Farmers' awareness and the incidence of climate change are crucial inputs to effectively scale up interventions to mitigate the effects of climate change. This is because incidence leads to awareness due to observation of occurrences. The purpose of this paper is to examine the determinants of climate change awareness and incidence across farming systems and agroecological zones in Sierra Leone. An ex-post-facto research design was applied, while a multistage sampling procedure was used to select 865 smallholder farmers across agroecological zones and farming systems. Data were collected with a structured questionnaire subjected to face validity and split-half reliability tests. This data analyzed frequency counts, percentages, multiple regression, and principal component analysis. The results show that farmers in the coastal plain, savannah woodland, and transitional rainforest had greater awareness and incidence of climate change across the crop, livestock, and fishery farming systems. The significant determinants of awareness and incidence of climate change among farmers are the adoption of crop smart practices (t = 4.192; p < 0.01); information needs on water smart practices (t = −5.581; p < 0.01); adoption of nutrient smart practices (t = 10.592; p < 0.01); adoption of energy/carbon smart practices (t = 3.206; p < 0.01); adoption of livestock smart practices (t = 3.608; p < 0.01); information needs on weather smart practices (t = 3.505; p < 0.01); incidence of climate change (t = 16.282; p < 0.01); and constraints on nutrient smart practices (t = −2.669; p < 0.01). The Principal Component analysis identified four factors, namely Factor 1 (Impact), Factor 2 (Occurrence), Factor 3 (Evidence), and Factor 4 (Threat), and accounted for 14.96%, 8.27%, 6.41%, 3.50% of the variance, respectively, with a cumulative variance of 33.14%. The study concludes that farmers are aware of the incidence of climate change and are adopting different techniques in response to the different climate changes observed. This study also recommends the identification of specific climate change adaptations and the scaling of interventions for adaptation and mitigation.