Indaziflam is an alkylazine herbicide that controls annual grasses by inhibiting cellulose biosynthesis. Compared with other PRE herbicides like prodiamine, indaziflam has a longer half-life in soil (> 150 d), which may allow for greater flexibility with application timing. Research was conducted in 2010 in Tennessee and Georgia evaluating smooth crabgrass control efficacy with indaziflam applied at early PRE, PRE, and early POST timings on the basis of soil temperature. Regardless of application timing, all rates of indaziflam (35, 52.5, and 70 g ai ha−1) controlled smooth crabgrass 89 to 100%. Prodiamine at 840 g ai ha−1applied PRE provided ≥ 99% smooth crabgrass control on all rating dates. Smooth crabgrass plant counts were significantly correlated (r= −0.961; p < 0.0001) with visual ratings of smooth crabgrass control at the end of the study. Application flexibility with indaziflam may benefit turf managers in scheduling herbicide applications for smooth crabgrass control in Tennessee and Georgia.