Despite a series of active safety precautions have been adopted by railway passenger trains, train collision accident cannot be completely eliminated in service,resulting in serious casualties and huge economic losses once it happened. With the continuous increase of train speed, the train collision safety and relevant impact protections have been paid more attention, and numerous related explorations have been carried out by domestic and foreign scholars. This paper reviews recent advances in the passive safety of train collisions and impact biological damage of drivers and passengers. First, the train collision accidents at home and abroad in recent years are summarized, and the biological damage distributions of survivals in a certain train collision accident are analyzed. Secondly, the main research approaches of collision passive safety of trains are illustrated, including numerical simulation, experimental investigation, and theoretical analysis, while the response attitudes and derailment mechanisms during the train collision process are outlined. Thirdly, the research progress of the collision passive safety of trains are elaborated, in terms of the design and evaluation standards of vehicle crashworthiness, energy-absorbing structural design based on multistage energy dissipation, train structural crashworthiness design based on collision energy management. Finally, the impact biological damage of drivers and passengers in train collisions are emphasized, and the related protective measures of reducing the biological damage of drivers and passengers are presented. Through the above overview, some suggestions are put forward for further studies: i) the applicability of the existing crashworthiness standards for trains needs to be further explored under the increased train speed; ii) the theoretical study on train collision is still scarce, and the collision theory of high-speed train should be further developed; iii) how to effectively learn from and refer to the mature experience of the automobile collision still needs systematic and in-depth investigation; and iv) the design and evaluation method of train passive safety based on the impact biological damage of drivers and passengers should be explored.