Objectives. To examine levels and temporal changes in the frequency of defensive gun use by US crime victims. Methods. We computed national-level counts of criminal incidents involving firearm defense during 3 periods: 1993 to 2005, 2007 to 2015, and 2016 to 2021. We also considered earlier national estimates for 1987 to 1990. The data came from the US Bureau of Justice Statistics National Crime Victimization Survey (NCVS). We counted firearm defenses as incidents in which victims used a gun to threaten or attack an offender. Results. Over the 4 periods, for all crimes, victims reported gun defenses in an average range of between 61 000 and 65 000 incidents per year. This included between 38 000 and 53 000 personal (violent) incidents and between 12 000 and 23 000 household (property) incidents. Conclusions. Firearm defenses occurred at a relatively low and nearly constant level over the 35-year period. Although some victims use guns for defense, these uses are infrequent compared with the incidence of crime. Public Health Implications. The continuing relative rarity of NCVS armed defenses suggests that claims about the protective benefits of widespread firearm ownership may be overstated. (Am J Public Health. 2024;114(12):1384-1387. https://doi.org/10.2105/AJPH.2024.307838).