The rapid digitization of industries and the proliferation of connected devices have exponentially increased the surface area for cyber threats, making traditional cybersecurity methods increasingly inadequate. The paper explores the integration of advanced technologies to enhance threat detection capabilities in a dynamically evolving cyber landscape. This study emphasizes the critical role of machine learning (ML) and big data analytics in identifying, analyzing, and mitigating cyber threats in real time. By leveraging the massive volumes of data generated across networks, ML algorithms can detect anomalous behavior patterns and predict potential threats with high accuracy. Big data analytics further enhances this process by processing and analyzing data at unprecedented speeds, enabling swift identification and response to security breaches. The comprehensive approach outlined in this study addresses key challenges, including the complexity of modern cyber threats, the need for scalability in cybersecurity solutions, and the importance of minimizing false positives. Additionally, the research highlights the importance of continuous learning models that adapt to new and emerging threats, ensuring that the system remains resilient against sophisticated attacks. Case studies of successful implementations across various industries are examined to demonstrate the practical applications and benefits of this approach. The findings suggest that integrating ML and big data analytics in real-time threat detection systems significantly improves cybersecurity defenses, providing organizations with the tools to proactively counteract cyber threats. This approach is positioned as a vital strategy for organizations seeking to fortify their cybersecurity posture in an increasingly interconnected world, where the speed and accuracy of threat detection are paramount to safeguarding critical assets and maintaining trust. Keywords: Real-Time, Cybersecurity, Threat Detection, ML, Big Data Analytics.