In order to investigate the effect of curved track support failure on railway vehicle derailment, a coupled vehicle–track dynamic model is put forward. In the model, the vehicle and the structure under rails are, respectively, modelled as a multi-body system, and the rail is modelled with a Timoshenko beam rested on the discrete sleepers. The lateral, vertical, and torsional deformations of the beam are taken into account. The model also considers the effect of the discrete support by sleepers on the coupling dynamics of the vehicle and track. The sleepers are assumed to move backward at a constant speed to simulate the vehicle running along the track at the same speed. In the calculation of the coupled vehicle and track dynamics, the normal forces of the wheels/rails are calculated using the Hertzian contact theory and their creep forces are determined with the nonlinear creep theory by Shen et al [Z.Y. Shen, J.K. Hedrick, and J.A. Elkins, A comparison of alternative creep-force models for rail vehicle dynamic analysis, Proceedings of the 8th IAVSD Symposium, Cambridge, MA, 1984, pp. 591–605]. The motion equations of the vehicle/track are solved by means of an explicit integration method. The failure of the components of the curved track is simulated by changing the track stiffness and damping along the track. The cases where zero to six supports of the curved rails fail are considered. The transient derailment coefficients are calculated. They are, respectively, the ratio of the wheel/rail lateral force to the vertical force and the wheel load reduction. The contact points of the wheels/rails are in detail analysed and used to evaluate the risk of the vehicle derailment. Also, the present work investigates the effect of friction coefficient, axle load and vehicle speed on the derailments under the condition of track failure. The numerical results obtained indicate that the failure of track supports has a great influence on the whole vehicle running safety.