In this study, we reported the radiation protection characteristics of TeO2-WO3-ZnF2 glass systems with different compositions. The composition of the glasses are (0.8 - x) TeO2– 0.2WO3–xZnF2, 0.7TeO2-0.1WO3-0.2-ZnF2 and 0.6TeO2-0.15WO3-0.25ZnF2 (where x = 0.1,0.2,0.3). The radiation shielding parameters including mass attenuation coefficient (MAC), linear attenuation coefficient (LAC), half value layer (HVL), mean free path (MFP), tenth value layer (TVL), effective atomic number (Zeff), effective electron number (Neff), and atomic and electronic cross sections (ACS and ECS) have been determined for the prepared glasses against a broad range of ionizing energy between 0.015 and 15 MeV. The structure of the prepared glasses was investigated by using Raman spectra. It obtained that, the incorporation of WO3 into the TeO2 glass network causes the creation of W–O–W connections, while Te–O–W linkages with greater electronic polarizability improve the glass network's connectedness. The study demonstrates that the TeO2-WO3- ZnF2 glass system can be utilized for radiation protection against ionizing radiation in a variety of medical and technical applications.