ABSTRACT Background: One of the most common and significant issues associated with alcohol consumption is its consequences, and one of the organs most affected is the brain. Numerous chronic drinkers in their fifth and sixth decades have demonstrated cortical atrophy in radiological examinations; nevertheless, there is little study in the young age range. Aim: To assess the degree of cortical atrophy in young male adults with alcohol dependence compared to those who have no history of alcohol consumption and its correlation with the severity of alcohol dependence. Materials and Methods: This cross-sectional study included a purposive sampling of 30 patients aged 18–45 years, fulfilling the diagnostic criteria of alcohol-dependence syndrome, and having no prior history of brain damage-causing substances other than alcohol. An equal number of age- and sex-matched control subjects were taken who did not have any history of alcohol consumption. Computed tomography (CT) scans were done for both groups. Alcohol Use Disorders Identification Test C (AUDIT-C), Severity of Alcohol Dependence Questionnaire (SADQ), and Global Cortical Atrophy (GCA) scale were applied to measure alcohol dependence and its severity and the degree of cortical atrophy. Results: All 30 male patients who fulfilled the criteria of alcohol dependence showed significant cortical atrophy in CT scans as compared to control subjects. Out of the 30 alcohol-dependence patients, 4 had only frontal lobe atrophy, while 26 patients had diffuse cortical atrophy, among which 19 patients showed frontal lobe predominance. The degree of atrophy and the severity of alcohol dependency also showed a strong association. Conclusion: There is a persistent pattern of neuroradiological evidence of diffuse cortical atrophy with frontal predominance in young people having alcohol dependence with a mean total duration of alcohol consumption of around 21 ± 5.5 years as compared to those who have no history of alcohol consumption.
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