Although manifold empirical studies have identified the mechanical properties of crumb rubber concrete (CRC), a comparative analysis of economic and environmental benefits between CRC and ordinary Portland cement concrete (OPCC) is not explored. In this paper, a quantitative meta-analysis between CRC and OPCC is conducted to explore optimized design strength, and a comparative analysis of the economic and environmental benefits of the two materials is undertaken. Considering cost price as the economic index and CO2 emissions per cubic meter of concrete as the environmental index in the materialization stage, CRC and OPCC were compared with different mix designs to achieve grades of similar strengths. Upon replacing less than 20% of natural fine aggregates in concrete with crumb rubber, while retaining the cement content, an increase of 6% in the cost price was achieved for CRC with 30–40 MPa strength grade. Apart from the aspect of mining and transportation of natural aggregates, the reduction of CO2 emissions by means of CRC adoption was verified in the treatment process of waste tire incineration. The results show that CO2 emissions from CRC decreased by 15–17% when compared with OPCC for 30~40 MPa grade concrete. The research conclusion can serve as a theoretical basis for the engineering application of CRC with the same strength, and make certain contributions to the industrial application of crumb rubber aggregates and the sustainable treatment of waste tires.