The authors present cases of natural death due to arterial or cardiac hemorrhage evaluated using both conventional autopsy examination and post-mortem imaging, including post-mortem computed tomography angiography (PMCTA). Visualization based on CT scan acquisition are presented combined with the results of macroscopic and microscopic examination. Based on cases presented it can be seen that in selected cases PMCTA might be a sufficient method of examination while combined with conventional external examination and toxicological investigation; however, in investigations of alleged medical malpractice cases, histopathological examination of specimens seems to be necessary. There are no doubts that post-mortem imaging differs from clinical examination. As we consider the history and the output of clinical imaging methods, there are plenty of challenges awaiting in the field of post-mortem imaging.