party compensation and third-party punishment can encourage bystanders to conform to social norms by shaping their norm perceptions. The findings suggest a novel method for reinforcing social norms, potentially signaling a shift from retributive to restorative justice approaches.

Signaling cues and focused prompts for professional vision support: The interplay of instructional design and situational interest in preservice teachers’ video analysis

In teacher education, video representations of practice offer a motivating means for applying conceptual teaching knowledge toward real-world settings. With video analysis, preservice teachers can begin cultivating professional vision skills through noticing and reasoning about presented core teaching practices. However, with novices’ limited prior knowledge and experience, processing transient information from video can be challenging. Multimedia learning research suggests instructional design techniques for support, such as signaling keyword cues during video viewing, or presenting focused self-explanation prompts which target theoretical knowledge application during video analysis. This study investigates the professional vision skills of noticing and reasoning (operationalized as descriptions and interpretations of relevant noticed events) from 130 preservice teachers participating in a video-analysis training on the core practice of small-group instruction. By means of experimental comparisons, we examine the effects of signaling cues and focused self-explanation prompts on professional vision performance. Further, we explore the impact of these techniques, considering preservice teachers’ situational interest. Overall, results demonstrated that preservice teachers’ professional vision skills improved from pretest to posttest, but the instructional design techniques did not generally offer additional support. However, moderation analysis indicated that training with cues fostered professional vision skills for preservice teachers with low situational interest. This suggests that for uninterested novices, signaling cues may compensate for the generative processing boost typically associated with situational interest. Research and practice implications involve the consideration of situational interest as a powerful component of instructional design, and that keyword cueing can offer an alternative when interest is difficult to elicit.

Lifetime familiarity cue effects for autobiographical memory.

Recollecting an autobiographical memory requires a cue to initiate processes related to accessing and then elaborating on a past personal experience. Prior work has shown that the familiarity of a cue can influence the autobiographical memory retrieval process. Extending this work, we tested how familiarity accrued from cumulative lifetime exposures associated with the cue-as well as associated semantic knowledge-can affect how we access and remember autobiographical memories. In Experiment 1, we measured reaction times to access and report memories in response to cue words. In Experiment 2 we examined the details with which participants described memories in response to cue words. For both experiments, participants provided estimates of lifetime exposure and semantic knowledge for each cue. In Experiment 1, we found a cue's lifetime exposure, independent of semantic knowledge, led to quicker memory access. In Experiment 2, we found the lifetime exposure and semantic knowledge of a cue interactively affected the specificity of a described autobiographical memory. These results provide new evidence that the amount of lifetime exposure associated with a cue, both independently and interactively with semantic knowledge, influences how autobiographical memories are accessed and described.Clinical trial This was not a clinical trial.Trial Registration Number (TRN) N/A.

The Differential Effects of Multisensory Attentional Cues on Task Performance in VR Depending on the Level of Cognitive Load and Cognitive Capacity.

As the utilization of VR is expanding across diverse fields, research on devising attentional cues that could optimize users' task performance in VR has become crucial. Since the cognitive load imposed by the context and the individual's cognitive capacity are representative factors that are known to determine task performance, we aimed to examine how the effects of multisensory attentional cues on task performance are modulated by the two factors. For this purpose, we designed a new experimental paradigm in which participants engaged in dual (N-back, visual search) tasks under different levels of cognitive load while an attentional cue (visual, tactile, or visuotactile) was presented to facilitate search performance. The results showed that multi-sensory attentional cues are generally more effective than uni-sensory cues in enhancing task performance, but the benefit of multi-sensory cues changes according to the level of cognitive load and the individual's cognitive capacity; the amount of benefit increases as the cognitive load is higher and the cognitive capacity is lower. The findings of this study provide practical implications for designing attentional cues to enhance VR task performance, considering both the complexity of the VR context and users' internal characteristics.

Towards more trusted virtual physicians: the combinative effects of healthcare chatbot design cues and threat perception on health information trust

ABSTRACT Although virtual healthcare assistants have been extensively adopted in the healthcare industry, users still question their reliability. Based on the Computers are Social Actor (CASA) paradigm, the current study conducted an experiment to examine how different chatbot design cues (Chatbot vs. Layperson vs. Doctor) affect users’ trust towards virtual healthcare assistants. Results indicate that the doctor-like design cues and bot-like design cues (vs. layperson-like design cues) elicited significantly greater perceived chatbot expertise, which enhanced users’ trust in health information. This study further found the significant moderating effects of users’ perceived threat on chatbot expertise and privacy concerns. Positive effects of the doctor-like design cue and the bot-like design cue on perceived expertise were found to be significant only for those whose perceived threat was high. Interestingly, the doctor-like design cues led to greater (less) privacy concerns when the perceived threat level was low (high). The findings provide human–computer interaction researchers and chatbot UX/UI designers with important theoretical and practical implications.

Decoding the effect of photoperiodic cues in transducing kisspeptin-melatonin circuit during the pubertal onset in common carp.

This study unravels the intricate interplay between photoperiod, melatonin, and kisspeptin to orchestrate the pubertal onset of Common carp. Female fingerlings exposed to long days (LD) exhibited a hormonal crescendo, with upregulated hypothalamic-pituitary-ovarian (HPO) axis genes (kiss1, kiss1r, kiss2, gnrh2, gnrh3) and their downstream targets (lhr, fshr, ar1, esr1). However, the expression of the melatonin receptor (mtnr1a) diminished in LD, suggesting a potential inhibitory role. This hormonal symphony was further amplified by increased activity of key transcriptional regulators (gata1, gata2, cdx1, sp1, n-myc, hoxc8, plc, tac3, tacr3) and decreased expression of delayed puberty genes (mkrn1, dlk1). In contrast, short days (SD) muted this hormonal chorus, with decreased gnrh gene and regulator expression, elevated mtnr1a, and suppressed gonadal development. In in-vitro, estradiol mimicked the LD effect, boosting gnrh and regulator genes while dampening mtnr1a and melatonin-responsive genes. Conversely, melatonin acted as a conductor, downregulating gnrh and regulator genes and amplifying mtnr1a. Our findings illuminate the crucial roles of melatonin and kisspeptin as opposing forces in regulating pubertal timing. LD-induced melatonin suppression allows the kisspeptin symphony to flourish, triggering GnRH release and, ultimately, gonadal maturation. This delicate dance between photoperiod, melatonin, and kisspeptin orchestrates common carp's transition from juvenile to reproductive life.

Investigating the Effect of Contextual Cueing with Face Stimuli on Electrophysiological Measures in Younger and Older Adults.

Extracting repeated patterns from our surroundings plays a crucial role in contextualizing information, making predictions, and guiding our behavior implicitly. Previous research showed that contextual cueing enhances visual search performance in younger adults. In this study, we investigated whether contextual cueing could also improve older adults' performance and whether age-related differences in the neural processes underlying implicit contextual learning could be detected. Twenty-four younger and 25 older participants performed a visual search task with contextual cueing. Contextual information was generated using repeated face configurations alongside random new configurations. We measured RT difference between new and repeated configurations; ERPs to uncover the neural processes underlying contextual cueing for early (N2pc), intermediate (P3b), and late (r-LRP) processes; and multiscale entropy and spectral power density analyses to examine neural dynamics. Both younger and older adults showed similar contextual cueing benefits in their visual search efficiency at the behavioral level. In addition, they showed similar patterns regarding contextual information processing: Repeated face configurations evoked decreased finer timescale entropy (1-20 msec) and higher frequency band power (13-30 Hz) compared with new configurations. However, we detected age-related differences in ERPs: Younger, but not older adults, had larger N2pc and P3b components for repeated compared with new configurations. These results suggest that contextual cueing remains intact with aging. Although attention- and target-evaluation-related ERPs differed between the age groups, the neural dynamics of contextual learning were preserved with aging, as both age groups increasingly utilized more globally grouped representations for repeated face configurations during the learning process.

Effects of sleep deprivation on food-related Pavlovian-instrumental transfer: a randomized crossover experiment.

Recent research suggests that insufficient sleep elevates the risk of obesity. Although the mechanisms underlying the relationship between insufficient sleep and obesity are not fully understood, preliminary evidence suggests that insufficient sleep may intensify habitual control of behavior, leading to greater cue-elicited food-seeking behavior that is insensitive to satiation. The present study tested this hypothesis using a within-individual, randomized, crossover experiment. Ninety-six adults underwent a one-night normal sleep duration (NSD) condition and a one-night total sleep deprivation (TSD) condition. They also completed the Pavlovian-instrumental transfer paradigm in which their instrumental responses for food in the presence and absence of conditioned cues were recorded. The sleep × cue × satiation interaction was significant, indicating that the enhancing effect of conditioned cues on food-seeking responses significantly differed across sleep × satiation conditions. However, this effect was observed in NSD but not TSD, and it disappeared after satiation. This finding contradicted the hypothesis but aligned with previous literature on the effect of sleep disruption on appetitive conditioning in animals-sleep disruption following learning impaired the expression of appetitive behavior. The present finding is the first evidence for the role of sleep in Pavlovian-instrumental transfer effects. Future research is needed to further disentangle how sleep influences motivational mechanisms underlying eating.

Preparation and persistence of deploying attention to locations or stimulus structures: Evidence from intermixed probe trials

Attention can be directed to the global or local level of a visual stimulus (i.e., Navon figure). Previous studies yielded reliable trial-to-trial level switch costs (i.e., worse performance when responding to the other level than on a previous trial), even though level cueing effects indicated anticipatory deployment of attention to the upcoming target level. To investigate the interplay of attentional preparation and persistence, we applied a probe trial method assumed to ensure a high degree of preparation for the upcoming target level and minimizing stimulus-specific proactive interference. Mirroring previous findings obtained in the domain of spatial attention, we found evidence for anticipatory attentional focusing on global/local target levels but not for persistence of the attentional set adopted on the previous trial. In a second experiment, we prevented preparation for upcoming attentional demands (in both global-local and spatial attention tasks). This resulted in the modulation of performance (in critical probe trials) by the attentional demands of the predecessor trial. Together, our findings demonstrate sensitivity of the probe trial method for attentional persistence and raise the possibility that such persistence can be completely eliminated by sufficiently strong preparation for the attentional demands of the following trial.

The representation of contextual cue is stimulus-specific yet its expression is flexible.

Contextual cueing refers to the phenomenon in which individuals utilize frequently encountered environmental contexts, comprised of distractors, as cues to expedite a target search. Due to the conflict between the widespread occurrence of contextual cue transfer and the observed impact of changing the identity of distractors on contextual cue learning, the content of contextual cue representations remains contentious. Considering the independent nature of contextual cue learning and expression, our proposition is twofold: (1) Contextual cue representations are stimulus-specific, and (2) their expression is highly flexible. To validate the model, two experiments were conducted. Experiment 1 aimed to confirm the hypothesis that contextual cue representations are stimulus-specific. We manipulated the identity consistency of distractors within repeated scenes during contextual cue learning. Difficulty in contextual cue learning under the identity-changing condition would suggest the necessity of identity within contextual cue representation, indicating the stimulus-specific nature of these representations. Experiment 2 was designed to affirm the conclusion of Experiment 1 and explore the flexibility in the expression of contextual cue representations. This experiment comprised two phases: learning and testing. During the learning phase, participants were exposed to two sets of repeated scenes in different colors under two learning conditions: load and no-load. Working memory load was introduced to interfere with the expression to prevent it from becoming automatic. In the subsequent testing phase, the colors of the two scene sets were interchanged to impede retrieval based on identity. If both load and no-load conditions demonstrate similar levels of contextual cue effects during the testing phase, it implies the flexibility in the expression of contextual cue representations and confirms the conclusion of Experiment 1. In Experiment 1, a notable contextual cue learning effect was observed under the identity-consistent condition (p = 0.001). However, this effect was not evident under the identity-changing condition (p = 0.286). This finding strongly supports the stimulus-specific nature of contextual cue representation. In Experiment 2, the contextual cueing effect appeared but did not show a significant difference between the two conditions (t(23) = 0.02, p = 0.987, BF10 = 0.215), indicating the cognitive system's ability to flexibly redefine retrieval cues. This adaptability aligns with our hypothesis and confirms the high flexibility in the expression process of contextual cue representations and confirms the conclusion of Experiment 1.

The Role of Stimulus Uncertainty and Curiosity in Attention Control.

Most cognitive psychological studies assume that participants in lab-based tasks maintain a single goal based on task instructions. However, people can be motivated by other factors, such as curiosity. We examined if people attend to seemingly task-irrelevant information out of curiosity by manipulating stimulus uncertainty in a cueing paradigm. Participants were presented with an abrupt-onset cue followed by a letter target (E or H). Next, a mask either at the target location (low uncertainty) or at all four locations (high uncertainty) was shown. We expected high uncertainty to induce a state of curiosity that in turn influences the processing of the cue. Cueing effects were greater in the high-uncertainty condition compared to the low-uncertainty condition. In Experiment 2, we additionally elicited self-report ratings on curiosity. In sum, target-specific uncertainty leads to greater processing of task-irrelevant peripheral cues across two experiments. We tentatively conclude that uncertainty modulates attention control and further research is necessary to examine if this is indeed due to curiosity induced by uncertainty.

Lexical and perceptual biases in speakers’ syntactic choices

ABSTRACT Russell Tomlin’s groundbreaking work laid a foundation for the explorations of the interplay between linguistic and nonlinguistic factors determining structural choice during sentence production. The present article investigates the interplay between two such factors, lexical priming and visual cueing, which may prioritize a particular referent of an event for privileged subject status within a sentence. To this end, native speakers of English read noun names of either the agent or the patient prior to describing a transitive event. Before the event description, an exogenous visual cue directed their attention to the location of one of the event’s referents. Analysis of the proportion of passive-voice descriptions revealed a strong effect of lexical priming with more passives after patient-related lexical primes but no effect of visual cueing. This highlights potential constraints on previously documented visual cueing effects on speakers’ structural choices.

Can I see myself there? How Black potential applicants use diversity cues to learn about graduate program climate.

In academia, showcasing diversity, equity, and inclusion (DEI) values has become increasingly prominent in efforts to recruit students and faculty with marginalized identities, yet little work has examined the empirical effects that such DEI practices and identity safety cues have on the perceptions of these institutions. In the present study, we examine the contextual factors that shape how Black science, technology, engineering, and mathematics (STEM) students learn and draw inferences about diversity and cultural climate in the graduate programs to which they consider applying. A sample of 217 Black participants with background in a STEM discipline viewed a mock academic department website which presented varied combinations of expressed diversity cues (diversity vs. neutral mission statement) and/or evidence-based diversity cues (racially diverse vs. all-White faculty). Participants reported perceptions of the department's DEI culture, their own perceived fit within the program, and belief of future personal success within that institution. Results indicated a significant main effect of evidence-based cue, in the form of faculty diversity, on all examined outcomes, with Black participants more positively assessing a program exhibiting this cue. An expressed cue, in the form of diversity statement, did not have significant effects. These results indicate that in higher education, as in other settings, evidence-based cues may be more effective means to cue identity safety. This study provides a foundation for future research to help guide efforts of academic programs seeking to create a welcoming and supportive climate for all potential applicants. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Variable effects of speakers’ visual cues and accent on L2 listening comprehension: A mixed-methods approach

Few studies have explored the influence of a speaker’s accent and visual (facial and gestural) cues on second-language (L2) listening comprehension. The current mixed-methods between-groups design investigated: (1) the effects of accent and visual cues on Arab students’ comprehension of recorded lectures delivered by two speakers: first language (L1) American English and second language (L2) English (strong Vietnamese accent), (2) students’ assessments of the comprehensibility and English nativelikeness of the accents, and (3) students’ perceptions of and preferences for visual cues in communication. A total of 120 Arab university students were distributed across three stimulus conditions: auditory-visual (AV)-gesture-face, AV-face, and A-only within two accent conditions (L1, L2 English). Materials included: a listening comprehension task, 9-point rating scales for comprehensibility and nativelikeness of accent, and a speaker’s accent and visual cues (SAVC) questionnaire. ANCOVAs were conducted on listening comprehension scores and the ratings, with students’ listening proficiency as the covariate. Students with higher listening proficiency received higher comprehension scores and tended to recognize the L1 English accent as nativelike; however, proficiency was not significantly related to their comprehensibility ratings of either accent. The L1 English speaker’s gestures were associated with higher comprehensibility ratings; the L2 English speaker’s gestures were associated with a stronger nonnativelike accent, which students found frustrating to comprehend. Although SAVC responses revealed a general preference for facial cues and gestures in daily communication, the L2 English speaker’s gestures in the study were not considered helpful. Thematic analysis of interviews emphasized: (1) the variable effectiveness of visual cues, (2) the important role of topic and accent familiarity, (3) the relationship between listening proficiency and interlocutor/instructor preference, and (4) strategies to deal with unfamiliar accents. Pedagogical implications include increased awareness of variability in visual cues across speakers and the need to build familiarity with various accents and gesture patterns.

Insights into adhesion and osteogenesis of bone marrow stromal cells promoted by surface nanopatterns

The surface property of biomaterials has a profound influence on the adhesion and biofunction of mesenchymal stem cells, which is vital for successful implantation and regeneration. Nanotopological surface is capable of mimicking bone's extracellular matrix (ECM) to regulate cell behavior, the understanding of which however remains elusive. In this study, we decoupled the effect of nanotopological cues from two perspectives: nanostructure and specific surface area. Bone marrow-derived mesenchymal stem cells (BMSCs) displayed stable and organized F-actin fibers, forming intricate myosin networks on the poly (ε-caprolactone) (PCL) substrate decorated with a well-defined nanopattern that was formed by the PCL lamellae. The cell spreading and myosin activation were limited when the specific surface area of the nanopattern was reduced. These findings illustrate that the specific surface area of the nanopatterned surface is a dominant regulator for cell mechanosensing. Our results highlight the potential of optimizing biomaterial interfaces to enhance cell adhesion and functionality for bone regeneration.

Development of Cell Culture Platforms for Study of Trabecular Meshwork Cells and Glaucoma Development.

Various cell culture platforms that could display native environmental cue-mimicking stimuli were developed, and effects of environmental cues on cell behaviors were studied with the cell culture platforms. Likewise, various cell culture platforms mimicking native trabecular meshwork (TM) composed of juxtacanalicular, corneoscleral and uveal meshwork located in internal scleral sulcus were used to study effects of environmental cues and/or drug treatments on TM cells and glaucoma development. Glaucoma is a disease that could cause blindness, and cause of glaucoma is not clearly identified yet. It appears that aqueous humor (AH) outflow resistance increased by damages on pathway of AH outflow can elevate intraocular pressure (IOP). These overall possibly contribute to development of glaucoma. For the study of glaucoma, static and dynamic cell culture platforms were developed. Particularly, the dynamic platforms exploiting AH outflow-mimicking perfusion or increased IOP-mimicking increased pressure were used to study how perfusion or increased pressure could affect TM cells. Overall, potential mechanisms of glaucoma development, TM structures and compositions, TM cell culture platform types and researches on TM cells and glaucoma development with the platforms were described in this review. This will be useful to improve researches on TM cells and develop enhanced therapies targeting glaucoma.

The effect of viewing visual cues in a listening comprehension test on second language learners’ test-taking process and performance: An eye-tracking study

In this study, we examined the effect of visual cues in a second language listening test on test takers’ viewing behaviours and their test performance. Fifty-seven learners of English in Korea took a video-based listening test, with their eye movements recorded, and 23 of them were interviewed individually after the test. The participants viewed the visual cues longer than the items in the multiple-choice questions. Looking at the correct answer choice was related to a higher test score, while looking at the speaker(s) in the video and the distractors of the test items to a lower test score. Viewing the PowerPoint slides showed mixed effects on test performance, depending on different eye-movement measures. Stimulated-recall interviews shed further light on the possible reasons for the different patterns of the participants’ eye movements. Overall, the participants held the positive view that the visual cues aided them in comprehending the aural input and in completing the listening tasks more successfully. We discuss these findings in relation to the authenticity of tasks and the construct relevance of video-based listening tests.

Auditory cues modulate the short timescale dynamics of STN activity during stepping in Parkinson's disease

BackgroundGait impairment has a major impact on quality of life in patients with Parkinson's disease (PD). It is believed that basal ganglia oscillatory activity at β frequencies (15–30 Hz) may contribute to gait impairment, but the precise dynamics of this oscillatory activity during gait remain unclear. Additionally, auditory cues are known to lead to improvements in gait kinematics in PD. If the neurophysiological mechanisms of this cueing effect were better understood they could be leveraged to treat gait impairments using adaptive Deep Brain Stimulation (aDBS) technologies. ObjectiveWe aimed to characterize the dynamics of subthalamic nucleus (STN) oscillatory activity during stepping movements in PD and to establish the neurophysiological mechanisms by which auditory cues modulate gait. MethodsWe studied STN local field potentials (LFPs) in eight PD patients while they performed stepping movements. Hidden Markov Models (HMMs) were used to discover transient states of spectral activity that occurred during stepping with and without auditory cues. ResultsThe occurrence of low and high β bursts was suppressed during and after auditory cues. This manifested as a decrease in their fractional occupancy and state lifetimes. Interestingly, α transients showed the opposite effect, with fractional occupancy and state lifetimes increasing during and after auditory cues. ConclusionsWe show that STN oscillatory activity in the α and β frequency bands are differentially modulated by gait-promoting oscillatory cues. These findings suggest that the enhancement of α rhythms may be an approach for ameliorating gait impairments in PD.