Due to low adoption and sub-optimal fertilizer use and planting density recommendation in maize, redesigning and testing these technologies are required. The study was conducted to evaluate redesigned fertilizer use of maize in two pant densities (32,443 and 53,333 plants ha-1 in Central Rift Valley (CRV); 27724 and 62,000 plants ha-1 in Jimma) on farmers' fields in contrasting agro-ecologies of Ethiopia. The on-farm study was conducted in the 2017 and 2018 cropping seasons with 3 × 2 fertilizer and plant density, factors in both regions of Ethiopia. In redesigned fertilizer use, nutrients were estimated based on the target yield. In this study, 40.8, 0.0, and 12.2 kg ha-1 N, P, and K were estimated for the redesigned fertilizer use in CRV (50% of water-limited potential yield (Yw) = 3.1 t ha-1) whereas in Jimma (50% of Yw = 7.5 t ha-1) 149.8, 9, 130.6 kg ha-1 N, P and K were estimated to produce the 50% of Yw. Linear mixed modeling was used to assess the effect of fertilizer-plant density treatments on maize yield and nutrient use efficiency. The result revealed that the average estimated maize yield for WOF, FFU, and RDFU fertilizer treatments were 2.6, 3.6, and 4.5 t ha-1 under current plant density (32,443 plants ha-1) in CRV whereas the average yields of these treatments were 3.2, 4.5 and 4.5 t ha-1 respectively when maize was grown with redesigned plant density (53,333 plants ha-1) in the same location. The average maize yield with WOF, FFU, and RDFU were 3.0, 4.6, and 4.6 t ha-1 with 27,774 plants ha-1 plant density in Jimma whereas the average maize yields over the two seasons with the same treatments were 4.3, 6.0 and 8.0 t ha-1 respectively when the crop is planted with 62,000 plants ha-1 plant density. The RDFU and redesigned plant density resulted in significantly higher yield compared to their respective control CRV but RDFU significantly increased maize yield when it was planted at redesigned (62,000 plant ha-1) in Jimma. FFU and RDFU were economically viable and redesigned plant density was also a cheaper means of improving maize productivity, especially in the Jimma region. Soil organic carbon and N were closely related to the grain yield response of maize compared to other soil factors. In conclusion, this investigation gives an insight into the importance of redesigned fertilizer use and redesigned plant density for improving maize productivity and thereby narrowing the yield gaps of the crop in high maize potential regions in Ethiopia like Jimma.