In December 2019, a new respiratory disease, i.e., novel Coronavirus (COVID-19) emerged in Mainland China in Wuhan the capital of Hubei Province. It spreads through droplets produced while coughing or sneezing. Its symptoms include fever, dry cough, fatigue, sputum production, shortness of breath, sore throat, etc. In March 2020, the World Health Organization (WHO) declared COVID-19 as a “Pandemic” which affected human lives and economies. South Sudan is a developing country and does not have adequate resources to overcome this pandemic (COVID-19).
 Aims: The primary objective of this article is to explore the impact of COVID-19 on the youngest country in the African continent (South Sudan) on its weak economy coupled with hyperinflation and depreciation of currency etc. and lessons learned from other countries in the fight against the COVID-19 pandemic.
 Methodology: A review was carried out to accomplish the objective of the study by extracting data from the database of Science Direct, Web of Science, Google Scholar, Research Gate, and authentic websites for World Health Organization (WHO), World Bank, etc., studies covered major areas across the globe but more especially countries that have trade ties with South Sudan and the East African
 Results: There is a drop in South Sudan’s crude oil export which is crucial for the economy. The responsive rate to vulnerable citizens was low, inadequate policies implementations, there was massive unemployment, it has created the state of xenophobia between nationals and foreigners, online learning through the use of televisions (TVs) and radio stations has not been effective.
 Conclusion: The management of the COVID-19 pandemic call for collaboration between authorities the public, and inter-states as there is no country immune. The use of e-commerce is crucial for developing countries, which reduces social interaction between traders and consumers, reducing the chances of a complete economic shutdown. Lastly, there is also a need to establish learning infrastructures for online studies and birth control initiatives, especially for the least developed countries.
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