Critical Stage Research Articles

Estimating evapotranspiration and drought dynamics of winter wheat under climate change: A case study in Huang-Huai-Hai region, China

Drought is one of the vital meteorological disasters that influence crop growth. Timely and accurately estimating the drought dynamics of crops is valuable for decision-maker to formulate scientific management measures of agricultural drought risk. In this study, the evapotranspiration and drought dynamics of winter wheat from 1981 to 2020 in the Huang-Huai-Hai (HHH) region of China were evaluated based on long-term multi-source observation data. Four key developmental stages of winter wheat were given attentions: growth before winter stage, overwintering stage, stage of greening-heading, and stage of filling-maturity. The crop water deficit index (CWDI) on a daily scale was established for quantitatively appraising the impacts of drought on winter wheat. Our results indicated that interannual variation in reference crop evapotranspiration (ET0) during the growth season of winter wheat from 1981 to 2020 in the HHH region showed a slight increase trend, with an average of 602.4 mm and obvious spatial differences of decreasing from the Northeast to the Southwest. Over the past forty years, the winter wheat in the HHH region was most severely affected by severe drought, followed by moderate drought, and finally mild drought. In addition, the impacts of drought on winter wheat at different critical growth stages varied greatly. For the growth before winter stage, the winter wheat was mainly threatened by mild, moderate, and severe droughts. For the overwintering stage, the winter wheat was mainly threatened by moderate, severe, and extreme droughts. For the greening-heading stage, the winter wheat was mainly threatened by mild, moderate, severe, and extreme droughts. For the filling-maturity stage, the winter wheat was mainly threatened by mild and moderate droughts. Finally, the impacts of drought on winter wheat during 1981–2020 in the HHH region were revealed to differ extraordinarily in space. In particular, the areas of winter wheat affected by severe drought significantly decreased. However, the areas of winter wheat affected by moderate drought clearly expanded. Our findings provide new insights for further improving climate change impact studies and agricultural drought defense capabilities adapting to continuous environmental change.

Projecting Climate Change Impact on Precipitation Patterns during Different Growth Stages of Rainfed Wheat Crop in the Pothwar Plateau, Pakistan

In rainfed areas, precipitation variations directly impact wheat growth stages such as emergence, tillering, jointing and booting, and maturity. Evaluating the impact of climate change on precipitation patterns during these critical growth stages is crucial for adapting climate change and ensuring global food security. In this study, projections of five General Circulation models (GCMs) under two shared socioeconomic pathways (SSPs) were used to predict the changing characteristics of precipitation during four main growth stages of wheat in the rainfed region of the Pothwar Plateau, Pakistan. Historical datasets of daily precipitation at six weather stations were analyzed to check the past changes in the precipitation patterns. During the baseline period (1985–2014), the annual average precipitation decreased at a rate of −9.75 mm/decade, while the amount of precipitation during the rabi season (wheat-growing season) decreased at a rate of −20.47 mm/decade. An increase in the precipitation was found during the fourth (flowering) stage of crop growth, while the first three stages experienced a decrease in the precipitation amount. The multimodal ensembled data, under the SSP2-4.5 scenario, revealed a significant decline (at the rate of −16.63 mm/decade) in the future annual precipitation. However, it is projected that, under SSP2-4.5, there may be a slight increase (4.03 mm/decade) in the total precipitation amount during the future rabi season. Under the SSP5-8.5 scenario, average annual precipitation exhibited a slightly increasing trend, increasing by 1.0 mm/decade. However, during the rabi season, there was a possibility of a decrease in precipitation amount, with a rate of 11.64 mm/decade. It is also expected that the precipitation amount may vary significantly during the crown root initiation, jointing and booting, and flowering stages in the near future. These results provide a framework for the planning of wheat production in the Pothwar region of Pakistan, taking into account the potential impact of shifting weather patterns, particularly in terms of uneven precipitation.

Personality and Transition From Mild Cognitive Impairment to Normal Cognition vs Dementia

ObjectivesMild cognitive impairment (MCI) is a critical stage preceding incident dementia, but not all individuals with MCI progress to dementia and some revert to normal cognition. This study examined whether personality is associated with the probability of transition from MCI to normal cognition or dementia. DesignLongitudinal observational study. Setting and ParticipantsOlder adults with MCI from the Health and Retirement Study (N = 1608, 56% female, mean age = 72.29, SD = 9.91). Personality traits; cognitive status; and demographic (age, sex, education, race, and ethnicity), clinical (diabetes, hypertension), behavioral (smoking, physical activity), psychological (depressive symptoms), and genetic (apolipoprotein E ε4) covariates were obtained in 2006/2008. Follow-up data on cognitive status were collected every 2 years up to the 2020 wave. MethodsCox regression analyses tested the association between personality and reversion from MCI to normal cognition and progression to dementia, controlling for demographic, clinical, behavioral, psychological, and genetic covariates. ResultsControlling for demographic factors, lower neuroticism and higher openness and conscientiousness were associated with a higher likelihood of reversion from MCI to normal cognition and a lower risk of progression to dementia over time. Higher agreeableness was related to a lower risk of progression to dementia. Clinical, behavioral, psychological, and genetic factors partially accounted for these associations. There was little evidence that demographic, genetic factors, or baseline cognition moderated these associations. Conclusions and ImplicationsPersonality traits can help identify individuals who are more likely to revert from MCI and not progress to dementia. These findings suggest that even during mild impairment, personality may modulate dementia risk and thus inform targeted interventions.

Individual and joint associations of air pollutants exposure with semen quality: A retrospective longitudinal study in Wenzhou, China.

The impact of air pollution on semen quality has been confirmed, yet the joint effect remains unclear. We evaluate the individual and joint associations of particulate (PM2.5 and PM10) and gaseous pollutants (NO2, SO2, O3 and CO) with semen quality. We included 5,114 men in this study from 2014 to 2022. The individual and joint associations were measured by multiple linear regression models. Sperm motility and semen volume were inversely associated with pollutant concentrations during every stage of sperm development, especially at lag days 0-9 and 10-14 (all P < 0.05). Stratified analyses showed that the study pollutants (except CO) had a positive effect on semen concentration during the stage of sperm development, especially in spring and autumn, while a decreased total sperm number was associated with CO (all P < 0.05). However, joint associations of particulate and gaseous pollutants with semen quality parameters were not statistically significant (all P > 0.05). During all stages of sperm development, particulate and gaseous pollutants had individual negative impacts on spermmotility andsemen volume, and these impacts were less pronounced in spring and autumn. Our findings highlight the importance and necessity of reducing the exposure to pollutants especially in the critical stage of sperm development to improve semen quality.

Single-cell profiling reveals altered immune landscape and impaired NK cell function in gastric cancer liver metastasis.

Gastric cancer (GC) is a substantial global health concern, and the development of liver metastasis (LM) in GC represents a critical stage linked to unfavorable patient prognoses. In this study, we employed single-cell RNA sequencing (scRNA-seq) to investigate the immune landscape of GC liver metastasis, revealing several immuno-suppressive components within the tumor immune microenvironment (TIM). Our findings unveiled an increased presence of cancer-associated fibroblasts (CAFs), myeloid-derived suppressor cell (MDSC)-like macrophages, tumor-associated macrophage (TAM)-like macrophages, and naive T cells, while conventional dendritic cells (cDCs) and effector CD8 T cells declined in LM. Additionally, we identified two distinct natural killer (NK) cell clusters exhibiting differential cytotoxicity-related gene expression, with cytotoxic NK cells notably reduced in LM. Strikingly, TGFβ was identified as an inducer of NK cell dysfunction, potentially contributing to immune evasion and tumor metastasis. In preclinical LM models, the combined approach of inhibiting TGFβ and transferring NK cells exhibited a synergistic impact, resulting in a significant reduction in liver metastasis. This work highlights the importance of understanding the complex immune dynamics within GC liver metastasis and presents a promising strategy combining TGFβ inhibition and NK-based immunotherapy to improve patient outcomes.

Estrogen receptor Esr1 induces early ovarian differentiation in Trachemys scripta

This study aims to explore the roles of three estrogen receptors (Esr1, Esr2, and Gper1) in early differentiation of embryonic gonads of Trachemys scripta. The expression characteristics of the receptor genes were studied first. The Esr1, Esr2, and Gper1 agonists PPT, WAY 200070, and G-1 were respectively injected into the embryos at the male-producing temperature (MPT) before initiation of gonadal differentiation. The sex reversal of the treated embryonic gonads was analyzed in terms of morphological structure of gonads, distribution pattern of germ cells, and expression of key genes and proteins involved in sex differentiation. The expression level of esr1 during the critical stage of sex differentiation was higher than those of esr2 and gper1 (very low expression) and was particularly high in the gonads at the female-producing temperature (FPT). After treatment with PPT, the MPT gonads presented obviously feminized morphology and structure, with the germ cells exhibiting a female distribution pattern. Furthermore, the mRNA expression levels of the key genes (dmrt1, amh, and sox9) for male differentiation were down-regulated significantly, while those of the key genes (foxl2 and cyp19a1) for female differentiation were up-regulated observably. The fluorescent signals of Amh and Sox9 expression almost disappeared, while Foxl2 and Arom were activated to express abundantly, which fully demonstrated the sex reversal of the gonads from male to female (sex reversal rate: 70.27%). However, the MPT gonads treated with WAY 200070 and G-1 still differentiated into testes, and the expression patterns of the key genes and proteins were similar to those in male gonads. The above results demonstrate that activation of Esr1 alone can fully initiate the early female differentiation process of gonads, suggesting that estrogen may induce early ovarian differentiation via Esr1 in Trachemys scripta. The findings provide a basis for further revealing the mechanisms of estrogen regulation in sex determination and differentiation of turtles.

Cluster Frontline Demonstration: An Effective Technology Dissemination Approach for Maximization of Productivity and Profitability of Chickpea (Cicer arietinum L.)

Background: Chickpea (Cicer arietinum L.) is a premier legume crop of Fabaceae family. It is also known as gram and Kabuli chana. It is one of the major rabi season pulse crop of the Ratlam district. The main objective of this study is the enhance production and productivity of chickpea through CFLDs with latest and specific technologies viz- large seeded high yielding varieties and resistance to fusarium wilt (RVG 202) chickpea variety under best package of practices. The major problem of ratlam district is productivity of chickpea is very low because of non-adoption of latest intervention by the farmer’s like use wilt resistant variety, imbalance use of plant nutrient, water stress at critical stage, infestation of weeds and incidence of pest. Methods: The present study was carried out by the Krishi Vigyan Kendra, Jaora, Ratlam District (M.P) during rabi season. Total 110 demonstration in farmer’s field of ratlam district during two years i.e., from rabi, 2020-21, rabi 2021-22 on integrated crop management (ICM). Front line demonstration on chickpea were organized five cluster of ratlam district. The demonstration intervention technology is improved variety (RVG-202), Optimum seed rate 80 kg/ha, properly seed treatment, crop nutrient management RDF as per STV, water management at critical stages, weed management and application of IDM module for the management of disease. Result: The results of study show a positive impact onfarming community due to the significant enhancement in crop yield greater than farmer. Results of the study revealed that the interventions increase demonstration field seed yield of chickpea by 30.76 and 32.71% over the farmers' field respectively, both the years. The average intervention technology gap (3.04 q/ha) extension gap 4.08 q/ha) and Technology index 15.22% suggested further improvement in the extension activities. The annual average benefit: cost ratio was higher (2.43 and 2.52) of the demonstrated plot compare to farmers plot (1.95 and 1.97), respectively. The similar trend was observed in terms of gross and net income returns which was demonstration plot is Rs 94589 Rs 67385 and under farmer's plot it was Rs 72783 and Rs. 49283 respectively.

Ningxiang Pig-Derived Parabacteroides distasonis HNAU0205 Alleviates ETEC-Induced Intestinal Apoptosis, Oxidative Damage, and Inflammation in Piglets.

Weaning is a critical stage in the growth and development of piglets, often inducing stress reactions. This study aims to investigate the effects of Parabacteroides distasonis (PBd) derived from Ningxiang pigs on growth performance, intestinal apoptosis, oxidative damage, and inflammation in ETEC-challenged weaned piglets. A total of 22 Duroc × Landrace × Yorkshire (DLY) piglets, 24 days old with similar body weights, were randomly divided into three groups: Control (n = 7), ETEC (n = 7), and PBd + ETEC (n = 8). The results show that, compared to the Control group, ETEC challenge led to decreased growth performance, reduced villus height in the duodenum and jejunum, increased crypt depth in the duodenum, a decreased villus-height-to-crypt-depth ratio, increased expression of apoptosis-related genes (Caspase-8 and Caspase-9), increased expression of oxidative damage-related genes (Nrf2, GSH-PX, mTOR, and Beclin1), increased expression of inflammation-related genes (Myd88, P65, TNF-α, and IL-6), and reduced the contents of SCFAs in the colonic chyme (acetate, propionate, butyrate, valerate, and total SCFAs). Compared to the ETEC group, the PBd + ETEC group alleviated the reduction in growth performance, mitigated intestinal morphological damage, and reduced the expression of the aforementioned apoptosis, oxidative damage, and inflammation-related genes with the increase in SCFAs. In conclusion, PBd derived from Ningxiang pigs effectively reduces ETEC-induced intestinal damage in weaned piglets, improves intestinal health, and increases the content of SCFAs in the colonic chyme, thereby enhancing growth performance.

Effects of Design Factors and Multi-Stage Environmental Factors on Hydrological Performance of Subtropical Green Roofs

Environmental and design factors determine the stormwater management capacity of green roofs; however, the design and environmental factors that impact their hydrological performance in subtropical humid regions are poorly understood. In particular, meteorological factors have received little attention. Meteorological factors vary greatly at different stages of a rainfall event (e.g., during the rainfall and outflow). Therefore, the impact of meteorological factors at different stages on hydrological performance should be considered separately to obtain a more accurate picture of their effects on hydrological performance. In this study, experimental green roofs were established based on four substrate types and two depths. For the first time, this study systematically explored the effects of design factors for the substrate (type and depth) and multi-stage environmental factors on the hydrological performance of green roofs. Environmental factors, including meteorological factors, from three critical stages (before and during a rainfall event and during the outflow), and rainfall characteristics (e.g., rainfall depth and rainfall duration) were incorporated to determine the variation in hydrological performance. The effects of multi-stage environmental factors on retention and peak reduction were analyzed, with a ranking of each factor’s relative importance. Environmental factors played a leading role in determining hydrological performance. However, the impact of multi-stage environmental factors was not as important as that of rainfall depth and antecedent volumetric water content. Differences in hydrological performance were compared across combinations of design factors. No significant differences were observed across substrate types and depths. However, potential interactive effects might exist, though these were not significant compared to environmental factors (e.g., rainfall depth and rainfall duration). These results confirmed that the meteorological factors in the different event-related stages significantly impacted the hydrological performance. Quantifying the effects of design and environmental factors is critical for hydrological performance evaluation. The results provided a broader perspective on understanding influence mechanisms of hydrological performance and highlighted the impact of microclimates on hydrological performance.

A review on prospect of wheat in Nigeria: Technological Advancement in Focus

The main issue affecting domestic wheat production in Nigeria is environmental incompatibility— the fact that wheat, being a temperate crop, requires cold climates during the growing season to thrive especially during the critical developmental stage between tillering and grain filling. This has limited the wheat growing season in Nigeria, to the cool harmattan period starting from November to March, and the wheat growing areas in Nigeria, along latitude 10°N to 14°N. Unfortunately, the harmattan period itself is also challenged by the absence of a rainy season, which typically starts after the period from April to September with unfavourable high temperature and humidity. Nigerian government policies over the years have centred on accelerating primary production (farming) instead of focusing on addressing the main issues, through research and development of cultivars that will be adaptable in Nigeria’s heat-stressed growing environment, build more irrigation areas along the harmattan latitude, strengthen extension services to ensure farmers adherence to Good Agronomic Practices (GAPs) and ease farmers access to market for fair prices. As a result, the national average ton per hectare output is abysmally 1.3 MT, prepared irrigation area is less than 10% of planned area and a near-complete disconnect between farmers and the off-taking flour milling industry, who are currently fully reliant on imported wheat. The peculiar situation is like in other tropical countries like Egypt, Ethiopia and the warm and humid Bangladesh. The paper recommended the adoption of molecular breeding technologies to strengthen the breeding processes and shorten the seeds generation time.

Cognitive structures among middle school students

The current research aims to identify 1 - the maladaptive cognitive structures of middle school students. 2,Statistically significant differences in non-adaptive cognitive structures according to the gender variable (males - females) . Statistically significant differences in non-adaptive cognitive structures according to the specialization variable (scientific Humanitarian). To achieve the objectives of the research, the researcher prepared a measure of maladaptive cognitive structures consisting of: items. The researcher applied the tool to the research sample that was chosen randomly and consisted of(40) male and female students from the preparatory stage(300). The results of the research showed that the students of the preparatory stage Preparatory school and their critical age stage, which is characterized by rapid physical growth and changes Due to the abundance of derivatives around them, they appeared to have non-adaptive cognitive structures. Although male and female preparatory school students received the same and similar experiences, no difference appeared between them in their cognitive structures Non-adaptive, and there appeared a difference in specialization in favor of scientific specialization.

A unified approach for breast cancer discrimination using metasurface-based microwave technology

Multifocal (MF) and multicentric (MC) breast cancers are more likely to be aggressive than unifocal (UF) breast tumors, and they are linked to high recurrence probability, lymph node metastases, and low survival rates. Metastasis is the process through which cancer cells spread to different body areas. Although the longevity of patients with metastatic breast cancer is high, it is restricted by the growth of brain metastases. Medical imaging techniques have inherent limits. Hence, a precise and sensitive substitution is required. Because microwave imaging is portable, non-ionizing, and affordable, it has become a viable method for the detection of breast cancer. As far as we know, this is the first research aiming at discriminating MF and MC breast cancers from UF ones. This proposal presents a 2×2\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$2\ imes 2$$\\end{document} planar metasurface-based array antenna in the Industrial Scientific Medical frequency band at 2.4 GHz. The proposed array configuration significantly enhanced the gain to 4 dBi rather than a single element at 50 Ω. The geometric arrangement of the four antenna elements is optimized to discriminate the critical stage of breast cancers (UF, MF, or MC). As the proposed structure does not surround the breast, it contributes to a higher degree of comfort than the conventional antenna configurations. The magnitude and phase of S-parameters of the backscattered signals are analyzed in this research.

Assessment of gnostic and stereognostic functions in patients with liver cirrhosis: A comparative study with healthy controls.

Individuals diagnosed with liver cirrhosis typically experience a variety of symptoms. Decompensation, a critical stage in the disease's progression, is characterized by the emergence of prominent clinical signs. These signs typically include ascites, bleeding tendencies, hepatic encephalopathy, and jaundice. Furthermore, it is noteworthy that regions in the sensorimotor cortex responsible for practical and gnostic functions are closely situated within the parieto-occipital part of the cortex. Liver cirrhosis may also have an impact on this aspect of human motor function. The main objective of the study is to compare the gnostic function and stereognostic function in individuals with liver cirrhosis and those in a healthy population. The patients included in our registry, known as RH7, were enrolled in our study. The first group consisted of 74 liver cirrhosis patients (including 25women and 49men). The control group consisted of a 63healthy population (including 23women and 40 and men). Both groups underwent both the Petrie and kinaesthesia tests. The results of the Petrie test, which compared healthy participants with those with liver cirrhosis, indicate that the healthy population achieved a significant difference in both right and left upper limb compared to those with liver cirrhosis patients (p< 0.05). The healthy population showed a significant difference compared to liver cirrhosis patients in the kinesthesia test (p< 0.05), except for the second attempt with the left upper limb (p= 0.267). According to the LFI, there was no significant difference in either upper limb during both the initial and second attempts of Petrie test (p> 0.05). Patients with liver cirrhosis exhibited significantly poorer gnostic functions compared to the healthy population. This condition also leads to notable impairments in motor functions, affecting both the precision and coordination of movements. Despite these deficits, frailty alone does not appear to be an indicator of worsened gnostic or stereognostic functions. Therefore, while liver cirrhosis has a clear negative impact on motor and cognitive abilities, the presence of frailty does not necessarily exacerbate these specific cognitive deficits. This distinction is crucial for clinical assessments and interventions targeting motor and cognitive rehabilitation in patients with liver cirrhosis.

Reasons for Discharge in a National Network of Early Psychosis Intervention Programs.

Discharge from early psychosis intervention is a critical stage of treatment that may occur for a variety of reasons. This study characterizes reasons for discharge among participants in early psychosis intervention programs participating in the Early Psychosis Intervention Network (EPINET) which comprises >100 programs in the United Statesorganized under 8 academic hubs. We analyzed 1787 discharges, focusing on program completion, unilateral termination by the client/family, and lost contact with the client/family. We performed exploratory analyses of demographic, clinical, and functional predictors of discharge reason. Variables predictive of discharge type were included in multilevel logistic regressions, allowing for the estimation of predictors of discharge reason and variability in rates by program and hub. An estimated 20%-30% of enrolled patients completed the program. Program completion rates were higher among participants who were older on admission, had lower negative symptoms severity, spent more time in education, employment, or training, and who were covered by private insurance (a close proxy for socioeconomic status). Programs were more likely to lose contact with male participants, Black participants, and participants who were never covered by private insurance. After accounting for patient-level factors, there was substantial program-level variation in all 3 discharge outcomes, and hub-level variability in the proportion of participants who completed the program. The impact of race on program completion varied substantially by program. Participants were discharged from early psychosis intervention services for diverse reasons, some of which were associated with sociocultural factors. Disengagement is a widespread problem affecting all hubs.

Evaluating the Influence of Different Agronomic Strategies on the Growth and Development of Maize (Zea mays L.) Grown in Rice Fallows of Northern Telangana Zone

Aims: To study the changes in plant height, dry matter production, leaf area and plant population under different tillage practices, irrigation and nitrogen levels in rice fallow maize. Study Design: Split- split plot design. Place and Duration of Study: Regional Agricultural Research Station farm, Polasa, Jagtial during rabi 2022-23 and 2023-24. Methodology: The experiment was laid out in split- split plot design with twelve treatment combinations that includes 2 main plot, 3 sub plot and 2 sub-sub plot treatments which are replicated thrice. The treatments are as follows: Main plots: T1- Zero tillage, T2- Conventional tillage (tillage with cultivator twice fb rotovator twice); Sub plots: I1- Irrigation at 60% ASM, I2- Irrigation at 40% ASM and I3- Irrigation at six critical stages; and Sub-sub plot treatments: N1- 100% RDN (240 kg ha-1) and N2- 120% RDN (288 kg ha-1). Results: Results indicated that highest mean plant height was recorded in conventional tillage (65.8, 204.4 &amp; 210.9 cm) and in N2 treatment (64.6, 201.3 &amp; 207.6 cm) during sixth leaf, silking and physiological maturity respectively. Irrigations showed non-significant effect during sixth leaf and during other two stages I3 treatment has recorded higher plant height (200.1 &amp; 206.6 cm). Similar results were obtained in case of leaf area. The mean dry weight was also higher in conventional tillage (17915 kg ha-1), I3 treatment (16789 kg ha-1) and N2 (16418 kg ha-1). The initial plant population was higher in conventional tillage (7.2 plants m-2) than that of zero tillage and irrigation &amp; nitrogen levels has no effect on population. Conclusion: All the growth parameters were significantly affected by tillage, irrigation and nitrogen levels at all the stages except the influence of irrigation on plant height at sixth leaf stage. Plant population was significantly affected by tillage but non-significant effect was recorded by irrigation an nitrogen levels. Interaction was found between irrigation and nitrogen levels in-case of dry matter production.

Development of non-invasive diagnosis based on FTIR spectroscopy

Numerous illnesses progress silently, often reaching a critical stage by the time symptoms appear, making medical intervention difficult. While there exist sophisticated clinical techniques for precise disease detection, they are often invasive procedure and as a rule of thumb is used only with definite symptomatic cases. In addition, the extreme clinical costs prevent a large population from taking advantage of contemporary medical facilities. A non-invasive, economically feasible screening method that detects diseases even in their pre-symptomatic stages may overcome many critical challenges in health and medicine. Utilizing vibrational spectroscopy to identify volatile metabolites offers promise as such a non-invasive, cost-effective diagnostic tool. The article outlines the potential of vibrational spectroscopy for non-invasive diagnostics and proposes a method for its clinical implementation.

A taste of youth: Seasonal changes in the diet of immature white sharks in eastern Australia

White sharks (Carcharodon carcharias) play a crucial ecological role, shaping ecosystems through direct predation and risk effects. On the east coast of Australia, immature white sharks are broadly distributed, inhabiting a wide range of habitats and ecosystems from temperate Tasmania to tropical North Queensland. Using stable isotopes and fatty acids of muscle and plasma, we examined the diet and habitat use of 136 immature white sharks (152–388 cm total length) captured on SMART drumlines on the East Australian coast. This facilitated the temporal assessment of white shark trophic ecology from a few weeks to approximately a year. Biochemistry of muscle samples showed that white sharks predominantly feed on low trophic level prey from coastal environments. A seasonal shift in diet was evident, with the increasing proportions of essential fatty acids in muscle tissues during spring and summer suggesting a greater consumption of high-nutrition preys during those months compared to autumn and winter. By combining stable isotope and fatty acid analysis, we gain a comprehensive understanding of immature white shark diet in eastern Australia. Our results confirm that white sharks are generalist predators that exhibit seasonal shifts in their diet. Their high use of coastal habitats reinforces the importance of these areas for foraging, which is crucial for growth and development during this critical life stage.

Research on seismic performance of reinforced concrete structures reinforced with CFRP plates

In the modern construction industry, natural disasters such as earthquakes pose an increasingly prominent threat to reinforced concrete structures, which often lead to serious damage to the structures. Therefore, how to enhance the seismic performance of reinforced concrete structures has become an urgent problem to be solved in the field of construction. This study delves into the seismic performance of CFRP plates in strengthening reinforced concrete structures. Firstly, the material characteristics of CFRP panels were analyzed, including the mechanical and adhesive performance indicators of carbon fiber panels, and corresponding specimens were made. Subsequently, through specimen loading experiments, the performance of reinforced specimens and unreinforced specimens under load was compared. The experimental results show that prestressed CFRP plates can significantly increase the cracking load and enhance the seismic resistance of reinforced concrete structures. In addition, simulation tests were conducted using a finite element model. Through simulation testing, the load deflection curve of the specimen was obtained, revealing the influence of CFRP plates on beam stiffness. Especially in the critical stages of concrete cracking and yielding of tensile steel bars, carbon fiber board has a particularly significant effect on improving the stiffness of beams.

Empowering Smallholder Sorghum Farmers for Resilience: Lessons from a Community-Based Seed Multiplication Scheme in West Hararghe, Ethiopia

Sorghum is a vital crop for food security in Ethiopia. Sorghum landraces are particularly crucial in crop-livestock mixed farming, however, the extended growing periods (6-8 months) required for these landraces make the crop vulnerable to recurrent drought events associated with delayed rain, dry spells, and drought during critical stages. The landraces are usually planted in March or April depending on the onset of rainfall and harvested around November but often fail due to drought. In such situations, early-maturing improved varieties are an option for farmers but access to seeds of these improved varieties is a challenge. Unlike the landraces, the improved early maturing varieties are planted around the first weeks of July and harvested in November. The formal seed system multiplies only a limited amount of improved sorghum seed, which is rarely available to smallholder sorghum growers, mostly as part of a government package for targeted programs. Therefore, a community-based seed multiplication (CBSM) scheme was introduced to address seed shortages among smallholder sorghum farmers. After a successful experiment in 2015 aimed at enhancing seed multiplication by smallholder sorghum farmers, the process was further implemented on a larger scale using the CBSM scheme. Between 2016 and 2017, three CBSM farmer groups consisting of a total of 56 participants were established in three districts of West Hararghe, Ethiopia. Seeds of two early-maturing and drought-tolerant improved sorghum varieties (Dekeba and Melkam) were multiplied on a total area of 49.58 hectares, resulting in 215.6 tons of certified seeds. The study&amp;apos;s findings indicate that the CBSM scheme enhanced smallholder farmers&amp;apos; sorghum yields, incomes, and climate resilience by providing high-quality seeds, expanding access to improved seeds, improving crop quality, and empowering communities to manage seed distribution. Partnerships with local organizations and government agencies were vital for success, allowing the scheme to reach more farmers in different regions. The scheme proved successful for smallholder sorghum growers in Ethiopia&amp;apos;s dry lowlands, offering lessons applicable to similar challenges elsewhere, and promoting sustainable solutions for smallholder farmers.

A case of bilateral straatsma syndrome

Straatsma syndrome is characterized by a constellation of conditions including amblyopia, nystagmus, and myopia. We present the case of a 10-year-old boy who complained of involuntary back-and-forth eye movements and reduced vision since birth. His visual acuity was measured at 2/60 in both eyes. Examination revealed horizontal pendular nystagmus without ocular misalignment. Fundus examination showed myopic changes, including an anomalous optic disc with extensive myelinated nerve fibers extending from the optic disc along the superior and inferior arcades to the fovea. Axial length measurements were 28.34 mm and 27.96 mm in the right and left eyes, respectively. SD-OCT imaging confirmed thickening of the retinal nerve fiber layer. Treatment included cycloplegic refraction and occlusion therapy, with regular follow-ups every three months utilizing contact lenses with cycloplegic refraction. The etiology of retinal fiber myelination remains unclear; however, it is hypothesized that blurred retinal imaging during critical ocular development stages may lead to axial elongation and subsequent myopia, potentially delaying the development of the lamina cribrosa and facilitating myelination extension.