We present new field observations, whole-rock major and trace elements, Sr-Nd-Pb-Hf isotopes and zircon UPb ages for the Mesozoic granites in the Mufushan complex, eastern South China. The age determinations by LA-ICP-MS UPb dating of zircons indicate that the porphyritic biotite granites and two-mica monzogranites have ages of ∼136 Ma and ∼ 130 Ma, respectively. These granites display highly evolved S-type granite geochemical characteristics, with high SiO2 (70–74 wt%) contents, high 10000*Ga/Al ratios (2.3–3.2, average of 2.8) and weakly peraluminous (A/CNK > 1.1). Both types of granites are enriched in large ion lithophile elements (LILEs, e.g., Rb, K, Ba, Sr) and depleted in high field strength elements (HFSEs, e.g., Nb, Ta, Ti), with negative anomalies of Eu and positive anomalies of Pb, which are akin to continental arc rocks. The two-mica monzogranites have high 87Sr/86Sr(i) (0.71355–0.71535), 206Pb/204Pb(i) (18.105–18.157), low εNd(t) (−9.1 to −9.6) and εHf(t) (−4.1 to −10.4), similar to those of the porphyritic biotite granites which are characterized by high 87Sr/86Sr(i) (0.717337–0.71692), 206Pb/204Pb(i) (18.134–18.580), low εNd(t) (−9.1 to −9.7) and zircon εHf(t) (−6.8 to −3.3). The similar emplacement ages and mineral assemblages as well as Sr-Nd-Hf isotopic signatures indicate their derivations were likely derived from a common magma source. These early Cretaceous granites yield two-stage Nd model ages of 1.6–1.7 Ga, similar to the two-stage Hf model ages of 1.3–1.8 Ga. The presence of Neoproterozoic and subordinate Mesoproterozoic zircons within the granitic rocks suggest a significant contribution of ancient crustal materials involved in the genesis of the magmas. In combination with comprehensive studies on the magmatic rocks, the early Cretaceous Mufushan granitic rocks may have experienced an extensive enrichment process, contemporaneously with partial melting of the Neoproterozoic volcanic-sedimentary sequences that produced the arc-like rocks. Almost simultaneously, an extensional event caused by the subduction and slab roll-back of the Paleo-Pacific plate (Izanagi plate) dominates the middle-late Mesozoic tectonics in eastern South China. This extensional regime was accompanied by the underplating of mantle-derived magma and crustal melting, producing the widespread early Cretaceous granites in adjacent regions. The development of coeval basin-and-range structures with the production of contemporaneous magmatic rocks and related polymetallic deposits in eastern South China are all related to slab roll-back tectonics.