Previously, the formation of polyhedral Cu2O crystal is usually proposed like that the seed crystals grow outward following the relative growth rates (R values) along different directions (Inside-out Pattern) or that the surrounding building blocks aggregate toward the center followed by ripening (Outside-in Pattern). However, in this study, simply mixing aqueous Cu(CH3COO)2, NaOH, and D-(+)-glucose in the order listed at 70 °C for a period, a distinct growth manner of Cu2O polyhedron was observed based on carefully recording the solution color changes and the elaborate time-dependent SEM/TEM observations, which was referred to All-direction Pattern. More specifically, the initially formed Cu2O nanoshuttles first self-aggregated into porous braided structure with well-defined cubic framework and then condensed into solid cube from all direction via consuming the surrounding fragments everywhere possible, rather than in gradient densification from inside-out or outside-in. After that, the solid cube fell into the common Outside-in Pattern, i.e., adsorbing the surroundings followed by ripening. Although many complex polyhedral submicrostructures have been already reported, to our best knowledge, Cu2O crystal that grows in such manner is barely observed. It is believed that such interesting growth mechanism of polyhedral crystals could be general. What's more, the 30 min-Cu2O powder was made into a gas sensor towards ethanol, the performance of which has reached the level of application.