CuO Nanoparticles Research Articles

Sonochemical synthesis of S-scheme CuO/CeO2 heterojunction for enhanced photocatalytic degradation of rhodamine B dye under solar radiations

CeO2 is renowned photocatalyst with 2.8 eV band gap energy and exceptional optical features. However, the slow charge transportation and the fast recombination of the electron-hole pair hindered the photocatalytic efficiency. In this pioneering research, S-scheme CuO/CeO2 heterojunctions were engineered sonochemically with rational compositions of CeO2 and CuO nanoparticles for enhanced the photocatalytic efficiency of CeO2 in destructing rhodamine B dye under full solar radiations. Diffuse reflectance spectrum [DRS], photoluminescence [PL], high resolution transmission electron microscope [HRTEM], selected area electron diffraction [SAED], N2-adsorption-desorption isotherm, X-ray photoelectron spectroscopy [XPS] and X-ray diffraction [XRD] investigated the physicochemical properties of CuO/CeO2 heterojunction. Monoclinic CuO nanoparticles of 8 nm size are facilely incorporated in cubic CeO2 crystallites of 27.3 nm through substitution of Ce4+ by Cu2+ ions which ascribed to smaller ionic radii of Cu2+ compared with Ce4+ and Ce3+ ions. Homogeneous distribution of CuO nanoparticles on CeO2 surface was further investigated by SEM and TEM analysis. HRTEM, XRD, SAED and XPS analysis recorded the co-existence of crystalline peaks of CeO2 and CuO implying the successful construction of CuO/CeO2 heterojunction. The depression in the surface area of CeO2 from 91.4 to 83.6 m2/g with incorporating 5 wt % of CuO revealed the deposition of CuO on CeO2 surface. XPS analysis implied the existence of Ce3+ and oxygen vacancies that provide more adsorption sites for oxygen, which are beneficial for enhancing the catalytic performance of catalysts. CuO nanoparticles with 1.3 eV band energy enhanced the visible light absorbability of the heterojunctions in deep visible region for broading the photocatalytic response. Significant reduction in photoluminescence signals intensity by 60 % with incorporation 5 wt % of CuO revealed the favorable reduction in the rate of electron-hole recombination. In particular, CeCu5 containing 5 wt % CuO expelled 96 % of RhB dye within 6-h under solar simulator compared with 13 % removal on pristine CeO2 and CuO surface. Hot radicals and positive holes degraded RhB dye molecules on the heterojunction surface as elucidated from scavenger experiments and PL analysis of terephthalic acid. The exceptional removal of RhB dye under solar radiation was ascribed to the alignment in the band structure of CeO2 and CuO nanoparticles and the successful production of an efficient S-scheme heterojunction with strong redox potential and better electron transportation and separation.

Green and chemical synthesis of CuO nanoparticles: comparative reproductive toxicity evaluation at various phases and in offsprings

Metallic nanoparticles (NPs) are used in various biomedical applications due to their widespread utility. This study compares the reproductive toxicity of chemically synthesized CuO NPs (ChemSyn CuO NPs) and green synthesized CuO NPs (GrSyn CuO NPs) in rats and their offspring during mating, pregnancy, and lactation phases. CuO NPs were synthesized using Rhus punjabensis extract and their physio-morphological characteristics were illustrated. Both approaches showed pure and spherical NPs with an average size of 14.94 ± 0.6 and 19.02 ± 0.9 nm. Orally administered NPs at a dose of 100 mg kg−1 body weight of ChemSyn NPs reduced peroxidase activity by 38% and glutathione levels by 36%. In female rats treated with ChemSyn NPs, TBARS were increased by 11%, and total protein increased by 54%. The offspring did not show notable differences in their antioxidant status, but reactive substances in female offspring increased by 32%, and total protein content decreased by 57%. Genotoxicity of 2.72% and 1.9% tail DNA was observed in male and female pups, respectively. Testosterone levels were reduced in male parents, and progesterone concentration increased in female parents in a dose-dependent manner. In contrast, GrSyn NPs were more biocompatible, and thyroid hormones in the parents showed less variation. No obvious alterations were observed in the histological patterns of the gonads. These findings indicate that GrSyn NPs can be explored as drug carriers and contrast agents in vivo.

Biogenic Synthesis of Copper Oxide Nanoparticles from Aloe vera: Antibacterial Activity, Molecular Docking, and Photocatalytic Dye Degradation.

Green synthesis methods offer a cost-effective and environmentally friendly approach to producing nanoparticles (NPs), particularly metal-based oxides. This study explores the green synthesis of copper oxide nanoparticles using Aloe vera (Aloe barbadensis Miller) leaf extract. The characterization revealed a unique sago-shaped morphology revealed by field-emission scanning electron microscopy and X-ray diffraction analysis. Distinctive metal-oxygen bonds at 521 and 601 cm-1 were confirmed by Fourier-transform infrared (FT-IR) spectroscopy. Furthermore, UV-visible spectroscopy revealed absorbance at 248 nm, suggesting electron transitions across energy bands and varying surface conduction electrons. The band gap value indicated the presence of quantum confinement effects, which were probably caused by the distinctive morphology and surface structure of the biogenic NPs. Additionally, molecular docking studies were carried out against key proteins of Salmonella typhi and Listeria monocytogenes, namely, listeriolysin O (PDB ID: 4CDB), internalin (InlA) (PDB ID: 1O6T), Salmonella effector protein (SopB) (PDB ID: 4DID), and YfdX (PDB ID: 6A07) using AutoDock 4.2. The results revealed binding energies against S. typhi and L. monocytogenes proteins, indicating potential interactions establishing the foundation for further in-depth understanding of the molecular basis underlying the observed antibacterial effects in vitro against S. typhi, Klebsiella pneumoniae, Pseudomonas aeruginosa, and L. monocytogenes. Antibacterial activity evaluation yielded impressive results, with CuO NPs displaying significant activity against S. typhi and L. monocytogenes, exhibiting zones of inhibition values of 13 ± 0.02 and 15 ± 0.04 mm, respectively. Moreover, the CuO NPs demonstrated remarkable photocatalytic efficacy, resulting in the degradation of 77% of the methylene blue dye when exposed to UV irradiation. This study highlighted the potential of green-synthesized CuO NPs derived from A. vera with their unique morphology, interesting spectroscopic properties, and promising antibacterial and photocatalytic activities.

Adsorption‐Based Approaches for Exploring Nanoparticle Effectiveness in Wastewater Treatment

AbstractThe treatment of wastewater is essential to preserving the environment and public health. Recent advances in this field have made nanoparticles attractive tools due to their exceptional selectivity, reactivity, and surface area. Particularly, their use in adsorption‐based wastewater treatment has garnered significant interest, focusing on how well nanoparticles can adsorb chemical contaminants, thereby improving treatment effectiveness. A thorough analysis explores various aspects of nanoparticles in wastewater treatment, including different types of nanoparticles used for adsorption, underlying mechanisms, and numerous factors affecting their pollutant removal efficiency. However, it also recognizes potential negative environmental impacts, underscoring the need for comprehensive risk assessments, including eco‐toxicity, release dynamics, and long‐term ecological effects. In light of these challenges, the review emphasizes the revolutionary potential of new nanoparticles in transforming wastewater treatment paradigms. Examples include ZnO nanoparticles and Fe₃O₄ magnetic nanoparticles (MNPs), which excel at removing dyes and reducing sludge volume, while CuO and TiO₂ nanoparticles rapidly eliminate organic pollutants and heavy metals like Pb2+. Additionally, graphical illustrations highlight nanoparticles′ advantages, especially in removing cadmium. These findings underscore the future direction of research on wastewater treatment using nanoparticles, pointing toward increased sustainability and efficiency in addressing water pollution issues.

Impact of CuO nanoparticles on Dunaliella spp. BDUG10113 Growth, Photosynthesis, and Cellular Processes

Impact of CuO nanoparticles on Dunaliella spp. BDUG10113 Growth, Photosynthesis, and Cellular Processes

Band engineering for building cascading charge transport channels in ternary CdS-based nanorod array photoanode toward efficient photoelectrochemical H2 generation

A novel CdS/CdSe/Cu2O nanorod array (NRA) photoelectrode with cascading charge transport channels was designed for the first time to remarkedly boot photoelectrochemical (PEC) hydrogen generation under visible light illumination with zero bias. This ternary photoelectrode was constructed by modifying CdS nanorod arrays with n-type CdSe and p-type Cu2O nanoparticles, successively. In this novel photoanode, CdSe and Cu2O with small band gap not merely highly heighten the visible light absorption capacity of CdS, but more importantly integrate with CdS to build cascading charge transport channels at the CdS/CdSe and CdSe/Cu2O interfaces, dramatically facilitating the separation and transport efficiency for photoexcited electron and hole pairs. The CdS/CdSe/Cu2O NRA photoelectrode gains an obvious hydrogen generation rate of 193.2 μmol·h−1, 8.2 times higher than that of bare CdS NRA photoelectrode. The remarkably enhanced PEC hydrogen production for the CdS/CdSe/Cu2O NRA photoanode can be ascribed to effective solar energy utilization and charge carrier separation.

Enhancing Radiator Cooling with CuO Nanofluid Microchannels

The study explores in employing copper oxide (CuO) nanofluid as a cooling medium in the vehicle radiators. To simulate the heat transfer process, the microchannel is constructed using elec-tron discharge machining (EDM) and a computational fluid dynamics (CFD) modeling is em-ployed. UV-visible spectroscopy, scanning electron microscopy (SEM), and dynamic light scat-tering (DLS) are used to characterize the CuO nanofluid. CuO nanofluid surpasses water in the heat transfer capabilities, with a 40% improvement in thermal conductivity. The average size of CuO nanoparticles was determined via DLS to be 485.1 nm. The heat transfer coefficient of CuO nanofluid is 5366 W/m2K, which is 116% larger than that of water. The increased heat transfer capabilities of CuO nanofluid microchannel flow indicate to its potential as a viable replacement for conventional radiators in the automotive applications. Lower engine tempera-tures, increased fuel efficiency, and longer engine lifespan may result from improved cooling performance. Due of the small size of microchannels, more efficient and space-saving radiators for automobiles are conceivable. More research is needed to improve the microchannel design as well as to realize the practical benefits of CuO nanofluids in car cooling systems.

PH-Dependent Morphology of Copper (II) Oxide in Hydrothermal Process and Their Photoelectrochemical Application for Non-Enzymatic Glucose Biosensor

In this study, we investigated the influence of pH on the hydrothermal synthesis of copper (II) oxide CuO nanostructures with the aim of tuning their morphology. By varying the pH of the reaction medium, we successfully produced CuO nanostructures with three distinct morphologies including nanoparticles, nanorods, and nanosheets according to the pH levels of 4, 7, and 12, respectively. The observed variations in surface morphology are attributed to fluctuations in growth rates across different crystal facets, which are influenced by the presence of intermediate species within the reaction. This report also compared the structural and optical properties of the synthesized CuO nanostructures and explored their potential for photoelectrochemical glucose sensing. Notably, CuO nanoparticles and nanorods displayed exceptional performance with calculated limits of detection of 0.69 nM and 0.61 nM, respectively. Both of these morphologies exhibited a linear response to glucose within their corresponding concentration ranges (3–20 nM and 20–150 nM). As a result, CuO nanorods appear to be a more favorable photoelectrochemical sensing method because of the large surface area as well as the lowest solution resistance in electroimpedance analysis compared to CuO nanoparticles and nanosheets forms. These findings strongly suggest the promising application of hydrothermal-synthesized CuO nanostructures for ultrasensitive photoelectrochemical glucose biosensors.

A Green Approach: Syzygium aromaticum Mediated Synthesis of CuO Nanoparticles with Potential for Wastewater Treatment

A Green Approach: Syzygium aromaticum Mediated Synthesis of CuO Nanoparticles with Potential for Wastewater Treatment

Novel antimicrobial applications of copper oxide nanoparticles after combination with tissue conditioner used in complete prostheses

BackgroundTissue conditioners are used for treating and improving the tissues supporting complete dentures. On the other hand, recent advances in nanotechnology have revolutionized various fields of science, including dentistry. The present study aimed to investigate novel antimicrobial applications of copper oxide nanoparticle-based tissue conditioner used in complete prostheses.MethodsThe present experimental study included 126 tissue conditioner samples with different concentrations of copper oxide nanoparticles (20%, 10%, 5%, 2.5%, 1.25%, 0.625%, and 0% w/w). The samples were incubated with Enterococcus faecalis, Pseudomonas aeruginosa, and Candida albicans in 24-well plates for 24 h. Then, samples from the wells were re-incubated for 24 h, and the microorganisms were counted.ResultsThe culture media containing E. faecalis and P. aeruginosa showed significantly different growth between different nanoparticle concentrations following 24 h (P < 0.001), showing a reduction in bacterial growth with increased nanoparticle concentration. Both bacteria did not show any growth at the 20% concentration. However, C. albicans showed significant differences in growth between different nanoparticle concentrations following 48 h (P < 0.001), showing a reduction in growth with increased nanoparticle concentration. Also, the least growth was observed at the 20% concentration.ConclusionsIn conclusion, the CuO nanoparticles were prepared using a green synthesis methon in the suitable sizes. Moreover, the tissue conditioners containing CuO nanoparticles showed acceptable antimicrobial properties against E. faecalis, P. aeruginosa, and C. albicans.

CO2 Electroreduction by Engineering the Cu2O/RGO Interphase

In the present investigation, Cu2O-based composites were successfully prepared through a multistep method where cubic Cu2O nanoparticles (CU Cu2O) have been grown on Reduced Graphene Oxide (RGO) nanosheets. The structural and morphological properties of the materials have been studied through a comprehensive characterization, confirming the coexistence of crystalline Cu2O and RGO. Microscopical imaging revealed the intimate contact between the two materials, affecting the size and the distribution of Cu2O nanoparticles on the support. The features of the improved morphology strongly affected the electrochemical behavior of the composites, increasing the activity and the faradaic efficiencies towards the electrochemical CO2 reduction reaction process. CU Cu2O/RGO 2:1 composite displayed selective CO formation over H2, with higher currents compared to pristine Cu2O (−0.34 mA/cm2 for Cu2O and −0.64 mA/cm2 for CU Cu2O/RGO 2:1 at the voltage of −0.8 vs. RHE and in a CO2 atmosphere) and a faradaic efficiency of 50% at −0.9 V vs. RHE. This composition exhibited significantly higher CO production compared to the pristine materials, indicating a favorable *CO intermediate pathway even at lower voltages. The systematic investigation on the effects of nanostructuration on composition, morphology and catalytic behavior is a valuable solution for the formation of effective interphases for the promotion of catalytic properties providing crucial insights for future catalysts design and applications.

Green synthesis of CuO nanoparticles: A promising role of antioxidant and antimicrobial activity by using Tribulus terrestris L

Green synthesis of CuO nanoparticles: A promising role of antioxidant and antimicrobial activity by using Tribulus terrestris L

Preparation of nanocellulose/reduced graphene oxide matrix loaded with cuprous oxide nanoparticles for efficient catalytic reduction of 4-nitrophenol.

The paper reports on the preparation of cellulose nanocrystals/reduced graphene oxide matrix loaded with cuprous oxide nanoparticles (CNC/rGO-Cu2O) through a simple solvothermal method and its application for 4-nitrophenol reduction to 4-aminophenol using sodium borohydride. The CNC/rGO-Cu2O nanocomposite was formed chemically by first mixing CNC and graphene oxide (GO) followed by complexation of the negatively charged functional groups of CNC/GO with Cu2+ ions and subsequent heating at 100°C. This resulted in the simultaneous reduction of GO to rGO and the formation of Cu2O nanoparticles. The as-elaborated nanocomposite was firstly characterized using different techniques such as atomic force microscopy, scanning electron microscopy, transmission electron microscopy, UV-Vis spectrophotometry, Raman spectroscopy and x-ray photoelectron spectroscopy. Then, it was successfully applied for efficient catalytic reduction of 4-nitrophenol to 4-aminophenol using sodium borohydride: the reduction was completed in about 6 min. After eight times use, the catalyst still maintained good catalytic performance. Compared to CNC/rGO, rGO/Cu2O and free Cu2O nanoparticles, the CNC/rGO-Cu2O nanocomposite exhibits higher catalytic activity even at lower copper loading.

Interstitial carbon induces enriched Cuδ+ sites in Cu2O nanoparticles to facilitate CO2 electroreduction to C2+ products

Interstitial carbon induces enriched Cuδ+ sites in Cu2O nanoparticles to facilitate CO2 electroreduction to C2+ products

CRET-based immunoassay on magnetic beads for selective and sensitive detection of Nanog antigen as a key cancer stem cell marker.

Amethod is presentedfor chemiluminescence resonance energy transfer (CRET) using APTES-Fe3O4 as a highly efficient energy acceptor with strong magnetic effectiveness over extended distances, while an Au@BSA-luminol composite acts as the donor. In order to boost the chemiluminescence reactions, CuO nanoparticles were successfully employed. The distance between the donor and acceptor is a crucial factor in the occurrence of the CRET phenomenon. A sensitive and high-throughput sandwich chemiluminescence immunosensor has been developed accordingly with a linear range of 1.0 × 10-7 g/L to 6.0 × 10-5 g/L and a limit of detection of 0.8 × 10-7 g/L. The CRET-based sandwich immunosensor has the potential to be implemented to early cancer diagnosis because of its high sensitivity in detecting Nanog, fast analysis (30 min), and simplicity. Furthermore, this approach has the potential to be adapted for the recognition of other antigen-antibody immune complexes by utilizing the corresponding antigens and their selective antibodies.

In Situ Synthesis of Cu2O Nanoparticles Using Eucalyptus globulus Extract to Remove a Dye via Advanced Oxidation.

Water pollution, particularly from organic contaminants like dyes, is a pressing issue, prompting exploration into advanced oxidation processes (AOPs) as potential solutions. This study focuses on synthesizing Cu2O on cellulose-based fabric using Eucalyptus globulus leaf extracts. The resulting catalysts effectively degraded methylene blue through photocatalysis under LED visible light and heterogeneous Fenton-like reactions with H2O2, demonstrating reusability. Mechanistic insights were gained through analyses of the extracts before and after Cu2O synthesis, revealing the role of phenolic compounds and reducing sugars in nanoparticle formation. Cu2O nanoparticles on cellulose-based fabric were characterized in terms of their morphology, structure, and bandgap via SEM-EDS, XRD, Raman, FTIR, UV-Vis DRS, and TGA. The degradation of methylene blue was pH-dependent; photocatalysis was more efficient at neutral pH due to hydroxyl and superoxide radical production, while Fenton-like reactions showed greater efficiency at acidic pH, primarily generating hydroxyl radicals. Cu2O used in Fenton-like reactions exhibited lower reusability compared to photocatalysis, suggesting deterioration. This research not only advances understanding of catalytic processes but also holds promise for sustainable water treatment solutions, contributing to environmental protection and resource conservation.

Optimized Extraction and Characterization of Allicin from Snow Mountain Garlic and its Anticancer Potential via Allicin-loaded CuO Nanoparticles

This study aimed to optimize the extraction and purification of allicin and to characterize allicin-loaded CuO nanoparticles for potential anticancer applications. Initially, various solvents, including MilliQ water, methanol at different concentrations, and phosphate buffer at varying pH levels, were tested to maximize the yield and purity of allicin. The extraction efficiency was evaluated by measuring the absorbance at 244 nm using UV spectrophotometry. The highest extraction efficiency was achieved with MilliQ water (0.92 ± 0.03) and 40% methanol (0.89 ± 0.05). Additionally, phosphate buffer pH 2.5 in 40% methanol also demonstrated good efficiency (0.86 ± 0.04). Following extraction, the allicin was purified using a glass column to remove impurities, ensuring a high degree of purity for subsequent applications. The chemical structure and purity of the purified allicin were confirmed using fourier-transform infrared spectroscopy (FTIR) and high-performance liquid chromatography (HPLC). To enhance the stability and bioavailability of allicin, allicin-loaded CuO nanoparticles were formulated. Dynamic light scattering (DLS) analysis revealed a mean particle size of 125 nm, while zeta potential measurements indicated a surface charge of -21.74 mV, suggesting good stability. Scanning electron microscopy (SEM) provided detailed insights into the morphology and structure of the nanoparticles. The successful optimization of allicin extraction and purification, coupled with the characterization of allicin-loaded nanoparticles, paves the way for their potential application in cancer therapy. The enhanced stability and bioavailability of allicin through nanoparticle formulation hold promise for improving its therapeutic efficacy against cancer. Further studies are warranted to explore the anticancer activity of these nanoparticles in biological systems.

Customized Green Energetic Tetra(Imidazole)Copper(II) Nitrate (Cu-Im) Complex/Ammonium Nitrate Co-crystal: A Novel Reactive Halogen-Free Oxidizer with Superior Stability and Decomposition Kinetics

AbstractAmmonium nitrate (AN) is the most promising affordable green oxidizer for solid propellants; however, its endothermic phase transitions and endothermic decomposition restrict its applications. This work shaded the light on multifunctional energetic complex tetra(imidazole)copper (II) nitrate (Cu-Im) with combustion enthalpy of 15.57 KJ/g as a high energy dense material, phase stabilizer, and catalyst for AN-based propellant. The Cu-Im complex was synthesized via a green simple solvent-free melt-assisting technique. As-synthesized Cu-Im complex demonstrated a highly pure crystalline structure with thermal stability up to 200 °C. Cu-Im complex was integrated into AN via an evaporative crystallization technique. The phase transitions and the thermal behavior of the developed Cu-Im complex/AN cocrystal were investigated via DSC and TGA. The Cu-Im complex stabilized the phase transition of AN up to 88.48 °C via an evolved strong hydrogen bonding system within the Cu-Im complex/AN cocrystal. Moreover, the energetic Cu-Im complex offered a significant decrease in the endothermic phase transition peaks associated with IV↔II, and II↔I by 38.81%, and 25.28% respectively. Additionally, AN strong endothermic melting was decreased by 45.32%. The Cu-Im complex converts the AN endothermic thermal decomposition peak with + 1400 J/g into an intensive exothermic peak with the release of -2241 J/g. The Cu-Im complex exhibited a superior catalytic effect via the decrease in AN decomposition temperature by 48.85 °C. Cu-Im complex offered a remarkable reduction in apparent activation energy of AN decomposition by 56.24% and 48.12% via Kissinger’s model and integral iso-conversional nonlinear Vyazovkin method (VYA) respectively. The superior catalytic performance of the Cu-Im complex was attributed to the evolution of CuO nanoparticles during its decomposition. The electron-deficient Lewis acid copper ions have a large affinity to electron lone pair of nitrogen; this effect could support the conversion of NH3 to N2 and H2. This catalytic action could boost the decomposition enthalpy of AN. Consequently, the developed Cu-Im/AN cocrystal could be considered a potential green substitute for perchlorate-based oxidizers.

Enhancing Anticancer Potential: Optimization of Allicin Extraction from Regular Garlic and Characterization of Allicin-Loaded Copper Oxide Nanoparticles

This research aimed to optimize the extraction and purification processes of allicin from regular garlic (Allium sativum) and to evaluate the potential of allicin-loaded copper oxide (CuO) nanoparticles for anticancer applications. Initially, various solvents, including MilliQ water, 25% methanol, and phosphate buffer pH 2.5 in 60% methanol, were tested to determine the most effective conditions for extracting allicin. Among these, MilliQ water and 25% methanol demonstrated the highest extraction efficiencies, as evidenced by their absorbance values. The extracted allicin underwent purification and was subsequently characterized using fourier-transform infrared spectroscopy (FTIR) and high-performance liquid chromatography (HPLC). These techniques confirmed the identity and high purity of the allicin. Following purification, the allicin was encapsulated into copper oxide (CuO) nanoparticles using an optimized nanoprecipitation protocol. The physicochemical properties of the allicin-loaded nanoparticles were thoroughly characterized. Dynamic light scattering (DLS) analysis revealed a mean particle size of 123 nm, indicating a uniform and nanoscale particle distribution. Zeta potential measurements indicated a surface charge of -28.34 mV, suggesting good stability of the nanoparticles in suspension. Scanning electron microscopy (SEM) was employed to further analyze the particle size, surface charge, and morphology, providing detailed insights into the structural attributes of the nanoparticles. The successful encapsulation of allicin into CuO nanoparticles not only enhances the stability and bioavailability of allicin but also leverages the unique properties of CuO nanoparticles, which are known for their anticancer, antioxidant, and antimicrobial activities. This study underscores the potential of allicin-loaded CuO nanoparticles derived from regular garlic as a promising formulation for pharmaceutical applications, particularly in the field of oncology. These findings warrant further investigation into their clinical efficacy and safety to fully harness their therapeutic potential.

Green synthesis structural, morphological and sonocatalytic properties of CuO nanoparticles assisted by Camellia sinensis (Tea) extract

In this green synthesis approach for copper oxide (CuO) nanoparticles (NPs), the reducing agent obtained from Camellia sinensis (Tea) extract was used. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), ultraviolet visible (UV-Vis) spectroscopy, field emission scanning electron microscope (FESEM) with energy-dispersive X-ray (EDX), high resolution transmission electron microscope (HRTEM) and Selected Area Electron Diffraction (SAED) techniques were used for as-prepared sample characterization. From XRD result, the crystallite size estimated by Scherrer method was found to be 35 nm. Morphological results reveals that the CuO NPs possesses small particle size with the range of 40–45 nm, led to high surface area, which enhances the absorption of more number of dye molecules, which results in high degradation efficiency. Present work reveals that degradation of malachite green (MG) dye in aqueous solutions under sonocatalytic treatment. CuO NPs exhibit excellent degradation efficiency against MG dye (95 % removal in 70 min). Moreover, the rate constant for the degradation efficiency was investigated with pseudo- first and second order kinetics. Moreover, CuO NPs possesses potential antibacterial activity against human pathogens such as Gram-positive (Staphylococcus pyogenes) and Gram-negative (Pseudomonas aeruginosa).