In rarefied gas dynamics, the Cercignani-Lampis (CL) scattering kernel, containing two accommodation coefficients (ACs), namely the tangential momentum and normal energy ones, is widely employed to characterize gas-surface interaction, particularly in non-isothermal setups, where both momentum and energy may simultaneously be exchanged. Here, a formal and detailed sensitivity analysis of the effect of the CL ACs on the main output quantities of several prototype problems, namely the cylindrical Poiseuille, thermal creep and thermomolecular pressure difference (TPD) flows, as well as the plane Couette flow and heat transfer (Fourier flow), is performed. In each problem, some uncertainties are randomly introduced in the ACs (input parameters) and via a Monte Carlo propagation analysis, the deduced uncertainty of the corresponding main output quantity is computed. The output uncertainties are compared to each other to determine the flow configuration and the gas rarefaction range, where a high sensitivity of the output quantities with respect to the CL ACs is observed. The flow setups and rarefaction regimes with high sensitivities are the most suitable ones for the estimations of the ACs, since larger modeling and experimental errors may be acceptable. In the Poiseuille and Couette flows, the uncertainties of the flow rate and shear stress respectively are several times larger than the input uncertainty in the tangential momentum AC and much smaller than the uncertainty in the normal energy AC in a wide range of gas rarefaction. In the thermal creep flow, the uncertainty of the flow rate depends on the input ones of both ACs, but, in general, it remains smaller than the input uncertainties. A similar behavior with the thermal creep flow is obtained in the TPD flow. On the contrary, in the Fourier flow, the uncertainty of the heat flux may be about the same or even larger than the input ones of both ACs in a wide range of gas rarefaction. It is deduced that in order to characterize the gas-surface interaction via the CL ACs by matching computations with measurements, it is more suitable to combine the Poiseuille (or Couette) and Fourier configurations, rather than, as it is commonly done, the Poiseuille and thermal creep ones. For example, in order to estimate the normal energy AC within an accuracy of 10 %, experimental uncertainties should be less than 4 % in the thermal creep or TPD flows, while may be about 10 % in the Fourier flow.
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