The seepage action of underground water accelerates the deformation of roadway surrounding rock in deep mines. Therefore, the study of creep characteristics of surrounding rock under seepage action is the basis for the stability control of roadway surrounding rock in deep water-rich areas. In this paper, a seepage-creep coupling test system for complete rock samples was established. Combined with a scanning electron microscopy (SEM) test system, the seepage-creep law of coal measures sandstone and the damage mechanism were revealed. The study results showed that the maximum creep deformation of sandstone under natural and saturation state decreased gradually with the increase of confining pressure, and the maximum creep deformation under saturation state was greater than the corresponding value under natural state when the confining pressure was same. When the confining pressure was constant, the creep deformation, the constant creep deformation rate and the accelerated creep deformation rate of sandstone increased rapidly with the increase of infiltration pressure. With the change of time, the change of permeability parameters went through three cycles; each cycle was divided into two stages, slow change stage and rapid change stage, and the rate of variation increased with the increase of the seepage pressure. Based on the macroscopic and microscopic characteristics of sandstone rupture, the connection between macroscopic and microscopic mechanism on sandstone rupture was established. The results in this paper can provide a theoretical basis for stability control of roadway surrounding rock in water-rich areas.