Cranial Ewing's Sarcoma Research Articles

Intracranial Ewing sarcoma with obstructive hydrocephalus in pediatric patient: a rare case report

Link of Video Abstract: https://youtu.be/b4jB7Jos8tw Background: Ewing’s sarcoma is the second most common primary bone tumor presenting in childhood and adolescence. Ewing's sarcoma of the skull bones is an unusual occurrence (6 to 9% of all Ewing’s. sarcoma cases). Here, we present a rare case of Ewing's sarcoma involving the central nervous system (CNS) in a 13-month-old child and share our experience with its management. Case Presentation: We report a case of a 13-month-old girl with a chief complaint of gradually progressive head size. There is a history of seizures once a week before admission. The head CT scan with contrast administration revealed non-communicating hydrocephalus with bone defect in the occipital region and an intraaxial tumor of the posterior fossa due to Ewing’s sarcoma. Conclusion: Primary cranial Ewing's sarcoma of the cranium is a rare occurrence; its extension to intraparenchymal is even rare. This diagnosis can be considered in the differential diagnosis in children with a tumor involving the skull with destruction of the bone.

Conundrum of Cranial Ewing’s Sarcoma: Facts to Consider

ABSTRACT Peripheral primitive neuroectodermal tumor of cranium or primary cranial Ewing’s sarcoma (ES) is an isolated phenomenon. So far, <100 cases are documented. The literature revealed good outcomes in favor of cranial ES due to less chances of distant metastasis; however, standardized treatment strategy is yet to developed. Here, we depicted the aggressive course of cranial ES by reporting the same in an 18-year-old young boy having right-sided scalp swelling of the 10-month duration. Despite providing combined modalities of treatment, the young boy departed his life with a short time of 12 months after diagnosis. Our case revealed the importance of early diagnosis in cranial ES. Strong emphasis should be given to employ different therapeutic approaches at the right time. Combination chemotherapy should be started as early possible and adjuvant radiotherapy is always recommended in subtotal resection. More case studies in future will also guide about independent prognostic markers of cranial ES.

Cranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors: A Retrospective Study Focused on Prognostic Factors and Long-Term Outcomes.

Purpose: Cranial Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumors (pPNETs) are rarely reported because of their extremely low incidence, and the current understanding of these tumors is poor. The purpose of this study was to illustrate the clinical, radiological, and pathological features of cranial ES/pPNETs and to discuss prognostic factors by survival analysis.Methods: A total of 31 patients who were pathologically diagnosed with cranial ES/pPNETs between 2000 and 2019 were enrolled in this study. To identify which parameters were associated with higher progression-free survival (PFS) and overall survival (OS) rates, univariate and multivariate analyses were performed.Results: The mean follow-up period was 24.8 months (range, 1–109 months). Eighteen (58.1%) patients had local recurrence and seven (22.6%) patients had distant metastasis. The results of the univariate analysis suggest that the extent of resection and adjuvant radiotherapy are potential prognostic factors for PFS and OS. Adjuvant chemotherapy was associated with OS (P = 0.027) but not with PFS (P = 0.053). The multivariate analysis revealed that the extent of resection and adjuvant radiotherapy were independent prognostic factors for both PFS and OS. In addition, metastasis was an adverse prognostic factor for OS.Conclusions: Surgical management plays a crucial role in the treatment of cranial ES/pPNETs, and gross total resection should be striven for whenever possible. Post-operative radiotherapy is highly recommended to improve PFS and OS. This study also confirms that metastasis is an adverse prognostic factor for cranial ES/pPNETs.

Primary Ewing sarcoma of squamous temporal bone with intracranial extension: a case report

Abstract Primary Cranial Ewing sarcoma (ES) is rare and that of temporal bone is even rarer entity. Only a few sporadic cases have been reported and no such case has been reported from Eastern India In this report we describe a case of 18 yrs old male with primary cranial ES of squamous temporal bone involving intracranial and extracranial compartment. The patient presented with swelling in zygomatic fossa and imaging studies showed a mass originating in the right temporal bone. Gross total resection of the tumor was done and sent for histopathological study. The case was referred for radio-chemotherapy and had no recurrence up to eight months of follow up.

The cell of origin of cranial Ewing's sarcoma: the dilemma persists

The cell of origin of cranial Ewing's sarcoma: the dilemma persists

About the article “Primary Ewing’s sarcoma of cranial bones: analysis of ten patients” by Pravin Shashikant Salunke et al. Can we tell the exact origin of cranial Ewing's sarcoma?

About the article “Primary Ewing’s sarcoma of cranial bones: analysis of ten patients” by Pravin Shashikant Salunke et al. Can we tell the exact origin of cranial Ewing's sarcoma?

Sarcome d'ewing du rocher

Introduction : Primary cranial Ewing's sarcoma is rare. This tumor was first described in 1921, since then, only a few cases have been reported in the literature.Aim: the aim of this study is to report the clinical and therapeutic aspects of primary cranial Ewing's sarcoma.Method: We report a case of Ewing's sarcoma of the temporal bone in a 16 months child diagnosed and treated in our department of ENT of Tunis.Result: the diagnostic of Ewing's sarcoma was made after bleeding ear. Histological confirmation was made following biopsy. After neoadjuvant chemotherapy, the tumor was surgically excised and the patient underwent chemotherapy. Neither recurrence nor distant metastasis was noted a 34 months.Conclusion: Although the prognosis of Ewing's sarcoma in general is often poor because of early metastasis to the lungs and/or to other bones, the same tumor occurring in the cranium can often be successfully managed by intensive therapy with radical excision and radiochemotherapy.Keywords: Ewing's; head and neck; Sarcoma; children

Primary cranial Ewing's sarcoma

Primary Ewing's sarcoma of the cranium is extremely rare, with only 17 cases reported so far. We describe a further case with involvementofthe frontotemporalregion and the orbit. The patient, an adult male, was admitted with headache and papilloedema, and later developed localised swelling and proptosis. He was treated with surgery, radiotherapy and chemotherapy, and was free from metastases during a follow-up of 14 months. The prognosis of Ewing's sarcoma is improving with radiotherapy and chemotherapy. Further cases are needed to study the biological behaviour of primary cranial Ewing's sarcoma.

Ewing's Sarcoma of the Zygomatic Bone: CT Appearance

Ewing's sarcoma of the zygomatic bone: CT appearance Ewing's sarcoma is a highly malignant tumor of uncertain origin. Primary cranial Ewing's sarcoma is exceptionally rare. Only eleven cases of such a tumor had been reported in the literature. This case represents the first reported instance of Ewing's sarcoma of the zygomatic bone. [Journal of Turgut Ozal Medical Center I(4):308-309,1994] Key Words: Ewing's sarcoma, computed tomography, zygomatic hone

Primary Ewing's sarcoma of the temporal bone

Primary cranial Ewing's sarcoma is exceptionally rare. Only ten cases of such a tumor had been reported heretofore in the literature. We describe a case of primary Ewing's sarcoma occurring in the temporal bone. The tumor was surgically excised, and the patient underwent radiation and chemotherapy. Neither recurrence nor distant metastasis was noted at 12 months after surgery. Although the prognosis of Ewing's sarcoma in general is often poor because of early metastasis to the lungs and/or to other bones, a review of the literature suggested that the same tumor occurring in the cranium can often be successfully managed by intensive therapy with radical excision and radiochemotherapy. This inference was supported by the case reported here.