CS Group Research Articles

Clinical predictors and outcomes of ST-elevation myocardial infarction related cardiogenic shock in the Asian population

BackgroundCardiogenic shock (CS) complicating myocardial infarction is associated with poor outcomes. Data among Asian populations are scarce. We aimed to investigate the long-term outcomes, prognostic factors, and predictors of CS among Asian ST elevation myocardial infarction (STEMI) patients. MethodsThis was a retrospective cohort study of consecutive patients undergoing primary percutaneous coronary intervention (PPCI) for STEMI within our regional STEMI network between 2015 and 2019. The long-term outcomes of those with and without CS were compared. Clinical predictors of outcomes and development of CS were investigated. ResultsA total of 1791 patients who underwent PPCI were included. Patients completed at least 2 years’ follow-up with a median follow-up period of 2.6 years (IQR 1.0, 3,9). Overall, 208/1791 (11.6 %) STEMI patients developed CS. These patients were older (61.1 ± 12.5 vs 57.8 ± 12.2, P < 0.001) and mostly men (87.0 %). All-cause mortality (59.9 % vs 4.7 % P < 0.001), cardiac mortality (43.8 % vs 2.2 %, P < 0.001) and major adverse cardiovascular events (MACE) was significantly higher in the CS group (59.1 % vs 14.0 %, P < 0.001). Independent predictors of survival were higher index LVEF (adjusted hazards ratio [aHR] 0.967, 95 %CI 0.951–0.984, p < 0.001) and higher arterial pH at onset of shock (aHR 0.750, 0.626–0.897, p = 0.002). Increased serum lactate concentration independently predicts poor prognosis (aHR 1.084, 95 % CI 1.046–1.124, p < 0.001). ConclusionIn Asian STEMI patients who underwent PPCI, CS was associated with poor outcomes. Higher LVEF on index admission was associated with better outcomes; while lactic acidosis independently predicted mortality.

Research and Thinking Based on Credit Suisse Bank Crisis

Research and Thinking Based on Credit Suisse Bank Crisis

Comparison of Bilirubin Level in Term Infants Born by Vaginal Delivery and Cesarean Section Delivery

Background: Given the overriding importance of neonatal jaundice and scarcity of studies on the role of route of delivery on its occurrence, this study aimed to investigate the association between neonatal bilirubin level and the route of delivery (i.e., normal vaginal delivery [NVD] and cesarean section [CS]). Methods: This prospective, cross-sectional study was conducted in 2012- in Accadmic hospital of medical faculty of balkh university Afghanistan, in all term infants, who met the inclusion criteria was serum bilirubin level was measured by the bili-test device between the second and seventh days after birth. In cases with skin bilirubin level&gt;5 mg/dl, serum bilirubin was also checked. Results: A total of 182 neonates were enrolled in the study, 56% of whom were male. The mean bilirubin levels in the NVD and CS groups were 9.4±2.9 mg/dl and 9.8±3.4 mg/dl, respectively (P=0.53). Additionally, comparison of the mean bilirubin levels between the two groups based of demographic characteristics demonstrated no significant differences. Conclusion: This study showed no significant correlation between neonatal jaundice in term infants and the route of delivery.

Mapping Capital Ratios to Bank Lending Spreads: The Role of Efficiency and Asymmetry in Performance Indices

Beyond the 2007–2008 financial crisis, the collapse of the Silicon Valley Bank and the acquisition of Credit Suisse by the Swiss investment bank UBS Group AG in 2023 have brought fresh attention to the need for new regulatory capital, liquidity risk management, and leverage requirements. To meet tightened capital requirements, banks have to increase their capital ratios either by increasing equity or by decreasing risk-weighted assets. Both options lead to banks’ performance deterioration. One remedy for banks to recover is raising their lending spread. A critical question is how much the lending spread should be increased to offset the drop in the bank’s financial performance level. In this study, we focus on the asymmetries and efficiency consequences of performance indices such as economic value added (EVA) and the more commonly used return on equity (ROE) in determining the loan spread. Using data on the largest U.S. banks over the period 2018–2022, our results show that the ROE rule significantly overestimates the magnitude of the lending spreads required to offset the negative financial consequences of increases in capital ratios. The EVA approach, on the other hand, prescribes on average a significantly lower lending spread of 0.4505 basis points against a lending spread of 21.0441 basis points associated with the use of the ROE approach. The efficiency and the level of lending spreads should enable banks to maintain their competitive advantages in the loan markets impacting overall economic productivity and growth.

P-167 The sperm parameters in doubling oocytes by the 1st polar body transfer technique: does it matter?

Abstract Study question Does sperm parameters affect the effectiveness of the 1st polar body (PB) transfer in oocytes and embryo doubling? Summary answer Certain sperm conditions affect the transfer technique efficiency. What is known already Previous studies have shown the effectiveness of the 1st polar body (PB) transfer. The technique allows for the modification of donor oocytes to increase the number of cells suitable for fertilization and at the same time preserve the genetic relatedness to the patient. We established that the effectiveness depends on the morphology of the 1stPB. We also showed that the yield of high-quality blastocysts does not depend on whether fresh or thawed donor oocytes are used. But it is also important to understand whether sperm parameters have a significant effect on the performance of the technique. Study design, size, duration The study was performed in the Medical Center IGR from December 2017 to December 2023 and involved 93 patients (mean age 39.7±5.4 years) who underwent the 1st PB transfer and had indicated sperm parameters used for fertilization, including: normozoospermia (NS, n = 43), asthenozoospermia (AS, n = 24), asthenoteratozoospermia (ATS, n = 20), oligozoospermia (OS, n = 5), cryptozoospermia (CS, n = 1). We evaluated the pronuclear scoring, number of embryos on the 3rd and the 5th post-fertilization day, euploidy according to sperm conditions. Participants/materials, setting, methods We used donor oocytes, patients’ oocytes and their 1stPBs obtained from 93 women and their partners sperm with defined parameters in accordance with WHO norms for 2021. The procedure of donor oocyte enucleation and the 1stPBs transfers was carried out using Nikon Ti Eclipse(Japan) inverted microscope, Saturn 3 laser console(UK). Preimplantation genetic testing for aneuploidy was performed using trophectoderm biopsy. Samples were diagnosed using Ion S5(USA). Statistical analysis was carried out using Chi-square test. Main results and the role of chance The total number of donor oocytes modified by the 1stPB of patient’ oocytes was 364, which were distributed as follows by sperm status: NS - 159 oocytes, AS - 103 oocytes, ATS - 77 oocytes, OS - 19 oocytes, and CS - 6 oocytes. The mean age of the female patients according to the groups was similar (39.6±4.9, 39.8±6.2, 40.0±3.8, 37.8±6.1,40, respectively). The number of 2PN pattern during pronuclear scoring was distributed among groups (NS:AS:ATS:OS:CS) with the following percentages 69.2:65.1:62.3:73.7:66.7, respectively. Among the developing embryos on the 3rdday the distribution was 46.6:46.5:36.4:57.9, respectively. No viable embryos were formed in the CS group, so the group was not included in further calculations. Statistically significant difference (SSD) was not found between the groups on the above-mentioned stages of development (p0.05). On the 5thday the number of developing embryos (percents) was distributed as follows: 23.3:28.2:11.7:31.6 for NS:AS:ATS:OS, respectively. It is worth noting that SSD was found between NS and ATS, OS and ATS groups (p &amp;lt; 0.05) and AS and ATS groups (p &amp;lt; 0.001). Percentage of euploid embryos relative to the number of examined blastocysts from groups NS:AS:ATS was 30.8:23.1:22.2, respectively, SSD wasn’t found between the groups(p &amp;gt; 0.05). Limitations, reasons for caution To increase performance of the 1st PB transfer technique it is also worth considering such parameters as sperm DNA fragmentation and level of sperm oxidative stress, which reflect the chromatin state of the male gamete. Wider implications of the findings The study showed that among patients with asthenoteratozoospermia, the yield of viable embryos was significantly lower compared to the other sperm conditions studied. This fact must be taken into account when predicting the result of using the 1st PB transfer technique. Trial registration number N/A

Skoochies and its component substances induced testicular damage and impaired sperm function via increased generation of reactive oxygen species and impairment of the glutathione system in rats

ObjectiveTo study examined the effect of skoochies, an illicit cocktail drink, on testicular and sperm function in male rats. DesignTwenty-five adult male Wistar rats were assigned randomly into five groups (n = 5), as follows: Normal saline (NS group), skoochies (SK group), cannabis sativa (CS group), codeine (CO group), and tramadol (TM group). The cocktail (skoochies) used for this study was formulated using the following composition: codeine (5mg/kg), tramadol (20mg/kg) and cannabis extract (2mg/kg). These doses are as previously reported. Administration was done once daily for twenty-eight (28) days. ResultsSkoochies increased reactive oxygen species generation and impaired the antioxidant system resulting in inflammation that eventually damage the testicular tissue. Skoochies causes oxido-inflammatory injury to the testicular tissues resulting in impaired testicular functions. This was evident by the distorted cytoarchitecture, reduced sperm count, motility and impaired testicular DNA integrity. ConclusionThus, our results infer that Skoochies induced the impairment of testicular and sperm function through the increased generation of reactive oxygen species and impairment of the glutathione system.

Physicochemical characteristics and microbial diversity of sous vide scallops (Chlamys farreri) during chilled storage

This study investigated the impact of sous vide (SV) cooking methods on the physical and chemical characteristics as well as the microbial composition of scallops (Chlamys farreri) over a 30 days period of refrigerated storage. Scallop treatments were divided into two groups: CS (scallops vacuum-packed and then steamed for 30 min at 75 °C) and CK (scallops steamed for 15 min at 100 °C). With the increase in refrigeration time, the total volatile basic nitrogen (TVBN), pH, cooking loss, microbial content, and malondialdehyde (MDA) content gradually increased, while the water-soluble protein extraction rate and the myofibrillar protein (MP) extraction rate of the CS and CK samples significantly decreased. Notably, the SV steaming treatment effectively reduced microbial degradation of proteins, improved water retention of scallop samples, and maintained high MP extraction as compared to CK samples (MP content ranged from 1.09% to 2.50% in the CK group and 1.75%–3.33% in the CS group). During the late stages of refrigeration, conventionally cooked scallops (CK) were dominated by Pseudomonas and Psychrobacter, with the ability to produce biogenic amines, while SV steamed scallops were dominated by Psychrobacillus. Furthermore, a link was discovered between the microbial community and the physicochemical parameters.

Quantifying the volatility spillover dynamics between financial stress and US financial sectors: Evidence from QVAR connectedness

This study uses quantile vector-autoregressive to examine volatility connectedness among a global financial stress index (including five categories: credit, equity valuation, funding, safe assets, and volatility) and US financial sectors under low, moderate, and extreme volatility conditions. The dataset includes the special periods covering the global financial crisis, China crisis, COVID-19 pandemic, Russian–Ukrainian war, Silicon Valley Bank failure, and Credit Suisse bank crisis. The findings imply that spillover effects among the series are higher during extreme volatility than during low and moderate volatility periods. During periods of low volatility, the credit category of the financial stress index and the US financial sector indices are net shock transmitters, but during extreme volatility periods, the US financial sectors become net shock receivers alongside the credit and funding categories of the financial stress indices. US financial sectors also exhibit net shock recipient roles at extreme volatility levels during those special periods.

A validation study of the accuracy of the atrial pace map assessed with intracardiac pattern matching: Potential utility of non-pulmonary vein mapping.

Identification of infrequent nonpulmonary vein trigger premature atrial contractions (PACs) is challenging. We hypothesized that pace mapping (PM) assessed by correlation scores calculated by an intracardiac pattern matching (ICPM) module was useful for locating PAC origins, and conducted a validation study to assess the accuracy of ICPM-guided PM. Analyzed were 30 patients with atrial fibrillation. After pulmonary vein isolation, atrial pacing was performed at one or two of four sites on the anterior and posterior aspects of the left atrium (LA, n=10/10), LA septum (n=10), and lateral RA (n=10), which was arbitrarily determined as PAC. The intracardiac activation obtained from each pacing was set as an ICPM reference consisting of six CS unipolar electrograms (CS group) or six CS unipolar electrograms and four RA electrograms (CS-RA group). The PM was performed at 193±107 sites for each reference pacing site. All reference pacing sites corresponded to sites where the maximal ICPM correlation score was obtained. Sites with a correlation score ≥98% were rarely obtained in the CS-RA than CS group (33%vs. 55%, P=.04), but those ≥95% were similarly obtained between the two groups (93%vs. 88%, P=.71), and those ≥90% were obtained in all. The surface areas with correlation scores ≥98% (0[0,10] vs. 10[0,35] mm2, P=.02), ≥95% (10[10,30] vs. 50[10,180] mm2, P=.002) and ≥90% (60[30,100] vs. 170[100,560] mm2, P=.0002) were smaller in the CS-RA than CS group. ICPM-guided PM was useful for identifying the reference pacing sites. Combined use of RA and CS electrograms may improve the mapping quality.

Risk Assessment of Banks under Fed Rate Hikes

The global economy was hit after the start of the COVID-19 pandemic. Economic stagnation and high volatility in commodity prices also had a negative impact on global supply chains. The Federal Reserve, in an effort to prevent a repeat of the 2008 financial crisis, slow down inflation, increase the liquidity of money, prevent asset value bubbles, and further revive and stabilize the economy, adopted a policy of raising interest rates, gradually increasing the federal funds rate to between 5.25 and 5.5 per cent over a two-year period. This change, however, also led to many changes in the banking sector. Commercial banks are trying to find ways to avoid risks while maintaining their returns in the face of financial market changes. This paper analyzes the systemic risk of commercial banks through liquidity risk, credit risk and market risk with the cases of Silicon Valley Bank, Signature Bank and Credit Suisse Bank. Through the analysis, this paper finds that commercial banks suffer from systemic risk, often reflecting their own operational problems, which ultimately led to bankruptcy or acquisition of the end.

Switzerland: Political Developments and Data in 2023

AbstractIn 2023, Switzerland's profound integration into the globalized world was particularly evident, fundamentally challenging the notion of political sovereignty. Yet, this interconnectedness also means that Swiss domestic rules strongly reverberate around the world, such as in the case of policy failure regarding financial regulation. This article explores how global developments shape Swiss politics, from campaign dynamics ahead of the 2023 federal elections to externally imposed legislative agendas. Even the notorious “Swiss” direct democracy no longer solely reflects citizen‐initiated proposals as further evidenced that year. The article also underscores the inertia of Swiss‐style consensus democracy in gearing up its institutional design for polycrisis. It concludes with a discussion of two major political issues: the collapse of Credit Suisse, one of Switzerland's two leading banks, which marks the most far‐reaching shake‐up of the global banking sector since the 2008 financial crisis, and a potential break‐through in the longstanding stalemate in Swiss–EU relations.

Neoadjuvant Chemotherapy Does Not Improve Survival in cT2N0M0 Gastric Adenocarcinoma Patients: A Multicenter Propensity Score Analysis

BackgroundAccording to current international guidelines, stage cT2N0M0 gastric adenocarcinoma warrants preoperative chemotherapy followed by surgery. However, upfront surgery is often preferred in clinical practice, depending on patient clinical status and local treatment preferences.ObjectiveThe aim of the present study was to assess the impact of neoadjuvant chemotherapy in overall survival (OS) and disease-free survival (DFS) of cT2N0M0 patients.MethodsA retrospective analysis was performed among 32 centers, including gastric adenocarcinoma patients operated between January 2007 and December 2017. Patients with cT2N0M0 stage were divided into upfront surgery (S) and neoadjuvant chemotherapy followed by surgery (CS) groups. Inverse probability of treatment weighting (IPTW) was used to compensate for baseline differences between the groups.ResultsAmong the 202 patients diagnosed with cT2N0M0 stage, 68 (33.7%) were in the CS group and 134 (66.3%) were in the S group. CS patients were younger (mean age 62.7 ± 12.8 vs. 69.8 ± 12.1 years for S patients; p < 0.001) and had a better health status (World Health Organization performance status = 0 in 60.3% of CS patients vs. 34.5% of S patients; p = 0.006). During follow-up, recurrence occurred in 27.2% and 19.6% of CS and S patients, respectively, after IPTW (p = 0.32). Five-year OS was similar between CS and S patients (78.9% vs. 68.3%; p = 0.42), as was 5-year DFS (70.4% vs. 68.5%; p = 0.96). Neoadjuvant chemotherapy was associated with neither OS nor DFS in multivariable analysis after IPTW.ConclusionsPatients with cT2N0M0 gastric adenocarcinoma did not present a survival or recurrence benefit if treated with perioperative chemotherapy followed by surgery as opposed to surgery alone.

Metformin attenuates lung ischemia-reperfusion injury and necroptosis through AMPK pathway in type 2 diabetic recipient rats

BackgroundDiabetes mellitus (DM) can aggravate lung ischemia-reperfusion (I/R) injury and is a significant risk factor for recipient mortality after lung transplantation. Metformin protects against I/R injury in a variety of organs. However, the effect of metformin on diabetic lung I/R injury remains unclear. Therefore, this study aimed to observe the effect and mechanism of metformin on lung I/R injury following lung transplantation in type 2 diabetic rats.MethodsSprague–Dawley rats were randomly divided into the following six groups: the control + sham group (CS group), the control + I/R group (CIR group), the DM + sham group (DS group), the DM + I/R group (DIR group), the DM + I/R + metformin group (DIRM group) and the DM + I/R + metformin + Compound C group (DIRMC group). Control and diabetic rats underwent the sham operation or left lung transplantation operation. Lung function, alveolar capillary permeability, inflammatory response, oxidative stress, necroptosis and the p-AMPK/AMPK ratio were determined after 24 h of reperfusion.ResultsCompared with the CIR group, the DIR group exhibited decreased lung function, increased alveolar capillary permeability, inflammatory responses, oxidative stress and necroptosis, but decreased the p-AMPK/AMPK ratio. Metformin improved the function of lung grafts, decreased alveolar capillary permeability, inflammatory responses, oxidative stress and necroptosis, and increased the p-AMPK/AMPK ratio. In contrast, the protective effects of metformin were abrogated by Compound C.ConclusionsMetformin attenuates lung I/R injury and necroptosis through AMPK pathway in type 2 diabetic lung transplant recipient rats.

Motivation of Financial Decision-Making in the Era of Mass Media: An Interpretation of the Influence of Media Discourse on Credit Suisse Group Customer Behavior

This paper aims to interpret the media's influence on customer behavior within the Credit Suisse Group from the vantage point of social psychology, elucidating the underlying drivers of financial decision-making in the age of mass media. Through an analysis encompassing the relationship between financial decision-making and social psychology theories, the distinctive features characterizing Credit Suisse Group's customer behavior, and the impact of media discourse on customer conduct, this study delves into the role of social cognition in shaping customer behavior as well as the affective ramifications of media discourse on customers. The findings underscore the pivotal roles of social cognition and media discourse in financial decision-making. This study holds significant theoretical implications and practical relevance for comprehending the impetuses behind financial decisions and the sway of mass media on customer behavior.

Impact of Nanoencapsulated Rosemary Essential Oil as a Novel Feed Additive on Growth Performance, Nutrient Utilization, Carcass Traits, Meat Quality and Gene Expression of Broiler Chicken.

This study evaluated the effect of free and nanoencapsulated rosemary essential oil (REO) as an antibiotic alternative in broiler diets on growth performance, nutrient digestibility, carcass traits, meat quality and gene expression. Four hundred twenty day-old commercial broiler chicks (VENCOBB) were randomly allocated to seven dietary treatments, each having four replicates of fifteen chicks. The dietary treatments comprised control (CON) fed a basal diet only, AB (basal diet + 10 mg enramycin/kg), CS (basal diet + 150 mg chitosan nanoparticles/kg), REOF100 and REOF200 (basal diet + 100 mg and 200 mg free REO/kg, respectively), and REON100 and REON200 (basal diet + 100 mg and 200 mg nanoencapsulated REO/kg, respectively). Overall (7-42 d), REON200 showed the highest (p < 0.001) body weight gain (1899 g/bird) and CON had the lowest gain (1742 g/bird), while the CS, REOF100 and REOF200 groups had a similar gain, but lower than that of the AB and REON100 groups. Feed intake was not affected by dietary treatments. Overall, the feed efficiency increased (p = 0.001) by 8.47% in the REON200 group and 6.21% in the AB and REON100 groups compared with the CON. Supplementation of REO improved (p < 0.05) dry matter and crude protein digestibility, with the highest values in REON100 and REON200. Ether extract, crude fiber, calcium and phosphorus digestibility values showed no difference among the groups. The dressing, breast, thigh % increased (p < 0.05) and abdominal fat % decreased (p < 0.001) more in the REON200 group than with other treatments and CON. In breast meat quality, water holding capacity and extract reserve volume increased (p < 0.05) while drip loss and cholesterol content decreased (p < 0.05) in REON100 and REON200. No change was observed in the breast meat color among dietary treatments and CON. The REON100 and REON200 groups had reduced (p < 0.05) meat lipid peroxidation as depicted by the decreased levels of TBARS, free fatty acids and peroxide value compared to other treatments and CON. The expression of the Mucin 2, PepT1 and IL-10 genes was upregulated (p < 0.001) and TNF-α downregulated (p < 0.001) by dietary addition of REO particularly in the nanoencapsulated form compared with the CON. In conclusion, nanoencapsulated REO, especially at 200 mg/kg diet, showed promising results as an antibiotic alternative in improving the performance, nutrient digestibility, carcass traits, meat quality and upregulation of growth and anti-inflammatory genes.

Questionable relations: On aggressive financialised ‘assemblages’ in creative and ecologically-challenged space-economies

In this contribution, the interest is in three things, arising from a project on ‘dark’ F-KIBS clusters. This has already resulted in critical papers on management consultancy and accounting ‘assemblages’ in which such clusters are embedded (Cooke, 2023a; 2003b). Questions posed are: first, why is there so much financial crime being punished with huge fines? Second has there been a significant rise in such prosecutions in recent years? Third, which jurisdictions or clusters display the most prosecuted firms and sectors? These questions are stimulated by an interest in ‘assemblage geography’ and evolutionary spatial analysis; accordingly, financial ‘dark’ clusters are proposed for study in this contribution. Assemblage connections may be hypothesised to be found in financial districts that replicate Marshallian proximity, notably Delaware in the US (Weitzman, 2022). That state specifically and its main city, Wilmington, is proposed as an exemplary rising agglomeration of relational interactions specialising in US tax avoidance and bankruptcy. In Switzerland, Bellinzona Federal Criminal Court recently hosted a Swiss Bank’s first-ever domestic trial for criminality in the shape of Credit Suisse. This bank had a fine of SFr2mn imposed on the bank, which was also ordered to pay €18.6mn in compensation to the Swiss government. An extra penalty was imposed by confiscation of SFr12 mn in criminal assets from the convicted perpetrators. The case had involved a group of Bulgarian clients laundering cocaine profits between 2004 and 2008 involving huge sums of cash being brought to the bank in suitcases, further associated with two assassinations. These red flags were missed by a bank which had received multiple fines elsewhere (Carrel, 2022). In reference to gang crime, in 2004, a Credit Suisse banker in Tokyo was arrested for allegedly helping launder at least ¥5bn linked to Japan’s largest Yakuza gang connected in a Japan, Switzerland and Hong Kong network (Makortoff and Pegg, 2022). Regarding the demise of Switzerland’s second global bank, after being badly hit by the huge Greensill and Archegos bankruptcies Credit Suisse was bailed out for £45 billion by the Swiss Central Bank in March 2023. Earlier, in 2015–2017, Disney, the creative economy exemplar in this narrative, is profiled in our third vignette as an imperious tax-dodging ‘fiefdom’ yet surviving as the global mass-entertainment leader. Finally, in sections 4 and 5, we profile two London-centred banking ‘scandals’ with ‘sustainability’ rather than ‘creative’ overtones. Thus of dubious banking practices London’s many categories of financial regulator are served by two ‘assemblage’ cases that will be analysed subsequent to being advanced as candidates. One recent exemplar is Balli Steel, an Anglo-Iranian sanctions-breaker, while another is Britishvolt, a financially failed EV gigafactory project in the UK.

Re-consideration of Lymph Node Metastasis in Pancreatic Cancer Patients Following Radical Resection: A Retrospective Study.

Perioperative chemotherapy has become more common in patients with pancreatic cancer (PC), and the significance of lymph node (LN) metastasis and the role of surgical resection in PC have gradually evolved. In the present study, we reconsidered the significance of LN metastasis for patients with PC. We analyzed 142 PC patients who underwent radical resection at our hospital between September 2012 and December 2021. Patients were divided into three groups based on the performance of preoperative chemotherapy, as follows: up-front surgery (US, n=109), neoadjuvant chemotherapy (NAC, n=22), and conversion surgery (CS, n=11). The characteristics of patients with LN metastasis in the US group were clarified, and a prognostic analysis was performed. The prognostic impact of LN metastasis in the NAC/CS group was examined and compared to that in the US group. Multivariate analysis revealed that high CA19-9 levels, large tumor size, and positive lymphatic invasion were significantly associated with LN metastasis. LN metastasis and portal vein invasion were independent poor prognostic factors in multivariate analysis. Patients without LN metastasis in the NAC group tended to have a better prognosis than those in the US group; however, the prognosis of patients with LN metastasis was similar between the two groups. In the CS and US groups, the prognosis was comparable for patients with and without LN metastasis. LN metastasis is a notably poor prognostic factor for PC patients, even after NAC, and more aggressive perioperative treatments may be considered for these patients.

Comparative efficacy of stannous fluoride and zinc sulfate solution to copper sulfate footbath solutions for the treatment and prevention of digital dermatitis in lactating dairy cows

The objective of this study was to determine whether a novel footbath solution containing stannous fluoride (SnF2) was superior to 5% copper sulfate solution for the treatment and prevention of digital dermatitis (DD) in dairy cattle. Study 1 was conducted over 4 weeks in Missouri and involved 34 lactating Holstein-Friesian cows with hind feet DD lesions. Cows in group SF walked through a footbath containing a proprietary formulation of SnF2 once weekly, whereas cows in group CS walked through a 5% CuSO4 footbath once daily for 5 d each week. Study 2 was conducted over 8 weeks in California and involved 40 lactating Holstein-Friesian cows with hind feet DD lesions. Cows in group SF walked through a SnF2 footbath for 3 consecutive days then once a week for the following 7 weeks. Cows in group CS walked through a 5% CuSO4 footbath 3 times each week for 8 weeks. Data collection included lesion type, lesion area, locomotion score, and pain score. Digital dermatitis was actively transmitted in study 1, and lesion area and locomotion scores were lower in group SF than group CS. In contrast, DD was not actively transmitted in study 2, and lesion area and locomotion scores were similar in groups SF and CS. Stannous fluoride delayed the development of active DD lesions in study 1 compared with copper sulfate, with a lower relative risk (0.57, P < 0.001) of a hind foot developing an active DD lesion over 28 d. However, SnF2 decreased the rate that active DD lesions transitioned to M3, M4, or M0 lesions compared with 5% copper sulfate in both studies, with the relative risk of a hind foot with an active DD lesion transitioning to M3, M4, or M0 in group SF being slightly lower in study 1 (0.83, P = 0.042) and study 2 (0.90, P = 0.020) than group CS. Our findings demonstrated that walking cows through a stannous fluoride footbath once per week in a herd undergoing active transmission of infection was more effective in preventing active DD lesions, but less effective in treating active DD lesions, than walking cows through a copper sulfate footbath 4 times per week. The novel SnF2 footbath solution shows promise for controlling DD in dairy herds that want an alternative footbath solution to CuSO4 and are interested in limiting the environmental accumulation of copper.

Breaking the chains of traditional finance: A taxonomy of decentralized finance business models

Recently, the looming bankruptcy of Credit Suisse, which ultimately led to its merger with UBS, has intensified the discussion surrounding the need for more transparent and democratic financial markets. Decentralized finance (DeFi) represents a departure from traditional financial intermediation by leveraging blockchain technology and smart contracts. Despite its growing importance, limited research has been conducted on the business models of DeFi services. This study aims to address this gap by examining the business models of various DeFi services, identifying key drivers of innovation, differentiation, and value creation. Using a rigorous taxonomy development framework, we identify 12 dimensions and 47 characteristics that operationalize business models in DeFi. Our findings contribute to a better understanding of the transformation of financial services through blockchain technology and provide valuable insights for DeFi entrepreneurs, investors, and policymakers.

Exploring functional metabolites and proteomics biomarkers in late-preterm and natural-born pigs.

Pigs are often used to study the intestinal development of newborns, particularly as preterm pig models that mimic the intestinal growth of human preterm infants. Neonatology's study of delivery mode's impact on neonatal development is crucial. We established 14 newborn pigs delivered via cesarean sections (C-section, at 113 days of gestational age, CS group) and 8 naturally born pigs were used as controls (at 114 days of gestational age, NF group). The impact of two alternative delivery procedures (C-section and natural birth) on the levels of short-chain fatty acids (SCFAs) and organic acids in the hepatic and intestines of newborn pigs were compared using metabolomics. The underlying molecular pathways are examined at the "protein-metabolite" level by integrating proteomic data. The findings demonstrated that the mode of delivery changed the metabolism of SCFAs in newborn pigs, perhaps by affecting the physiology levels of cyclic intermediates such as lactate and malate in the pyruvate metabolic pathway. Additionally, by participating in the fatty acid metabolism pathway, two distinct proteins (FASN and HSD17B4) may impact the physiological concentration of these tiny metabolites. In conclusion, this study provided reliable animal model data for understanding the physiological SCFA metabolic information and its affecting mechanism of large-gestational age preterm infants.