Test Criteria Research Articles

Umroh Service Information System at El-Fajr Palembang

This article explores the integration of web technology in managing prospective Umrah pilgrims at El-Fajr Tour and Travel Palembang. In response to the rapid evolution of communication technology, the study emphasizes the efficiency and effectiveness of web-based communication in connecting users across diverse locations. El-Fajr Palembang, founded in 2018, envisions becoming a trusted leader in providing Umrah packages and travel services. To streamline operations and enhance services, the study adopts the waterfall model for system development. The article presents the results and discussion, focusing on the system interface's design, illustrated by the main page. Black box testing validates the functionality of user and admin interfaces, ensuring that all proposed functions operate effectively. The testing criteria cover aspects such as menu display, login functionality, travel package registration, and administrative tasks, all validated. In conclusion, the study affirms the successful implementation of the computerized web-based system at El-Fajr Palembang, poised to enhance Umrah pilgrim registrations, activity schedules, and information dissemination. The system aligns with El-Fajr Palembang's vision to become a leading travel and tour company, demonstrating the potential of web technology in optimizing service delivery.

Lorenz Kaotik Devre Tabanlı Entropi Kaynağı ile Özgün Gerçek Rasgele Sayı Üretimi ve Ses Şifreleme Uygulaması

This paper introduces a methodology for generating secure cryptographic key bits from analog values obtained from the Lorenz chaotic circuit. The analog values are transferred from the chaotic circuit to the computer via an Analog Discovery-2 device and then post-processed by using a fixed-point number representation format and Von-Neumann corrector for the sampled values on the MATLAB program. By employing this method, the analog values are digitized and randomized as the main idea is to obtain secure and efficient statistically random bits. Furthermore, the generated random bits are utilized for secure audio transmission by demonstrating a practical application of the proposed methodology. In addition to the classical randomness test criteria, and NIST 800.22 statistical test suite, the throughput bit stream is also subjected to Chi-square and FIPS 140-1 tests to further evaluate its effectiveness. The results of these comprehensive tests confirm the successful performance of the proposed system in generating statistically random bits and its secure audio encryption system. The utilization of the Lorenz chaotic circuit as an entropy source in generating true random bits for secure audio transmission applications showcases the potential of the proposed system.

P346 Assessing Brain Morphology in Functional Gastrointestinal and Inflammatory Bowel Disorders Using Functional Magnetic Resonance Imaging (fMRI)

Abstract Background Functional gastrointestinal disorders (FGIDs) and non-specific inflammatory bowel diseases (IBD) are increasingly common in young adults. Studies have shown abnormal interhemispheric interactions in FGIDs and altered Default Mode Network (DMN) connectivity in brain regions linked to gastric sensations and emotional regulation. This study explores these neural mechanisms in FGIDs and IBDs, focusing on chronic visceral pain and its association with DMN reorganization. Methods The study included patients with functional dyspepsia (FD), N=18; irritable bowel syndrome (IBS), N=20 and IBD, N=18 alongside a control group of 18 healthy volunteers. Selection criteria included the Rome III Criteria for FGIDs and various diagnostic tests for IBDs. MRI scans were conducted using a 3T Achieva TX Scanner, applying standard T1 and T2 sequences without contrast agents. Functional imaging utilized T2 Gradient Echo-Planar Imaging. Results DMN analysis showed no anterior-posterior split. Significant differences were observed in the IBD group compared to controls, particularly in the left superior frontal gyrus. When comparing all patient groups with controls, increased DMN connectivity was noted in the left cingulum and supplementary motor area. These areas were also significant when comparing only FGIDs patients with controls, indicating altered DMN connectivity in these disorders. Please see: Figure 1 and Table 1. Conclusion The study highlights differences in DMNs between patient and control groups, especially in the left superior frontal gyrus, left cingulum, and left supplementary motor area. All disease groups showed variations from controls in the DMN pattern within the left cingulum. Significant differences in the DMN of the supplementary motor area were observed in functional gastric disease groups compared to controls. These findings suggest a link between brain areas involved in sensorimotor processes and symptoms of FD and IBS, providing insights into the neural basis of these conditions. Despite varied changes, common features differentiating the entire study group from healthy controls were identified. This condensed version focuses on the key aspects of your original text, ensuring that the main findings and methodology are clearly presented within the character limit.

Penerapan Teknologi Quick Response Code dan First in First out Berbasis Web Pada Sistem Pemesanan

Problems that occur from the order side are errors in recording or taking customer orders. This can result in incorrect order delivery or customers who are dissatisfied with the service. If the booking system is inefficient, the booking may take too long to process. The implementation of ordering and payment systems using Quick Response Code (QR Code) technology and First in First Out (FIFO) methods has delivered significant results in improving operational efficiency and customer experience. The use of QR Codes allows customers to easily scan codes on menus or products they order using their mobile devices. This reduces the time it takes to order food or products and avoids human error in ordering. Based on the results of the recapitulation of the 6 test criteria that have been carried out, the results of the number of answers from respondents are obtained which have a value of 100% in accordance with testing system functionality using blackbox testing. The results of processing respondent response data based on ISO 25010 aspects of Performance Efficiency, Operability Aspects, and Functional Efficiency Aspects obtained a total score of 85.47%. Based on this, the ISO 25010 prototype is very good for ordering systems using Web-Based Quick Response Code (QR Code) and First in First out (FIFO) Technology.

High‐velocity impact behavior of nonwoven mats and unidirectional prepreg hemp and flax fibers reinforced hybrid biocomposites

AbstractHigh specific impact strength and stiffness are demanded in various applications, leading to the widespread utilization of fiber‐reinforced polymers. Synthetic fiber‐reinforced polymers have been used to meet these engineering requirements. However, the current popularity of biocomposites arises from their environmental friendliness, ease of availability, and affordability, making them a favored alternative to synthetic‐based fiber‐reinforced polymers. An assessment must be conducted to determine whether biocomposites can replace their synthetic fiber counterparts, necessitating a thorough investigation into their impact behavior. This study aims to unveil the impact performance of hybrid biocomposites made from unidirectional prepregs comprising flax/polypropylene fibers and nonwoven mats composed of hemp/polypropylene fibers. The impact performance of hybrid biocomposites has also been studied concerning the number of layers and stacking sequence. Eight different designs of biocomposite plates are manufactured through compression molding and subsequently subjected to high‐velocity impact tests. Additionally, numerical simulation using the FEM is utilized to model and analyze the impact behavior of one specimen. The test results indicate that each design possesses unique characteristics and impact behaviors differ.Highlights Adding prepreg significantly improved mechanical performance in the biocomposites. Performance enhancement varies depending on the stacking sequence. Adding multiple layers of UD prepregs enhances mat impact performance. Numerical simulations validate the Tsai‐Wu criterion for impact testing.

Development of Characteristic Indicators for Identifying Talented Youth Football in Meizhou, Guangdong

Background and Aim: Sport is important to the people and the country in terms of improving the quality of life promoting health, cultivating sportsmanship, making pride, and economic development of the country. The development of athletes' potential and elevating the standard of the national sport requires knowledge and processes. The research aims to develop the indicators of special abilities of youth football players and create normal criteria for the indicators of talent of youth football players classified by playing positions. Materials and Methods: The Population and sample are 20 teams, 320 male youth football players in Meizhou city, and high-potential youth football players aged between 16-18 years. The research process is as follows: 1) study relevant documents, textbooks, research papers, and literature to determine competency indicators; 2) present the draft indicator prototype to experts and experts for review to consider its validity; 3) collect test data; 4) create normal criteria and scoring criteria of the talent indicator test for youth football players; 5) connoisseurship Talented Indicator of special abilities of youth football players by 11 experts. Using descriptive statistics such as percentages, arithmetic mean, and standard deviation for analyzing the data. Results: The results obtained talent indicators of special abilities of youth football players and normal criteria for talent indicators of special abilities of youth football players in 4 areas: 1. Physiology and physical fitness; 2. Body composition; 3. Football skills; and 4. Cognitive function, which can be applied in examining youth football athletes with outstanding abilities or in selecting youth football athletes to represent the country in international competitions including used to check the strengths and shortcomings of athletes. Conclusion: This study has developed normal criteria for indicators of special abilities of youth football players using the Normalized T-score method by setting the score criteria into 5 levels that correspond to the T-score and percentile. However, the normal criteria obtained from this research study can be used to evaluate potential and genius in youth football. This will give you information about football players' youth with special abilities or important characteristics that are likely to be successful in sports at the highest level internationally in the future.

Living with trimethylaminuria and body and breath malodour: personal perspectives

BackgroundMany people suffer from body and breath malodour syndromes. One of these is trimethylaminuria, a condition characterized by excretion in breath and bodily fluids of trimethylamine, a volatile and odorous chemical that has the smell of rotting fish. Trimethylaminuria can be primary, due to mutations in the gene encoding flavin-containing monooxygenase 3, or secondary, due to various causes. To gain a better understanding of problems faced by United Kingdom residents affected by body and breath malodour conditions, we conducted a survey.MethodsTwo anonymous online surveys, one for adults and one for parents/guardians of affected children, were conducted using the Opinio platform. Participants were invited via a trimethylaminuria advisory website. Questions were a mix of dropdown, checkbox and open-ended responses. Forty-four adults and three parents/guardians participated. The dropdown and checkbox responses were analysed using the Opinio platform.ResultsAll participants reported symptoms of body/breath odour. However, not all answered every question. Twenty-three respondents experienced difficulties in being offered a diagnostic test for trimethylaminuria. Problems encountered included lack of awareness of the disorder by medical professionals and reluctance to recognise symptoms. Of those tested, 52% were diagnosed with trimethylaminuria. The main problems associated with living with body/breath malodours were bullying, harassment and ostracism in either the workplace (90%) or in social settings (88%). All respondents thought their condition had disadvantaged them in their daily lives. Open-ended responses included loss of confidence, stress, exclusion, isolation, loneliness, depression and suicidal thoughts. Respondents thought their lives could be improved by greater awareness and understanding of malodour conditions by medical professionals, employers and the general public, and appreciation that the malodour was due to a medical condition and not their fault.ConclusionsBreath and body malodour conditions can cause immense hardship and distress, both mentally and socially, having devastating effects on quality of life. It would be advantageous to establish a standardised pathway from primary care to a specialist unit with access to a robust and reliable test and diagnostic criteria. There is a need to recognise malodour disorders as a disability, giving affected individuals the same rights as those with currently recognised disabilities.

Phenotype analysis of families with TP53 germline variants at the Center for Familial Breast and Ovarian Cancer, Cologne.

Tumor protein p53 (TP53) pathogenic variant (PV) carriers are identified during genetic testing for hereditary causes of cancer. PVs in TP53 are associated with the Li-Fraumeni syndrome (LFS), and thus, surveillance and preventive measures are important for TP53 PV carriers. However, the penetrance of TP53 PVs can be low if the Chompret criteria are not fulfilled. In this study, we compared the phenotypic characteristics of families that did and did not fulfill the LFS criteria according to Chompret. The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) database was used to identify index patients with a likely pathogenic/pathogenic TP53 variant and their family members. The study investigated the type of variant, pedigree, age of onset, number of primary tumors, and histological type of BC. TP53 PV were present in the index cases of 35 families, 57% (20/35) of which fulfilled the Chompret criteria. The median age of onset at first BC diagnosis was lower in families that fulfilled the Chompret criteria compared to those who did not. Four of all diseased individuals were minors (4%; 4/105) when malignancy was first diagnosed. Sarcomas and brain tumors occurred in 10% (10/105) and in 7% (7/105) of all diseased persons, respectively. BC was the most frequently occurring first tumor (60%; 62/105) and additional malignancy (45%; 20/44) in this cohort. Subsequent malignancies developed in 31% (20/65) of the individuals who fulfilled the Chompret criteria compared with 15% (6/40) of those who did not. The tumor spectrum and age of onset found in this study showed that tumors other than BC had low disease penetrance in TP53 PV carriers identified using the GC-HBOC criteria for genetic testing.

Estimation of epidemiological cut-off values for eight antibiotics used for treatment of bovine mastitis caused by Streptococcus uberis and Streptococcus dysgalactiae subsp. dysgalactiae

Interpretive criteria for antimicrobial susceptibility testing are lacking for most antimicrobials used for bovine streptococcal mastitis. The objectives of this study were to determine (tentative) epidemiological cut-off ((T)ECOFF) values for clinically relevant antibiotics used for treatment of bovine mastitis, and to estimate the proportion of acquired resistance (non-wild-types) in Streptococcus dysgalactiae subsp. dysgalactiae and Streptococcus uberis. A total of 255 S. uberis and 231 S. dysgalactiae subsp. dysgalactiae isolates were obtained in Denmark and Norway from bovine mastitis. The isolates were tested for susceptibility to 10 antibiotics using broth microdilution. In accordance with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standard operating procedure, additional published MIC distributions were included for the estimation of ECOFFs for cloxacillin, cephapirin, lincomycin and tylosin, and TECOFFs for amoxicillin, benzylpenicillin, cephapirin and oxytetracycline. The proportion of non-wild-type (NWT) isolates for the beta-lactams was significantly higher in the Danish S. uberis (45–55%) compared to the Norwegian isolates (10–13%). For oxytetracycline, the proportion of NWT was significantly higher in the Danish isolates, both for S. uberis (28% vs. 3%) and S. dysgalactiae (22% vs. 0%). A bridging study testing in parallel MICs in a subset of isolates (n = 83) with the CLSI-specified and the EUCAST-specified broths showed excellent correlation between the MICs obtained with the two methods. The new ECOFFs and TECOFFs proposed in this study can be used for surveillance of antimicrobial resistance, and - for antimicrobials licensed for streptococcal bovine mastitis - as surrogate clinical breakpoints for predicting their clinical efficacy for this indication.

Relationship between Volitional and Non-Volitional Quadriceps Muscle Endurance in Patients with Chronic Obstructive Pulmonary Disease.

Volitional assessment of quadriceps muscle endurance is clinically relevant in patients with chronic obstructive pulmonary disease (COPD). However, studies that determine the construct validity of volitional tests by comparing them to non-volitional measures are lacking. Therefore, the aim of the current study is to evaluate the correlation between volitional and non-volitional quadriceps muscle endurance in patients with COPD. Quadriceps muscle endurance was evaluated in twenty-six patients with COPD. A volitional isometric and a volitional isokinetic protocol were performed on a computerised dynamometer to determine the isometric time and isokinetic work fatigue index, respectively. Non-volitional assessment of quadriceps muscle endurance was evaluated using repetitive electrical stimulations to establish the isometric muscle force decline. Sixteen patients (61 ± 8 years, 63% male, FEV1 47 (32-53)%) performed all three quadriceps endurance tests conforming to pre-defined test criteria. Both volitional isometric time and isokinetic work fatigue index did not significantly correlate with non-volitional muscle force decline (both p > 0.05). There was a strong correlation between volitional isometric time and isokinetic work fatigue index (rho = -0.716, p = 0.002). To conclude, this study suggests that volitional measures evaluate partly different aspects of quadriceps muscle endurance compared to non-volitional measures. Accordingly, these outcome measures cannot be used interchangeably.

Determinasi Literasi Keuangan, Inklusi Keuangan dan Literasi Digital terhadap Kinerja Usaha Mikro Kecil Menengah: Studi pada UMKM di Kabupaten Sumenep


 This research aims to examine the influence of financial literacy, financial inclusion and digital literacy on the performance of micro, small and medium enterprises (MSMEs). This research is quantitative research. The population in this study were all MSMEs in Sumenep Regency using a purposive sampling technique. The sample included in the test criteria was 108 respondents. Test results using multiple linear regression show that financial literacy and digital literacy have an effect on MSME performance, while financial inclusion has no effect on MSME performance.
 Keyword: financial literacy, financial inclusion, digital literacy, MSMEs

Sleepy Kids: are the current diagnostic criteria for multiple sleep latency tests enough?

Excessive daytime sleepiness (EDS) is common in childhood and is currently quantified using adult criteria on a multiple sleep latency test (MSLT). This study aimed to describe paediatric MSLT results, particularly focussing on a previously proposed alternative mean sleep latency (MSL) threshold for children of 12 min, and assess the impact of a 5th nap. We performed a retrospective analysis of MSLTs at a single paediatric centre from 2004 to 2021. Narcolepsy was defined as a mean sleep latency (MSL) ≤8min with ≥2 sleep onset REM (SOREM) periods. Idiopathic Hypersomnia (IH) was defined as a MSL ≤8min with <2 SOREMs. An ambiguous MSLT result was defined as a MSL 8–12min and/or ≥2 SOREM periods. Of 214 MSLTs [50 % female, median age 14.0y (range 3.3–20.1y)], narcolepsy was diagnosed in 48 (22 %), IH in 22 (10 %) and the result was ambiguous in 44 (21 %). Those with ambiguous MSLT results were older (15.6 vs 13.4y, p = 0.006) with a higher proportion of females (61 % vs 35 %, p = 0.01) in comparison to the narcolepsy group. A 5th nap was performed in 60 (28 %) of MSLTs and only changed the outcome in one case. In conclusion, MSLT results are borderline in 21 % of paediatric cases, suggesting that current adult diagnostic criteria may miss narcolepsy and IH in children. A 5th nap usually makes no difference or increases the MSL, suggesting that a four nap MSLT protocol could be used apart from rare cases where the result is borderline after the 4th nap.

THE COMPARISON SOME MODELS (GAMMA, SLASHED QUASI-GAMMA, THREE PARAMETERS QUASI GAMMA, TWO PARAMETER GAMMA-EXPONENTIAL, AND MODIFIED LOG-LOGISTIC DISTRIBUTIONS) FOR DAILY TEMPERATURE DATA

With the increase in hot temperature events in recent years, there is growing interest in measuring the frequency of recurring temperature events. One of the basis for assessing the frequency of recurrence of temperature events is the probability distribution of temperature events, therefore temperature data is needed to produce statistical modeling, especially in determining the best probability distribution. The study intended to estimate the best-fitted probability model for the daily temperature at the Pekanbaru station in Indonesia from 2010 to 2020 using several statistical analyses. Five continuous probability distributions such as Gamma (GM), Slashed Quasi-Gamma (SQG), Three Parameters Quasi Gamma (TPQG), Two Parameter Gamma-Exponential (TPGE), and Modified Log-Logistic (MLL) distributions were fitted for these tasks using the maximum likelihood technique. To determine the model’s fit to the temperature data, several goodness-of-fit tests were applied, including the graphical methos test (density plot) and Numerical criteria method test (AIC, BIC, and -Log Likelihood). The GM and MLL distribution are found to be the best-fitted probability distribution based on goodness-of-fit tests for the daily temperature data at the Pekanbaru station

Pharmacokinetics and pharmacodynamics of five distinct commercially available hemp-derived topical cannabidiol products.

Products containing cannabidiol (CBD) have proliferated after the 2018 Farm Bill legalized hemp (cannabis with ≤0.3% delta-9-tetrahydrocannabinol (Δ9-THC)). CBD-containing topical products have surged in popularity, but controlled clinical studies on them are limited. This study characterized the effects of five commercially available hemp-derived high CBD/low Δ9-THC topical products. Healthy adults (N = 46) received one of six study drugs: a CBD-containing cream (N = 8), lotion (N = 8), patch (N = 7), balm (N = 8), gel (N = 6) or placebo (N = 9; matched to an active formulation). The protocol included three phases conducted over 17 days: (i) an acute drug application laboratory session, (ii) a 9-day outpatient phase with twice daily product application (visits occurred on Days 2, 3, 7 and 10) (iii) a 1-week washout phase. In each phase, whole blood, oral fluid and urine specimens were collected and analyzed via liquid chromatography with tandem mass spectrometry (LC-MS-MS) for CBD, Δ9-THC and primary metabolites of each and pharmacodynamic outcomes (subjective, cognitive/psychomotor and physiological effects) were assessed. Transdermal absorption of CBD was observed for three active products. On average, CBD/metabolite concentrations peaked after 7-10 days of product use and were highest for the lotion, which contained the most CBD and a permeation enhancer (vitamin E). Δ9-THC/metabolites were below the limit of detection in blood for all products, and no urine samples tested "positive" for cannabis using current US federal workplace drug testing criteria (immunoassay cut-off of 50 ng/mL and confirmatory LC-MS-MS cut-off of 15 ng/mL). Unexpectedly, nine participants (seven lotions, one patch and one gel) exhibited Δ9-THC oral fluid concentrations ≥2 ng/mL (current US federal workplace threshold for a "positive" test). Products did not produce discernable pharmacodynamic effects and were well-tolerated. This study provides important initial data on the acute/chronic effects of hemp-derived topical CBD products, but more research is needed given the diversity of products in this market.

Psychometric analysis of the Hip Disability and Osteoarthritis Outcome Score Joint Replacement (HOOS-JR)

ObjectiveCenters for Medicare and Medicaid Services (CMS) has requested hospitals collect and report patient-reported outcomes (PROs) beginning in 2024 including the Hip Disability and Osteoarthritis Outcome Score Joint Replacement (HOOS-JR). However, scale structural validity of the HOOS-JR has minimally been assessed. The purpose of this study was to assess internal consistency, structural validity, and multi-group invariance properties of the HOOS-JR in a large sample of patients who underwent a total hip arthroplasty (THA). MethodsA cross-sectional study using the Surgical Outcomes System was retrospectively queried for patients who underwent a THA. Internal consistency was assessed using Cronbach's alpha and McDonald's Omega. A confirmatory factor analysis (CFA) was performed on the HOOS-JR using a priori cut-off values. Multi-group invariance testing was also performed on the sample of patients across sex and age groups. ResultsInternal consistency was acceptable for 6-item (alpha ​= ​0.88; omega ​= ​0.88) and 5-item (alpha ​= ​0.86; omega ​= ​0.86) HOOS-JR. The one-factor, 6-item CFA did not meet the recommended fit indices. The one-factor, 5-item CFA had acceptable fit for the sample data. Invariance testing criteria were met between the age groups; however, scalar invariance was not met for sex. ConclusionThe 6-item HOOS-JR did not meet contemporary model fit indices indicating that scale refinement is warranted. The 5-item met most goodness-of-fit indices and invariance criteria. However, further scale refinement may be warranted as localized fit issues were identified.

Hypertension in the emergency department: A missed opportunity to screen for primary aldosteronism?

Primary aldosteronism (PA) is a common but underdiagnosed secondary cause of hypertension. Emergency departments (EDs) often assess patients with severe hypertension or its sequelae, some of whom have underlying PA. We aimed to determine the proportion of patients presenting to the ED with hypertension who meet the Endocrine Society criteria for PA testing and the proportion who were screened. We performed a structured retrospective chart review of adults who presented to three EDs in an Australian tertiary health network between August 2019 and February 2020, with a coded presenting complaint of hypertension. Clinical parameters to determine whether the patients met the criteria for PA testing were extracted from electronic medical records. Of the 418 patients who presented to the EDs with documented elevated blood pressure (BP), 181 patients (43.3%) fulfilled PA screening criteria and nine patients (2.2%) underwent PA testing. Individuals who fulfilled screening criteria were older; had higher prevalence of Type 2 diabetes, coronary artery disease, and congestive heart failure; took more antihypertensive medications; and had lower estimated glomerular filtration rate. Individuals who were tested for PA were younger and had higher BP on presentation. Screening for PA was more frequent in patients who were referred to medical teams. As far as we are aware, our study is the first to evaluate PA testing in hypertensive patients who present to ED. More than 40% of adults presenting to the EDs with hypertension met the current criteria for testing for PA but only few were tested. These results emphasize that increased awareness of PA in the ED is needed to encourage opportunistic testing, referral, and treatment, especially in patients who present with hypertensive emergencies. Prospective studies are required to determine the feasibility and effectiveness of this.

A protocol for a systematic review and meta-analysis of tuberculosis care around the time of pregnancy.

Tuberculosis is estimated to cause 1.5 million deaths annually and is most common during the reproductive years. Despite that fact, we found that tuberculosis screening, prevention or care recommendations for people around the time of pregnancy were absent from some national policy recommendations and varied in others. To address the apparent gaps and inconsistencies in policy, we aim to design a systematic review and meta-analysis of the original research evidence informing tuberculosis care around the time of pregnancy. With assistance from librarians at the Biomedical library of the University of Gothenburg, Pubmed, CINAHL and Scopus databases will be searched. Search terms will aim to identify studies generating original research evidence informing care for tuberculosis around the time of pregnancy. Evidence may include: the outcome of TB and/or of pregnancy; the cost-effectiveness or acceptability of any intervention; the sensitivity and specificity of any assessment, selection, diagnostic or test criterion. The output from these literature searches will be screened by two independent reviewers to select the eligible studies for inclusion. Discrepancies will be resolved with a third reviewer. Firstly, publications that provide contextual data will be tabulated, summarising their main contributions. Secondly, studies that provide evidence directly guiding patient care will be our focus and will be considered to be key. The key studies will be subject to quality assessment, data extraction and when possible, meta-analysis. This systematic review and meta-analysis aims to guide policy, practice and future research priorities concerning tuberculosis care around the time of pregnancy.

AN ITEM ANALYSIS OF THE ENGLISH SUMMATIVE TEST FOR THE SEVENTH GRADE STUDENTS OF SMPN 12 TANGERANG SELATAN

The objective of this study is to find out whether or not the English summative test for the Seventh Grade Students of SMPN 12 Tangerang Selatan can be categorized as a good test based on the difficulty level, the discriminating power and the effectiveness of distracters. The respondents of this study were the seventh grades students of SMP Negeri 12 Tangerang Selatan. The respondents of this study were taken from two classes. The number of this population was 68 students. The students of each class consist of 38 and 30 students. The number of sample of this study was 34 respondents, 17 respondents of the upper group and 17 respondents of the lower group. The method of the study was descriptive quantitative and qualitative method. In analyzing the difficulty level and the discriminating power, the writer used the formula suggested by Heaton to analyze the difficulty level and the formula suggested by Hopkin and Antes to analyze the discriminating power. After analyzing the difficulty level, there have been 24 items which categorized in the easy level, 24 items which categorized in the medium level, and 2 items which categorized in the difficul level. In terms of the discriminating power, there have been 37 items can be accepted, 10 items should be revised, and 3 items should be discarded. Based on the results of the difficulty level and the discriminating power, it can be concluded that the test fulfills the criteria of a good test.

Will it run?-A proof of concept for smoke testing decentralized data analytics experiments.

The growing interest in data-driven medicine, in conjunction with the formation of initiatives such as the European Health Data Space (EHDS) has demonstrated the need for methodologies that are capable of facilitating privacy-preserving data analysis. Distributed Analytics (DA) as an enabler for privacy-preserving analysis across multiple data sources has shown its potential to support data-intensive research. However, the application of DA creates new challenges stemming from its distributed nature, such as identifying single points of failure (SPOFs) in DA tasks before their actual execution. Failing to detect such SPOFs can, for example, result in improper termination of the DA code, necessitating additional efforts from multiple stakeholders to resolve the malfunctions. Moreover, these malfunctions disrupt the seamless conduct of DA and entail several crucial consequences, including technical obstacles to resolve the issues, potential delays in research outcomes, and increased costs. In this study, we address this challenge by introducing a concept based on a method called Smoke Testing, an initial and foundational test run to ensure the operability of the analysis code. We review existing DA platforms and systematically extract six specific Smoke Testing criteria for DA applications. With these criteria in mind, we create an interactive environment called Development Environment for AuTomated and Holistic Smoke Testing of Analysis-Runs (DEATHSTAR), which allows researchers to perform Smoke Tests on their DA experiments. We conduct a user-study with 29 participants to assess our environment and additionally apply it to three real use cases. The results of our evaluation validate its effectiveness, revealing that 96.6% of the analyses created and (Smoke) tested by participants using our approach successfully terminated without any errors. Thus, by incorporating Smoke Testing as a fundamental method, our approach helps identify potential malfunctions early in the development process, ensuring smoother data-driven research within the scope of DA. Through its flexibility and adaptability to diverse real use cases, our solution enables more robust and efficient development of DA experiments, which contributes to their reliability.

Les actualités en génétique oncologique mammaire pour la population féminine et masculine

ObjectivesBreast oncology genetics emerged almost 30 years ago with the discovery of the BRCA1 and BRCA2 genes. The evolution of analytical practices has progressively allowed access to tests whose results now have a considerable impact on the management of both female and male breast cancers. The Sénologie commission of the Collège national des gynécologues et obstétriciens français (CNGOF) asked five specialists in breast surgery, oncology and oncological genetics to draw up a summary of the oncogenetic testing criteria used and the clinical implications for the female and male population of the test results, with or without an identified causal variant. In the case of proven genetic risk, surveillance, risk-reduction strategies, and the specificities of surgical and medical management (with PARP inhibitors in particular) were updated. MethodsThis summary was based on national and international guidelines on the monitoring and therapeutic management of genetic risk, and a recent review of the literature covering the last five years. ResultsDespite successive technical developments, the probability of identifying a causal variant in a situation suggestive of a predisposition to breast and ovarian cancer remains around 10% in France. The risk of breast cancer in women with a causal variant of the BRCA1, BRCA2, PALB2, TP53, CDH1 and PTEN genes is estimated at between 35% and 85% at age 70. The presence of a causal variant in one of these genes is the subject of different recommendations for men and women, concerning both surveillance, the age of onset and imaging modalities of which vary according to the genes involved, and risk-reduction surgery, which is possible for women as soon as their risk level exceeds 30% and remains exceptionally indicated for men. In the case of breast cancer, PARP inhibitors are a promising new class of treatment for BRCA germline mutations. ConclusionA discipline resolutely focused on understanding molecular mechanisms, screening and preventive medicine/surgery, oncology genetics is currently also involved in new medical/surgical approaches, the long-term benefits/risks of which will need to be monitored.