Organized crime is one of the most serious security threats that may face any country in the world, due to its global effects that transcend the states’ borders, hence the main research question of this paper is “to what extent is the spread of organized crime in the Central Asian region reflected on the security and stability of the Arab region?”, So the paper clarified the definition of organized crime, with an explanation of the nature of organized crime In more detail in both Central Asia and the Arab region, supported by the findings of the Global Organized Crime Index issued in 2021. The paper concluded that there is a significant impact of the spread of organized crime in the Central Asian region on the Arab region; As drugs and weapons move from the Central Asian countries to the Arab countries through Iran, organized criminal groups also have a role in the crimes of human trafficking and illegal immigration from affected Arab areas by civil wars and terrorism to Europe. In this context, the paper puts forward two main policy alternatives for the Arab decision-makers, namely strengthening the steadfastness of countries, and adopting unconventional methods to reach the best results in confronting organized crime. Finally, the paper laid out a set of recommendations to enhance information exchange between the Arab countries, enhance regional cooperation in the technological field, as well as undertake local initiatives that include all segments of society in the process of confronting organized crime.