We report a detailed analysis of the electron-impact double ionization process for Be-like ions, spanning charge states from B+ to Ne6+. We considered both direct and indirect double ionization processes. For direct double ionization, we calculated the cross sections by considering three different processes: ionization-ionization (II), excitation-ionization-ionization (EII), and ionization-excitation-ionization (IEI). Our results show excellent agreement between the measured cross sections for Be-like-B and Be-like-O ions. The agreement is slightly weaker for Be-like-Ne ions when we take the potential of ionized ions in the distorted-wave method. For other ions for which experimental data are not available, our calculations should provide the missing data. We have summarized the trends of electron-impact double ionization cross sections with atomic number for isoelectronic sequences. Finally, we have provided the Maxwellian and non-Maxwellian rate coefficients for these Be-like ions. The data obtained should be useful for both equilibrium and non-equilibrium charge-state distributions in astrophysical research.