The possibility is considered that changes of spatial topology occur as tunneling events in quantum gravity. Creation of scalar and spinor particles during these tunneling transitions is studied. The relevant formalism based on the euclidean Schrödinger equation and coherent state representation is developed. This formalism is illustrated in a two-dimensional example. It is argued that the particle creation during the topological changes induces the loss of quantum coherence. The particle creation is calculated in the case of O(4)-invariant background euclidean four-dimensional metrics. This calculation is used for estimating the loss of quantum coherence. An upper limit on the rate of the topological changes, A⪅10 −17M Pl 4 , is derived from the observation of K 0− K 0 oscillations.