Leather being a natural material finds a most prominent position in the fashion field. Leather goods, garments and products symbolize luxury and comfort. Manufacturing of leather products requires meeting the physical and chemical norms stipulated by the international agencies depending on the end products. Among the various physical properties, sewability is very important in deciding the quality of manufactured products. The present research discusses about the effect of syntan and fatliquor on leather properties. Experiments have been designed with varied concentration of melamine syntan along with 10% fatliquor. Various physical characterizations such as sewability, tensile strength, grain crack and microscopic images have been studied to elucidate the effect of syntan and fatliquor on leather properties. The experimental results show that the presence of fatliquor is a critical component to achieve better sewability properties in leather. Similar effect has been observed in the case of grain crack and tensile strength of the crust leathers. Prosaically, the experimental data have shown that the usage of fatliquor shows better sewability property.