Relation classification is one of the most fundamental tasks in the area of cross-media, which is essential for many practical applications such as information extraction, question&answer system, and knowledge base construction. In the cross-media semantic retrieval task, in order to meet the needs of cross-media uniform representation and semantic analysis, it is necessary to analyze the semantic potential relationship and construct semantic-related cross-media knowledge graph. The relationship classification technology is an important part of solving semantic correlation classification. Most of existing methods regard relation classification as a multi-classification task, without considering the correlation between different relationships. However, two relationships in the opposite directions are usually not independent of each other. Hence, this kind of relationships are easily confused in the traditional way. In order to solve the problem of confusing the relationships of the same semantic with different entity directions, this paper proposes a neural network fusing discrimination information for relation classification. In the proposed model, discrimination information is used to distinguish the relationship of the same semantic with different entity directions, the direction of entity in space is transformed into the direction of vector in mathematics by the method of entity vector subtraction, and the result of entity vector subtraction is used as discrimination information. The model consists of three modules: sentence representation module, relation discrimination module and discrimination fusion module. Moreover, two fusion methods are used for feature fusion. One is a Cascade-based feature fusion method, and another is a feature fusion method based on convolution neural network. In addition, this paper uses the new function added by cross-entropy function and deformed Max-Margin function as the loss function of the model. The experimental results show that the proposed discriminant feature is effective in distinguishing confusing relationships, and the proposed loss function can improve the performance of the model to a certain extent. Finally, the proposed model achieves 84.8% of the F1 value without any additional features or NLP analysis tools. Hence, the proposed method has a promising prospect of being incorporated in various cross-media systems.