1) For lateralized tumors, only ipsilateral parapharyngeal space was covered to minimize trismus, 2) Maxillary sinus and ethmoid sinus were not routinely covered unless involved, 3) Pharyngeal airway was omitted to minimize dose to oral cavity and soft palate, thereby minimizing mucositis and velopharyngeal insufficiency, respectively, 4) Sphenoid sinus was not covered routinely unless it was involved or at risk, 5) Level IB was not covered unless involved, 6) Pterygopalatine fossa was always covered, ipsilateral for lateralized and bilaterally for bilateral tumors, 7) Foramen lacerum was always covered bilaterally to prevent recurrence in the cavernous sinus, 8) When foramen ovale was involved, trigeminal ganglion in Meckel’s cave was covered for potential retrograde spread. Results: Between 1991 and 2013, 72 patients with newly diagnosed non-metastatic NPC were treated in our department by two radiation oncologists who employed the specified approach. The T-category distribution (%) was T1 14: T2 17, T3 21, T4 48. The N-category distribution (%) was N0 25, N1 17, N2 48, N3 10. Eighty-seven percent of patients were treated with protons +/photons whereas 13% were treated with IMRT only. The median dose to the GTV primary was 70 Gy (range 69.96-76.8). Twenty-six percent of patients received induction+concurrent whereas 63% of patients received concurrent chemotherapy only. With a median follow-up of 3.2 years, 4 patients developed local recurrence and 1 patient developed regional recurrence. The rates of local and regional control at 3 years were 92.2% (95% CI 85-99.9%) and 98.3% (95% CI, 95-100%), respectively. The distantmetastasis free rate at 3 years was 87.6%. All locoregional recurrences occurred within the high-dose GTVs. Conclusions: Our long-term experience of individualization of CTV delineation based on tumor extent and the orderly pattern of tumor spread results in excellent locoregional control, with no recurrence within the CTV region. Author Disclosure: A.W. Chan: None. M. Kim: None. A.A. Aizer: None. S.M. McBride: None. E. Weyman: None. N.J. Liebsch: None.