Critical Updates Research Articles

UNIFIDE EMPLOYEE DATA TEAM TRCKER

Abstract : A Team Track: “Unified Employee Data” provides a thorough overview of important metrics, tasks, and insights pertinent to each individual’s function inside a business, acting as a centralized center for them. With the use of this digital technology, staff members can easily access critical information, improving productivity, efficiency, and transparency all around. Fundamentally, an employee dashboard compiles information from multiple sources—such as project management software, HR systems, and performance metrics—and presents it in an intuitive manner. Employees can monitor their progress, evaluate critical updates, and remain up to date on company-wide efforts thanks to this consolidation. With its many features and functionalities, the employment dashboard acts as a focal point for effective job matching and recruitment. The dashboard uses data analytics and state-of-the-art technology to give users real-time insights into market trends, demand signals, and talent assessments. This allows users to make well-informed decisions regarding their hiring strategies and career routes. The dashboard gives staff members the ability to efficiently manage their obligations by giving them access to training materials and project timetable tracking.Additionally, the employee dashboard encourages teamwork and communication. Through the provision of real-time project progress updates Yes, the following are some important details you should provide in an abstract regarding an employee dashboard: Overview: Give a succinct explanation of the purpose of an employee dashboard in contemporary work environments. Mention how it provides a consolidated platform where staff members may access a range of tools, services, and data pertaining to their jobs and companies. Features: Emphasize the key elements that are commonly present in an employee dashboard, such as customized employee profiles, task management tools, collaboration features, access to corporate announcements, HR papers, and payroll data. Benefits: Talk about how having an employee dashboard can lead to better decision-making through real-time data analytics, increased productivity through streamlined resource access, improved communication and transparency within the company, and enhanced employee engagement. Index Terms – Chatgpt, AI tool, Java script

Construction Worker Hiring Management System

The Integrated Construction Management System (ICMS) is a sophisticated web-based application developed to optimize the management processes associated with construction projects. Leveraging a technology stack that includes HTML, CSS, Bootstrap, PHP, and MySQL, this system aims to streamline communication, collaboration, and resource management within construction teams, ultimately contributing to the successful and efficient completion of projects. One of the primary features of ICMS is its robust user authentication and authorization system. The application implements a secure login mechanism that authenticates users while assigning distinct access levels based on their roles within the construction project. This ensures that project managers, architects, engineers, and other stakeholders have tailored access to relevant information and functionalities. The project dashboard serves as a centralized hub, providing a comprehensive overview of the project's status, milestones, and critical updates. Through real-time tracking of project progress, ICMS facilitates effective decision-making by offering stakeholders immediate insights into the current state of affairs. This dynamic approach extends to task and resource management, where tasks can be created, assigned, and tracked in real time, ensuring optimal workforce utilization

Critical updates in neuroendocrine tumors: Version 9 American Joint Committee on Cancer staging system for gastroenteropancreatic neuroendocrine tumors.

The American Joint Committee on Cancer (AJCC) staging system for all cancer sites, including gastroenteropancreatic neuroendocrine tumors (GEP-NETs), is meant to be dynamic, requiring periodic updates to optimize AJCC staging definitions. This entails the collaboration of experts charged with evaluating new evidence that supports changes to each staging system. GEP-NETs are the second most prevalent neoplasm of gastrointestinal origin after colorectal cancer. Since publication of the AJCC eighth edition, the World Health Organization has updated the classification and separates grade 3 GEP-NETs from poorly differentiated neuroendocrine carcinoma. In addition, because of major advancements in diagnostic and therapeutic technologies for GEP-NETs, AJCC version 9 advocates against the use of serum chromogranin A for the diagnosis and monitoring of GEP-NETs. Furthermore, AJCC version 9 recognizes the increasing role of endoscopy and endoscopic resection in the diagnosis and management of NETs, particularly in the stomach, duodenum, and colorectum. Finally, T1NXM0 has been added to stage I in these disease sites as well as in the appendix.

Mechanisms of Sepsis-Induced Acute Lung Injury and Advancements of Natural Small Molecules in Its Treatment.

Sepsis-induced acute lung injury (ALI), characterized by widespread lung dysfunction, is associated with significant morbidity and mortality due to the lack of effective pharmacological treatments available clinically. Small-molecule compounds derived from natural products represent an innovative source and have demonstrated therapeutic potential against sepsis-induced ALI. These natural small molecules may provide a promising alternative treatment option for sepsis-induced ALI. This review aims to summarize the pathogenesis of sepsis and potential therapeutic targets. It assembles critical updates (from 2014 to 2024) on natural small molecules with therapeutic potential against sepsis-induced ALI, detailing their sources, structures, effects, and mechanisms of action.

How News Found the Avoiders: The Changing News Routines of Infodemically Vulnerable Young People in England During Covid-19

ABSTRACT This article examines how young people (18–24) in England who experience social inequality consumed news during the first national Covid-19 lockdown. Described as “infodemically vulnerable” due to their reliance on social media for news, I draw on 25 interviews to consider if this underresearched population was exposed to harmful information. Contrary to fears, participants maintained a constant awareness of essential Covid-19 information throughout this period. They used substantively different consumption practices as the lockdown progressed. Initially, interviewees turned to trusted information from broadcast media news, replacing their dependence on social media. This was short-lived, as participants later avoided television news due to its impact on their wellbeing and frustrations that coverage did not relate to their lived experience. The paper demonstrates how structural factors, like age and inequality, can act as catalysts for selective news avoidance. Avoidance, however, did not result in interviewees missing critical updates. They adopted a “News Finds Me” perception, whereby individuals remained informed indirectly through relatable information from trusted contacts received on private messaging applications. Rather than being exposed to an infodemic, this article shows how accidental exposure to news on social media provided information perceived as more useful and representative of their lived experience.

Frontline treatment options for higher-risk MDS: can we move past azacitidine?

Although remarkable international efforts have been ongoing for over 17 years to improve upon azacitidine, representing the standard of care therapy for higher-risk myelodysplastic neoplasms (MDS), there still has not been a positive randomized trial in comparison to azacitidine. Real-world data from numerous trials have shown similar results with a median overall survival of 14-18 months, a 40%-50% overall response rate, and a complete remission rate close to 20%. Despite these outcomes, 6 randomized controlled trials have failed to improve outcomes in this patient population, although relevant issues in some of these studies included improper dose adjustments of the hypomethylating agent, lack of placebo- controlled studies, and lack of overall survival (OS) as a primary endpoint, among others. Critical updates in MDS management include the development of molecular prognostication models (eg, the molecular international prognostic scoring system), updates in classification systems highlighting significant overlap in patients with MDS-increased blasts and acute myeloid leukemia (most relevant to TP53 mutations), and refinement of response criteria. Although these paradigm-shifting studies have had great impact in MDS management, the current ongoing randomized phase 3 trials were initiated prior, and prognostic stratification remains via the revised international prognostic scoring system) and with bone marrow blast counts of <20%. Notably, azacitidine + venetoclax, azacitidine + sabatolimab, and azacitidine + magrolimab have shown exciting results in large, single-arm studies and have completed accrual in placebo-controlled, double-blind studies with OS as a primary endpoint. We all eagerly await the results of these studies.

Third-party software library migration at the method-level using multi-objective evolutionary search

Software developers commonly use third-party software libraries to reduce implementation efforts and mitigate errors in their source code while building high-quality and reliable software. To support software evolution, newer libraries are released periodically with added features, improvements in performance as well as critical updates such as bug fixes. Hence, older, existing (source) libraries need to be replaced with their newer, updated (target) counterparts, in a process known as library migration. Typically, library migration is a time-consuming, manual, and error-prone process that requires developers to analyze the source and target library code and its documentation. Specifically, developers examine Application Programming Interface (API) implementations and documentation to replace each source API with a target API without modifying the underlying software functionality. While recent works have used various techniques to recommend suitable target library replacements, these approaches do not generalize well, e.g., when a source library method needs to be replaced by one or more target library APIs or methods. To address this limitation, we propose the use of multi-objective evolutionary algorithms to identify suitable method replacements during library migration. In particular, we formulate library migration at the method-level as a multi-objective combinatorial optimization problem and examine the performance of 7 multi-objective evolutionary algorithms: UNSGAIII, RNSGAII, AGEMOEA, SMSEMOA, NSGAII, IBEA and MOEAD. We use method signature and documentation similarity, and co-occurrence probability to accurately recommend one or more target library methods. We evaluate our approach by conducting an empirical study on 9 popular Java library migrations mined from 57,447 open-source projects on GitHub. Our results demonstrate that UNSGAIII, RNSGAII, AGEMOEA, SMSEMOA, NSGAII, IBEA and MOEAD achieve 90%, 89%, 94%, 90%, 91%, 94%, and 71% precision on average, and 83%, 23%, 58%, 63%, 58%, 60% and 17% average recall respectively. In the interest of reproducibility, we make all code and results publicly available at: http://bit.ly/MOO-api-migration.

Significance of Nutrition Facts Label of Food Products with Critical Updates by FDA on Nutrition Facts Label

Significance of Nutrition Facts Label of Food Products with Critical Updates by FDA on Nutrition Facts Label

News Alert App

The News Alert Android App is a revolutionary mobile application designed to keep users informed with real- time access to breaking news from across the globe. With its user-friendly interface, the app ensures that users can easily navigate through various news categories and receive instant notifications for critical updates and emergencies. Offering personalized news preferences, users can customize their experience by selecting specific topics, regions, or industries of interest. Beyond text-based news, the app provides multimedia content, including images and videos, to enhance the storytelling experience. Social media integration allows users to share news updates with their networks, encouraging meaningful discussions and raising awareness about important issues. With AI-driven algorithms, the app delivers smart notifications to avoid overwhelming users with redundant or irrelevant information. Whether online or offline, users can access up-to-date news, bookmark articles, and stay connected to the world's events. The News Alert Android App is a powerful tool for those seeking timely and reliable information, fostering an informed and engaged community in today's fast-paced information age. The news alert app includes modules like home, science technology, sports, health, entertainment for users. Keyword: Real-Time News Delivery, User Experience, User- Centric Design, Push Notification.

Truth Tables, True Distinctions. Paradoxes of the Source Code of Science.

On the occasion of a growing popularity of paradox theory in management and organisation research, this article provides an introduction to the paradox of true distinctions, reports on its relevance to theory building, and presents a strategy to contain the paradox without resolving it. To this end, I draw on works by George Spencer Brown and Niklas Luhmann to contextualize theory within the paradox of observation in general and the paradox of scientific observation in particular. A special case of the paradox of scientific communication, paradox theory is then redefined as a scientific programme fascinated with the paradoxical nature of the basic operation of science. I conclude that further development work on the "source code" of science will provide "critical updates" on the opportunities and limits to metatheoretical extensions of theories of management, organisation, and society, including their digital transformation.

Evolution of the uniformly white sclera in humans: critical updates.

The human eye characteristically has exposed and uniformly white sclera, which is hypothesized to have evolved to enhance eye-gaze signaling for conspecific communication. Although recent studies have put this hypothesis into question, current morphological and experimental evidence supports its key premise, albeit with recommendations for critical updates.

Serotype Screening of Salmonella enterica Subspecies I by Intergenic Sequence Ribotyping (ISR): Critical Updates

(1) Background: Foodborne illness from Salmonella enterica subspecies I is most associated with approximately 32 out of 1600 serotypes. While whole genome sequencing and other nucleic acid-based methods are preferred for serotyping, they require expertise in bioinformatics and often submission to an external agency. Intergenic Sequence Ribotyping (ISR) assigns serotype to Salmonella in coordination with information freely available at the National Center for Biotechnology Information. ISR requires updating because it was developed from 26 genomes while there are now currently 1804 genomes and 1685 plasmids. (2) Methods: Serotypes available for sequencing were analyzed by ISR to confirm primer efficacy and to identify any issues in application. Differences between the 2012 and 2022 ISR database were tabulated, nomenclature edited, and instances of multiple serotypes aligning to a single ISR were examined. (3) Results: The 2022 ISR database has 268 sequences and 40 of these were assigned new NCBI accession numbers that were not previously available. Extending boundaries of sequences resolved hdfR cross-alignment and reduced multiplicity of alignment for 37 ISRs. Comparison of gene cyaA sequences and some cell surface epitopes provided evidence that homologous recombination was potentially impacting results for this subset. There were 99 sequences that still had no match with an NCBI submission. (4) The 2022 ISR database is available for use as a serotype screening method for Salmonella enterica subspecies I. Finding that 36.9% of the sequences in the ISR database still have no match within the NCBI Salmonella enterica database suggests that there is more genomic heterogeneity yet to characterize.

Automatic control of AC bridge-based capacitive strain sensor interface for wireless structural health monitoring

Thin film-based flexible strain sensors have various advantages for structural health monitoring (SHM) because of their capability to sustain large deformations and cover large area of structural surfaces, making them ideal candidates for applications to complex geometries and structural crack monitoring. The authors previously developed a flexible strain sensor technology based on a soft elastomeric capacitor (SEC) for SHM and investigated an alternating current (AC) bridge-based method to transform the strain-induced dynamic capacitance changes in the SEC into analog voltage signals. Previous experiments have verified the capability of the SEC and the AC bridge-based signal converter for structural strain sensing applications. However, careful manipulation requirement for precise AC-bridge balancing, signal amplification control, and shunt calibration limits its practical use for full-scale SHM in field conditions. This study addressed such limitations with critical updates in both hardware and software with fully automated features for high-sensitive capacitive strain sensing. Newly developed hardware and software are fully controlled with a low-cost microcontroller ATmega328p in an automated way. A series of lab tests validated the prototype's performances in the capacitive strain sensing, outperforming an off-the-shelf wired capacitance measurement system (about 34% lower measurement noise), and confirmed that automatic control features worked as designed.

Abstract #1182744: Home Infusion Administration and Clinical Monitoring Experience of Teprotumumab-trbw in Thyroid Eye Disease (TED) Patients by a Home Infusion Specialty Pharmacy

Thyroid Eye Disease (TED) is an autoimmune disorder that attacks the muscle and fat tissue behind the eye, causing inflammation with subsequent scar tissue development, leading to proptosis, strabismus, and diplopia. In January 2020, the Food and Drug Administration approved teprotumumab-trbw (Tepezza®) for TED, a monoclonal antibody that blocks the IGF-1R autoantibody, decreases proptosis, and is administered over 8 infusion cycles every 3 weeks. This analysis describes the clinical monitoring experience for patients receiving Tepezza® from this home infusion specialty pharmacy. Clinical follow-up of Tepezza® patients in the home infusion arena is conducted by a care team of pharmacists and nurses collaborating with the physician. Using a proprietary clinical database (SoleMetrics®) driven by specific disease and medication assessments, patients are assessed for quality of life (QOL) measures, photos (front, right, left) and therapy outcomes. Soleo Health has serviced over 400 Tepezza® patients safely in the home. SoleMetrics® uses disease-specific assessments to monitor patients throughout their therapy. Patients are assessed prior to every dispense by either a nurse at the bedside or by a pharmacy clinician with disease state training. The assessment includes medication adherence, efficacy of the therapy, adverse event management, barriers to administration, Graves’ Ophthalmopathy Quality of Life Questionnaire (GO-QOL) Visual Functioning and Appearance Subscales, Soleo Overall Wellness Scale, and patient photos. Trended reports are provided to the prescribing physician as assessments are completed. This provides critical updates to the physician between office visits. Clinicians identified 76 opportunities for interventions through the assessment process. Interventions are defined as outreaches to the physician based on patient data collected during the assessment process. Interventions were related to dosage optimization based on weight changes, adverse reaction management, therapeutic response, drug interactions, and financial concerns. Interventions resulted in dosage changes, additional or deleted medications, and additional patient counseling or teaching. TED can be devastating for patients creating low self-esteem and poor perception of appearance. Providing the patient and the physician with QOL scores and photo documentation of changes during and after treatment provides the patient with evidence the therapy is working while helping with therapy adherence. Continuous monitoring and collaboration with patients, caregivers, and physicians will ensure optimal patient outcomes.

Molecular Diagnostic Outcomes from 700 Cases: What Can We Learn from a Retrospective Analysis of Clinical Exome Sequencing?

Clinical exome sequencing (CES) aids in the diagnosis of rare genetic disorders. Herein, we report the molecular diagnostic yield and spectrum of genetic alterations contributing to disease in 700 pediatric cases analyzed at the Children's Hospital of Philadelphia. The overall diagnostic yield was 23%, with three cases having more than one molecular diagnosis and 2.6% having secondary/additional findings. A candidate gene finding was reported in another 8.4% of cases. The clinical indications with the highest diagnostic yield were neurodevelopmental disorders (including seizures), whereas immune- and oncology-related indications were negatively associated with molecular diagnosis. The rapid expansion of knowledge regarding the genome's role in human disease necessitates reanalysis of CES samples. To capture these new discoveries, a subset of cases (n=240) underwent reanalysis, with an increase in diagnostic yield. We describe our experience reporting CES results in a pediatric setting, including reporting of secondary findings, reporting newly discovered genetic conditions, and revisiting negative test results. Finally, we highlight the challenges associated with implementing critical updates to the CES workflow. Although these updates are necessary, they demand an investment of time and resources from the laboratory. In summary, these data demonstrate the clinical utility of exome sequencing and reanalysis, while highlighting the critical considerations for continuous improvement of a CES test in a clinical laboratory.

Drones reveal spatial patterning of sympatric Alaskan pinniped species and drivers of their local distributions

The Arctic and its adjacent ecosystems are undergoing rapid ecological reorganization in response to the effects of global climate change, and sentinel species provide critical updates as these changes unfold. This study leverages emerging remote sensing techniques to reveal fine-scale drivers of distribution and terrestrial habitat use of two sympatric sentinel species of the central Bering Sea, the Pacific harbor seal (Phoca vitulina richardii (Gray, 1864)) and the northern fur seal (Callorhinus ursinus (Linnaeus, 1758)), at non-breeding haul-outs in the Pribilof Islands. We surveyed these species using unoccupied aircraft systems with thermal and visible-light photography, and we applied distributional modeling techniques to quantify the relative influence of habitat characteristics and social dynamics on the local distributions of these species. Drone imagery yielded locations and population counts of each species, and spatial data products allowed quantitative characterization of occupied sites, revealing that conspecific attraction is a driver of local site selection for both species, and Pacific harbor seals and northern fur seals are differentially limited by terrain characteristics. These findings represent new applications of species distribution modeling at local scales, made possible by ultra-high resolution drone surveillance and photogrammetric techniques, which add new spatial context to past observations and future scenarios in this changing ecosystem.

Generalized Anxiety Disorder and Depressive Symptoms among Pakistani Population during the Second Wave of the COVID-19 Pandemic: A Regression Analysis.

ABSTRACT.Over a span of 1 year, with millions infected, COVID-19 has spread to every part of the world and now poses a health threat to each and every one of us. The outbreak has consequently resulted in multiple health problems such as stress, anxiety, depressive symptoms, insomnia, panic, and denial globally. Several factors have contributed to this rising number of psychiatric consults all over the world. The primary objective of this study was to investigate the impact of COVID-19 pandemic on the mental health of Pakistani population during the second wave of the pandemic in this region. We conducted an online web-based cross-sectional survey comprising 500 participants. The questionnaire assessed the demographic information, attitude, and knowledge concerning COVID-19 outbreak in addition to generalized anxiety disorder (GAD) utilizing the GAD-7 scale and depressive symptoms using the Center for Epidemiology Scale for Depression (CES-D) scale. The response rate of the study was 90.9%. The results of the survey indicated a prevalence of 25.4% of GAD, and 18.8% of depressive symptoms. Furthermore, nearly 34.8% of participants feared contracting COVID-19, 62.8% obtained constant critical updates regarding COVID-19, while 17.6% did not understand the knowledge regarding COVID-19. In the multivariate regression models, GAD was significantly associated with gender, age, and checking constantly of critical updates regarding COVID-19. Similarly, participants under 30 years had a higher risk of developing depressive symptoms than those above (> 30 years). Lastly, participants with no formal education were also found to be more prone to developing depression. We identified a potential threat to mental health during the pandemic.

The anti-money laundering act of 2020

Purpose The purpose of this article is to inform stakeholders about the Anti-Money Laundering Act of 2020 (AMLA), explain its impact on the U.S. anti-money laundering (AML) regime, and highlight critical updates for financial institutions. Design/methodology/approach The article provides an overview of the AMLA, and specifically addresses three key components: (1) the development of uniform beneficial ownership requirements and the creation of a beneficial ownership registry at the Financial Crimes Enforcement Network (FinCEN); (2) the expansion of FinCEN’s powers and the Bank Secrecy Act/AML program requirements; and (3) new subpoena powers with potential extraterritorial effect granted to the U.S. Secretary of the Treasury and the U.S. Attorney General for documents located at foreign banks that have a correspondent banking account in the U.S. The article also notes the purpose and goals of the AMLA. Findings The AMLA is the first major overhaul of the U.S. AML regime since the 2001 USA PATRIOT Act, and is designed to strengthen national security, protect the financial system, and simplify compliance obligations. The beneficial ownership reporting requirements represent an effort to combat illicit financial activity conducted by shell companies formed and registered in the U.S. Originality/value The article provides financial institutions with a brief overview of a lengthy new law that will impact their AML compliance obligations. Financial institutions should be on alert for forthcoming regulations.

Poéticas de arquivo como práticas urbanas: três gestos de pesquisa no arquivo do Laboratório de Fotodocumentação Sylvio de Vasconcellos

Este texto apresenta três gestos de pesquisa (ampliar, desmontar e desviar) que realizamos no arquivo fotográfico do Laboratório de Fotodocumentação Sylvio de Vasconcellos, a fim de evidenciar aspectos que instituem um campo de debates em torno da cidade, da técnica e do cotidiano. Operamos com fontes provenientes do Serviço de Fotodocumentação da Escola de Arquitetura da Universidade Federal de Minas Gerais, majoritariamente dos anos de 1954 a 1964. Os gestos de pesquisa, enquanto poéticas, experimentam modos de “fazer o arquivo falar”. E provocam ruídos quando colocam em discussão a vida ordinária capturada por meio da fotografia e as implicações dessa mediação técnica na prática da cidade e na construção de representações e discursos. Ao perfurarem o dispositivo do arquivo patrimonial e incidirem na trama histórica em torno do popular, esses gestos vislumbram atualizações críticas em torno do descarte e são também práticas urbanas na medida em que instauram outros modos de ver a cidade (ou des-vê-la, nos termos de Manoel de Barros e Rita Velloso).

Poetics of Archive as Urban Practices: Three Research Gestures in the Archive of the Photo-Documentation Laboratory Sylvio de Vasconcellos

This article presents three research gestures (enlarging, dismantling and diverting) undertaken at the photographic archive of the Sylvio de Vasconcellos Photo-Documentation Laboratory, in order to highlight aspects that have established a field of debate regarding city, technique and everyday life. This was engaged upon with sources from the Photo-Documentation Service in the School of Architecture at the Universidade Federal de Minas Gerais, chiefly from the years 1954 to 1964. The research gestures, as poetics, experimented with ways of “making the archive speak”. They also provoked sounds when they brought into discussion the ordinary life captured through photography, and the implications of this technical mediation in the practice of the city and in constructing representations and discourses. By penetrating the devices of the patrimonial archive and focusing on the historical plot surrounding the vernacular, these gestures have glimpsed critical updates of what was discarded, and are also urban practices to the extent that they establish other ways with which to see the city (or un-see it, in the terms of Manoel de Barros and Rita Velloso).