Cream Type Research Articles

The Effectiveness of Sunscreen Cream with Ethanol Extract of Sungkai Leaves (Peronema canescens Jack)

Sungkai (Peronema canescens Jack) (PCL) contains flavonoid compounds that can absorb UV light therefore having the potential to be developed as a raw material for cosmetics that functions as a sunscreen. The research aims to formulate PCL extract into a sunscreen cream. Sungkai leaves are macerated using 96% ethanol solvent. Specific and non-specific parameter tests were carried out on the extract as well as antioxidant tests using the DPPH method and SPF tests using the Mansur method. The results of this research showed that 96% ethanol extract of PCL had a blackish-green color, pH 5.25; the ethanol and water-soluble essence levels were 6.25% and 5.17%. The water content obtained is 27.4%; drying shrinkage is 0.46%; total ash content is 0.12% and acid insoluble ash content is 0.1%. The antioxidant value obtained was 35.06 ppm. Three cream formulations were prepared (FI of 0.1753%, FII of 0.3506%, and FIII of 0.5259%) and evaluated for organoleptic, homogeneity, cream type, viscosity, pH, particle size, and spreadability tests for one month at 25℃ and 40℃. The organoleptic test results of the cream have a soft texture, with varying colors; light green (FI), green (FII), and dark green (FIII) color. Other evaluation test results show that the cream has a pH of 5.16 - 6.73, a spreadability of 6.47 - 8.07 cm, a viscosity of 15466.67 - 38933.33 cPs, a particle size of 9.88 - 16.17 µm and an SPF of 17.68 (FI), 27.46 (FII), and 33.64 (FIII) with ultra protection on all three. PCL extract after being formulated into creams shows high SPF activity with F3 as the best formula. PCL extract can be formulated into a cream form that meets physical and chemical quality parameters.

ANTIBACTERIAL ACTIVITY TEST OF TEA TREE AND LEMON OIL COMBINATION AND ITS FORMULATION IN CREAM PREPARATION

Tea tree oil contains hydrocarbon compounds, namely terpenes, especially monoterpenes, sesquiterpenes, and alcohols. Terpinen-4-ol is the main component of tea tree oil, which has antimicrobial activity. Lemon oil is useful as an antibacterial because it contains flavonoids that prevent attacks from pathogenic bacteria. This study aims to determine whether tea tree and lemon oil have antibacterial activity against Propionibacterium acnes bacteria and can be formulated into cream preparations. The antibacterial activity test of the combination of tea tree oil and lemon oil in the 1: 1, 1: 2, and 2: 1 ratio was carried out in vitro against Propionibacterium acnes bacteria by disc diffusion method and using virile gel as a positive control. The cream stability test is replicated using the cycling test method with organoleptic test parameters, homogeneity, pH, dispersion, cream type testing, viscosity, and flow properties. The stability test results with the cycling test method showed good stability results, including organoleptic tests, homogeneity, spreadability, pH, emulsion type, viscosity, and flow properties. The combination of tea tree and lemon essential oils in a 1:1, 1:2, 2:1 ratio has antibacterial activity against Propionibacterium acnes bacteria with inhibition zones diameter ±1,23 cm, ±1,12 cm, and ±1,12 cm and control has ±1,53 cm. Combining tea tree and lemon essential oil in a 1:1, 1:2, and 2:1 ratio has antibacterial activity against Propionibacterium acnes bacteria and can be formulated into cream preparations. Keywords: tea tree oil, lemon oil, antibacterial, Propionibacterium acnes, cream.

Preparation and Evaluation of Aloe-Vera and Vitamin E Anti-aging cream

Aging is a natural progressive process that leads to aesthetic and functional changes in the skin. Premature aging is also observed at young age around 20 due to pollution, cigarette smoke, sunlight, effects of an unhealthy lifestyle, insufficient nutritional intake, and prolonged illness. The aim of this research work is to formulate and evaluate an herbal antiaging face cream using Aloe-Vera and Vitamin E. Radical scavenging activity of prepared cream was studied using DPPH method and standard ascorbic acid was used. The evaluation test like, Organoleptic Test, pH, viscosity, spreadability, phase separation, homogeneity test, cream type, Draize test and ease to removal test were carried out. The stability study over three week was also executed.

Physicochemical Characteristics and SPF Value of Kepok Banana Corm Extract Cream

Banana Corm is banana plant waste that has not been utilized optimally and contains flavonoids which have the potential as natural UV repellents. This study aims to determined the physical-chemical characteristics and preferences of respondents as well as the SPF value of kepok banana corm extract creams. Three cream formulations were carried out using concentration variants of 10% (F1), 20% (F2) and 30% (F3) with physical property tests including organoleptic tests, cream type tests, homogeneity tests, spreadability tests, centrifugation tests and SPF value. The test results show that the three formulations have different colors and aromas and are o/w cream types and have a homogeneous texture. All formulas meet the skin's pH range. In the test results there was a significant difference (p<0.05) in the order of highest spreading power in diameter F3 (5.725 ± 0.01 cm) × F2 (5.24 ± 0.2 cm) × F1 (5.24 ± 0.092 cm ), whereas for the centrifugation test results there was no phase separation in the supply. The results of respondents' preferences for cream showed that the overall cream preparation formula is acceptable and liked by respondents. Based on the research results, it can be concluded that the banana bongol extract cream meets the physical quality requirements based on predetermined parameters and the banana bongol extract cream can be accepted by respondents. Cream with variations in banana weevil concentration of 10%, 20% and 30%, obtained an SPF value in the maximum protection category

Preservative Efectiveness Test of Dry Water Extract of Gambier (Uncaria Gambir Roxb.) In Cream Type of Cosmetics

Gambier is an endemic plant that can grow properly such as in Indonesia it has been empirically used for natural coloring, antiinfection and burns wound healing. Gambier used as antimicrobials because its catechins compound. Catechins mechanism as antimicrobial are break the cell wall or cell membrane of bacteria, other mechanism is to precipitate of protein because the catechins properties is same with phenolic compound. This research aims to know the preservative effectivity of dry water extract of gambier (Uncaria gambir Roxb.) in cream type of cosmetics. Research methods are total plate count, yeast and mold count, logs and percentage of preservative effectivity test. The data of the result there are: gambier extract in Pseudomonas aeruginosa cream shows the preservative requirement at 2%, 2,5% and 3% concentrations with 100% of reduction and 3 logs reductions on 14th days testing; gambier extract in Staphylococcus aureus cream shows the preservative requirement at 3% concentrations with 100% of reduction and 3 logs reductions on 7th days of the test; gambier extract in Enterobacter aerogenes cream shows the preservative requirement at 2%, 2,5%, 3% and 3,5% concentrations with 100% of reduction and 3 logs reductions on 28th days of the test; gambier extract in Candida albicans cream shows the preservative requirement at 2%, 2,5% and 3% concentrations with 100% of reduction and 3 logs reductions on 7th days of the test; gambier extract in Aspergillus niger cream shows the preservative requirement at 2,5% and 3% concentrations with 100% of reduction and 3 logs reductions on 7th days of the test. Dry water extract of gambier has the potential that can be used as a microbial preservative in cream type of cosmetics

Uji Antioksidan Ekstrak Dan Formulasi Sediaan Krim Tabir Surya Kulit Delima Putih (Punica Granatum L.) Dengan Metode DPPH Dan Penentuan Nilai SPF

White Pomegranate (Punica granatum L.) is a plant that is efficacious as an antioxidant which functions as a natural antioxidant to prevent free radicals from harming the body because it contains flavonoid compounds including flavones and flavonols which are known as natural antioxidants. This study aims to determine the IC50 value of extracts and formulations of white pomegranate skin sunscreen cream (Punica granatum L.) along with its SPF value. The extract was prepared by maceration using 96% ethanol. Testing the antioxidant activity of white pomegranate peel extract (Punica granatum L.) using UV-Vis spectrophotometry with the DPPH method (1,1-Diphenyl-2-Picrylhyrdazyl), the test results showed that white pomegranate peel extract (Punica granatum L.) had an IC50 value of 92,76 ppm in the strong category. Sunscreen cream was made into four formulas, namely F0, FI, FII and FIII with extract concentrations of 5%, 10% and 15% respectively. The physical evaluation was tested, including organoleptic test, homogeneity test, cream type test, spreadability test, adhesion test, pH test, viscosity test and organoleptic stability test which showed that the four formulas met the requirements of the physical evaluation test for sunscreen cream preparations. The four sunscreen cream formulas, an antioxidant activity test was carried out using the DPPH method (1,1-Diphenyl-2-Picrylhyrdazyl) at F0, FI, FII and FIII and obtained IC50 values of 146,9 ppm (weak), 98,22 ppm (strong), 81,37 ppm (strong) and 76,88 ppm (strong). Determination of the SPF (Sun Protection Factor) value was carried out using the mansyur equation method using UV-Vis spectrophotometry at a wavelength of 290-320 nm. The results obtained for the SPF values in the four formulas F0, FI, FII and FIII were 6,02 (extra), 14,39 (maximum), 22,98 (ultra) and 27,60 (ultra).

Anti-Inflammatory Test of Topical Cream Preparations from Ethyl Acetate Fraction of Johar Leaves (Cassia siamea L.) in White Mice

Johar leaves contain chemical compounds, there are alkaloids, saponins, tannins, flavonoids, barracol, sitosterol. This study aims to determine the anti-inflammatory effect of the johar leaf ethyl acetate fraction topically, to determine the optimum concentration of johar leaf ethyl acetate fraction in cream preparations, and to determine the physical properties of the johar cream and cream stability. The leaves of johar (Cassia siamea L.) were extracted using the maceration method with 70% ethanol. The ethanol extract of johar leaves was fractionated with water, n-hexane and ethyl acetate as solvents. The ethyl acetate fraction of johar leaves was made cream with a concentration of 2.5%, 5% and 10%. The basis and the three formulas were tested for the physical quality of the cream including the organoleptic test, homogeneity, viscosity, spreadability, adhesion, cream type, pH and cream stability. The anti-inflammatory effect was determined by measuring the thickness of the back skin of the mice. The data obtained were analyzed statistically One Way Anova with a confidence level of 95% to determine that there were significant differences between treatment groups. The results showed that the leaf ethyl acetate fraction cream could provide topical anti-inflammatory effects on carrageenan-induced white mice with an effective concentration of 5% with (% PI) of 36.67%. The ethyl acetate fraction of johar leaves with a concentration of 2.5% and 5% fulfilled the requirements for the physical properties of the cream, but the cream with a concentration of 10% did not meet the requirements in the pH test. And the ethyl acetate fraction cream of johar leaves was stable in 1 month storage

Formulation of Blush On Cream from Hibiscus Sabdariffa (L.) Flower Extract

Natural dyes have become more popular as a result of the harmful and carcinogenic effects of syntheticdyes. Anthocyanins are natural dyes that are widely used to replace synthetic dyes and can also act asantioxidants that can be found in rosella (Hibiscus sabdarrifa L.). This study aimed to obtain blushon cream from rosella flower extract (RFE) with olive oil and to determine the effect of olive oilconcentration on the evaluation results. The blush on cream was made in 3 formula, F1 (13,5%),F2 (15,5%), and F3 (17,5%). The cream was evaluated for 28 days in room temperature (15–30⁰C)which included organoleptic, pH, homogeneity, spreadability, adhesion, cream type, and viscosity.The results of the evaluation of RFE blush on cream with olive oil showed that F1, F2, and F3 metthe requirements for evaluating the preparation for organoleptic tests, pH, homogeneity, spreadability,adhesion, cream type, and viscosity. Variations concentration of olive oil gave no significant effect(p>0,05) on the organoleptic, pH, homogeneity, spreadability, and cream type and had significant effect(p<0,05) on the adhesion and viscosity test. The findings demonstrate that RFE can be made in blushon cream formulations with olive oil as emollients.

Effect of the denture adhesive for dry mouth on the retentive force of the experimental palatal plates: a pilot controlled clinical trial

BackgroundA denture adhesive for dry mouth with good cleaning properties has recently been developed. While previous studies on models have shown the effectiveness of denture adhesives in terms of retention and cleanability, no reports have evaluated their effectiveness in the oral cavity. The aim of this study was to compare and investigate the retention and usability of an experimental palatal plate in the dentulous jaw using a denture adhesive for dry mouth, a conventional cream-type denture adhesive, an oral moisturizer, and a denture moisturizer.MethodsTen healthy dentulous participants (mean age 27.2 ± 1.6 years) were included in the study. Palatal plates were fabricated. Four test samples were used: denture adhesive for dry mouth, conventional denture adhesive (cream type), oral moisturizer, and denture moisturizer. The sample was applied to the inner surface of the palatal plates, and the retentive force of the palatal plate was measured every 10 min for 30 min. After the measurements, the study participants were asked to rinse the palatal plate with water and subjectively evaluate the samples used.ResultsThe conventional denture adhesive (cream type) showed increased retentive force over time, with the maximum retentive force obtained after 10 min of application. However, its washability was rated second lowest. The denture adhesive for dry mouth showed the highest retentive force immediately after application. Its washability was also good.ConclusionsThe results suggest that the denture adhesive for dry mouth has reasonable retentive force in the oral cavity and cleaning properties compared to the conventional cream-type denture adhesive.

Caracteristics of sunscreen from seaweed porridge (Turbinaria conoides) and galangal extract (Alpinia galangal)

Natural ingredients that have sunscreen activity, namely galangal (Alpinia galanga) have a role in absorbing UV rays. Seaweed (Turbinaria. conoides) contains alkaloids, tannins, antioxidants, fucoxanthin. Many cases of skin damage due to harmful cosmetic ingredients and exposure to UV rays have encouraged the authors to explore the natural wealth of seaweed and galangal into skin care products. The aim of the study was to determine the optimum formulation and evaluate the best characteristics of seaweed and galangal sunscreen cream preparations. This research was experimental with four treatments and three replications giving concentrations of seaweed and galangal F0 (control), F1(1:1), F2(1:2), F3(2:1). The tests carried out included hedonic, homogeneity, centrifugal, viscosity, SPF, humidity and pH tests. The hedonic results show significant differences in color parameters (F3). All treatments produced cream type (O/W) and were homogeneous, there was no phase change in the centrifugal test. The viscosity and pH values meet the requirements and can moisturize, the highest SPF value (F2) is 3.67 in the minimum category. The more addition of seaweed affects the color characteristics. The more galangal added, the higher the SPF. Of all the treatments, the formulation with the addition of seaweed and galangal affected the characteristics of the resulting cream.

Formulasi dan Uji Sifat Fisik Sediaan Krim dari Ekstrak Watermelon Rind ((Citrullus lanatus).(Thunb)).

Indonesia has a tropical climate which makes the body produce excess oil. This triggers the occurrence of acne, because it can clog skin pores and cause the formation of bacterial colonies. Watermelon is a fruit that has many health benefits. Generally, people consume the contents and throw away the white flesh and skin (watermelon rind), even though this part has good benefits for the skin because it contains several biochemical compounds that act as antibacterial. One of the preparations used for skin problems is cream. This study aims to produce a formula for the preparation of watermelon rind extract cream that complies with pharmaceutical requirements and is stable in storage. Watermelon rind cream preparation is made with a concentration of watermelon rind extract, namely FI 7.5%; FII 12.5%, and FIII 20%. Finished preparations were tested for physical stability which included organoleptic tests, homogeneity, pH, irritation tests, cream type tests, spreadability and stability tests. The watermelon rind extract cream obtained is green in color, has a distinctive smell of extract and rose oil, is homogeneous, and is of the M/A type. The pH of the watermelon rind extract cream is in a range that is still acceptable to the skin and has good spreadability and does not cause irritation to the skin. During the storage period, the watermelon rind extract cream did not experience physical changes and homogeneity, and did not experience a significant decrease in pH and spreadability with a p-value > 0.05. This shows that the preparation of watermelon rind extract cream meets pharmaceutical requirements and is stable during storage.

FORMULATION AND STABILITY TEST OF CREAM FROM JUICE OF BELIMBING WULUH (AVERRHOA BILIMBI l.)

Research on cream formulations using starfruit (Averrhoa bilimbi L.) juice has been carried out to determine the effect of sodium lauryl sulfate on the physical stability of cream from starfruit juice. Carambola wealth as an active substance is made in cream with varying concentrations of sodium lauryl sulfate of 1%, 1.5%, 2%, and 2.5%. The evaluation was carried out in the form of organoleptic tests, homogeneity, cream type, pH, viscosity, centrifugation, and freeze-thaw. Data analysis was carried out using statistical tests using ANOVA which has a 95% confidence level (α = 0.05), the test is continued with the Tukey HSD test, and the analysis results show significant differences in each formula. The research results concluded that the higher the concentration of sodium lauryl sulfate as an emulsifying agent, the physical stability of the viscosity of the cream from starfruit juice increased.

Aktivitas Antioksidan dan Tabir Surya Krim Ekstrak Biji Alpukat (Perseaamericana Mill.) dan Ekstrak Tongkol Jagung (Zea mays L.)

Antioxidants are substances that function to help overcome oxidative damage caused by free radicals or reactive oxygen compounds. Formation of free radicals in the body one of which is due to exposure to ultraviolet (UV) radiation. The formation of free radicals due to UV radiation can be overcome by using sunscreen. Avocado seeds and corn cobs are known to be rich in flavonoids which have the potential to be used as antioxidants and sunscreens. Both are wastes that have the potential to be utilized. This study aims to test and determine the antioxidant and sunscreen activities of five cream formulations containing a 1% mixture of avocado seed extract and corn cobs (0% : 1%, 0.25% : 0.75%, 0.5% : 0.5%, 0.75% : 0.25%, and 1% : 0%). Each formula was replicated five times. The preparation of each formula was evaluated including organoleptic (smell, color, and consistency) and homogeneity which was carried out by 25 panelists. Also tested for pH, spreadability, cream type, stability, antioxidant activity using the DPPH method and sunscreen activity (in vitro determination of SPF) on each formula. The organoleptic test results showed an orange cream with a characteristic odor and a semi-solid to a slightly liquid consistency. All cream formulas are homogeneous, the type of cream produced is oil in water type, physically stable cream, pH of all creams is 8, dispersion is 6-8cm, no antioxidant activity while sunscreen activity is minimal to moderate (value of SPF 3-5).

FORMULASI SEDIAAN CREAM DAN UJI AKTIVITAS ANTIBAKTERI PADA EKSTRAK ETANOL KOMBINASI KULIT PISANG (Musa paradisiaca) DAN KULIT NANAS (Ananas comosus) TERHADAP BAKTERI PENYEBAB JERAWAT Propionibacterium acnes

Background: Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis, involving sebaceous glands, follicular hyperkeratosis, bacterial overgrowth, immune and inflammatory responses. Objective: This formulate the ethanol extract of banana peel and pineapple peel into cream preparations and to test the effective antibacterial activity of the combination of banana peel and pineapple peel ethanol extract cream against Propionibacterium acnes. Methods: This research was conducted experimentally with maceration extraction using 70% ethanol as solvent. Acne cream is made with a concentration ratio between (Banana peel: Pineapple peel) namely F1 (Cream Base), F2 (5%:15%), F3 (7.5%:12.5%), F4 (10%:10% ), F5 (12.5%:7.5%), F6 (15%;5%), F7 (20%:0%) and F8 (0%;20%). Then, the physical stability test was carried out in the form of organoleptic test, viscosity test, pH test, homogeneity test, spreadability test and cream type test. Followed by testing the bacteria Propionibacterium acnes in Na media. Results: The antibacterial activity test on F3 showed that the diameter of 20.18 mm was relatively larger than F1 of 0mm, F2 of 18.63 mm, F4 of 18.38 mm, F5 of 16.48 mm, F6 of 18.28 mm, F7 of 13.91 mm and The F8 is 16.11 mm. Conclusion: Cream preparations from formula 1 to formula 8 the cream stability organoleptic test, viscosity test, pH test, homogeneity test, test spreadability and cream type test. The cream preparation in formula 3 has the widest diameter for antibacterial activity compared to other formulas.

Potential Effect of Black Cumin Honey on Skin Wrinkles, Pores, Moisture, and Sebum

Acne vulgaris is a chronic inflammation of the polysebaceous follicles with the presence of blackheads, papules, pustules, and cysts in predilection areas. The new drug development to provide more effective therapy of topical cream containing bioactive compounds has emerged. The properties possessed by black cumin and honey can be combined as a new anti-acne drug. This research aims to provide the skin evaluation data of modified topical cream of black cumin honey by following the guidelines of good manufacturing practice (GGMP). The organoleptic, pH, homogeneity, scatter power, cream type, and stability of combination cream have been tested. The the effectiveness of cream was evaluated based on the number of skin wrinkles, skin moisture content, number of skin pores, and sebum. Results showed that a combination cream of 5% extract has met the good standard of preparation. The topical application involving 40 volunteers within two weeks showed a significant effect on increasing the skin moisture and also reducing the skin wrinkles, pores, and sebum. This research showed the black cumin honey cream could improve skin conditions and potentially be used for topical antiacne treatment soon.

Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator

Black papper seed extract has known for its antivitiligo potential. The addition of black papper seed extract was predicted can influence the physical stability of the cream. Therefore, this research was aimed to test the physical stability of cream contained black papper seed extract in varity of emulgator there is tween® 60-span® 60, tween® 80-span® 80, novemer®, dan viscolam®. Physical stability test using the cycling test method by storing the preparation at 4 ° ± 2 ° C for 24 hours and then storing it at 40°±2°C) for 24 hours. The storage time at these two different temperatures is considered as one cycle and carried out for 12 days. The stability parameters were organoleptic observations, homogeneity, dispersion, pH, viscosity and cycling test results. The results showed that there were differences in organoleptic values, pH, viscosity, homogeneity and dispersibility. The most stable cream was obtained, namely the cream formula using emulgator Tween® 60-span® 60, had a good organoleptic value, cream type m/a, pH 5.10, viscosity 46,800 cPs, spreadability 4.2 cm2, homogeneous cream . The results of this study indicate that black pepper seed extract cream can be formulated into a stable cream preparation.

FORMULASI SEDIAAN KRIM EKSTRAK ETANOL KULIT BUAH KAKAO (Theobroma cacao L.) SEBAGAI ANTIOKSIDAN

Research has been carried out on the formulation of ethanol extract cream for cocoa pods (Theobroma cacao L.). The research was carried out at the Laboratory of the Faculty of Health Sciences, Jayapura University of Science and Technology, ± 3 months, namely March 5 - June 6, 2021. The purpose of the study was to determine the best formula for Ethanol Extract Cream for Cocoa Fruit Peel. The type of this research is descriptive method with laboratory experimental approaches. The population used in this study was the Cocoa Fruit Skin in Arso III Region, Keerom Regency. The number of samples in the study was 3 kg. The basic ingredients are taken from cocoa pods and the active ingredients are taken from maceration for 3×24 hours using70% ethanol as solvent. The formulation was carried out with variations of formulas I, II, and III with concentrations of stearic acid as an emulsifier, namely 6%, 9%, 12%. To get the best formula, an evaluation of the preparation was carried out including cream type testing, organoleptic testing, homogeneity testing, pH testing, dispersion testing, stability testing, and irritation testing. The results showed that the best formula was formula III with a concentration of 12% stearic acid with organoleptic evaluation test results showing a brown color, soft texture, homogeneous preparation, pH 6.3 and spreadability of 5 cm.

Formulasi dan Uji Aktivitas Antioksidan Krim Biji dan Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.) sebagai Body Scrub

Ethanol extract of guava leaf (Psidium guajava L.) contains flavonoids and tannins that are potentially as an antioxidant that may inhibit the activity of free radicals.The aim of this study is to formulate a body scrub cream from ethanol extract of guava leaf (Psidium guajava L.) and test their antioxidant activity.This study used three variations of concentration of ethanol extract 70% of guava leaf (Psidium guajava L.) i.e 1,5%, 2% and 2,5%.Body scrub creams are formulated into O/W type of creams by using guava seeds as a scrub.Evaluation of preparations included organoleptic examination, homogeneity, pH, cream type, stability test, particle size distribution, dispersion test and antioxidant activity test using DPPH method. The evaluation results showed that the physical properties of cream preparations provided good results and meet the requirements of cream preparations.The results of the antioxidant activity test found that the values of IC50 for each formula was F0 (without extract) 379,58 µg / mL, F1 (1,5%) 150,78 µg/mL, F2 (2%) 137,26 µg/mL and F3 (2,5%) 125,84 µg/mL.It can be concluded that body scrub creams of ethanol extract 70% of guava leaves (Psidium guajava L.) has the potential to be developed as a cosmetic preparation that can inhibit free radicals.

EKSTRAK ETANOL DAUN SUJI (Pleomele angustifolia) TERENKAPSULASI NANOPARTIKEL KITOSAN DALAM SEDIAAN KRIM TABIR SURYA DENGAN VARIASI TWEEN 80-SETIL ALKOHOL

ABSTRACTAntioxidants in the ethanolic extract of suji leaves (Pleomele angustifolia) have the potential as a sunscreen. The use of chitosan in the nanoparticle system is able to protect the degradation of flavonoids due to the influence of temperature and light. Tween 80 and cetyl alcohol play a strategic role in the formation of cream preparations. The purpose of this study was to determine the characteristics of sunscreen cream with variations of Tween 80-cetyl alcohol containing the active ingredient of ethanol extract of suji leaves encapsulated in a nanoparticle system. Chitosan nanoparticles of suji leaf ethanol extract (KEEDS) were prepared using ultrasonic agitation. KEEDS nanoparticles were made into cream preparations with variations of Tween 80-cetyl alcohol (T80:SA) FI (3:3)%, FII (3:10)%, FIII (10:10)%. The formed cream was observed for organoleptic, homogeneity, type of cream, and measured the value of pH, spreadability, adhesion, viscosity, and sunscreen activity using a UV-Vis Spectrophotometer at a wavelength of 290–320 nm. Organoleptic data, homogeneity, pH and cream type were analyzed descriptively, while the spreadability, adhesion, viscosity and sunscreen activity were analyzed using ANOVA with 95% confidence limit. KEEDS nanoparticle cream visually looks homogeneous, with a brownish white color, soft texture, and the aroma of suji leaves. The pH value of the preparation is 4.74-4.88, the type of cream is O/W. The variation of the T80:SA combination resulted in significant differences in the values of dispersion, adhesion, viscosity and sunscreen activity between the three formulas (sig < 0.05).Keywords: cetyl alcohol, chitosan, cream, leaves Suji (Pleomele angustifolia), sunscreen, Tween 80

Pengaruh Trietanolamin Dan Asam Stearat Terhadap Mutu Fisik Dan Stabilitas Mekanik Krim Sari Buah Tomat

Tomatoes contain lycopene which is an antioxidant. Antioxidant preparations can be made in the form of a cream with components of an oil phase, a water phase and an emulsifier. Emulsifiers that can be used are triethanolamine (TEA) and stearic acid. This study aims to determine the effect of triethanolamine and stearic acid as emulsifiers on the physical quality and mechanical stability of tomatoes extract cream. The use of triethanolamine and stearic acid with a ratio of 2%:5%; 3%:10%; 4%:15%. The test are the physical characteristics of tomatoes extract cream included organoleptic, homogeneity, cream type, pH, viscosity, spreadability, adhesion, protection and mechanical stability using the centrifugation method. The results of the phytochemical screening of tomatoes extract were positive for triterpenoids. The test results of the three cream formulas are odorless, semi-solid form, light orange to white color, homogeneous, cream type M/A, pH 5.25 - 6.26; viscosity 5,376 cP - 14,370 cP, spreadability 4 - 5,067 cm, adhesion 4 - 11.6 seconds, protection power 2 - 5.2 seconds. The three cream formulas did not undergo phase separation. The higher concentration of TEA and stearic acid had an effect on viscosity, pH value, adhesion, dispersibility and protection, but had no effect on organoleptic, homogeneity, cream type, and stability. tomatoes extract cream with a concentration of TEA:stearic acid 2%:5% gave the best physical quality.