541 Background: Cancer is a life-threatening disease and often associated high out-of-pocket (OOP) costs. Cancer patients may forgo or delay medical care because of costs and struggle to afford other basic needs in the US. Crowdfunding can help people cover OOP costs and daily living expenses, such as food, housing, and transportation. GoFundMe is one of the most utilized crowdfunding platforms for personal medical reasons in the last decade. However, little is known about the money raised on GoFundMe and the relative portion of cancer-related campaigns. Methods: The 2012-2022 crowdfunding campaigns were collected from the GoFundMe website using a distributed web scraper. The downloaded data was parsed to extract campaign details such as category, organizer information, fundraiser story, fundraising goal, amount of money raised, and donation records. Preprocessing steps were applied to remove duplicate records or invalid entries. Offline donations were excluded from analyses due to the inability to verify transactions. Additionally, campaigns with over 1000 donations were removed from analyses because GoFundMe website only provides a maximum of 1000 donations per campaign, which accounts for a small proportion (<0.01%) of total number of campaigns. Results: About 2.3 million crowdfunding campaigns were retrieved, of which 490,008 (21.3%) fund-raising events were due to personal medical reasons. In sum, there were 33 million donation records and 3.4 billion dollars were raised for personal medical reasons, and the average amount was $6,893 per campaign. The annual amount of money raised increased over time, from about $655k in 2012 to $68.4 million in 2022. About 15.6% campaigns reached their fundraising goals. California, Texas, and New York – three of the most populous states - were the top three states in terms of the total amount of money raised. Cancer-related fundraising events accounted for 41.1% of all medical campaigns (n=201,474) with a total amount of $1.6 billion raised, and the average amount of money raised was $7,994 (Table). All monetary values were nominal dollars without inflation adjustment. Conclusions: A growing number of individuals resort to GoFundMe for personal medical reasons, and cancer-related campaigns are the most common, underscoring the financial vulnerability of patients with cancer and their families in the US. The annual amount of money raised increased substantially in the last decade. However, only a small percentage of campaigns reach their financial goals. Future research analyzing fundraiser stories to understand the contents and severity of financial hardship caused by cancer in this population are warranted.[Table: see text]