Carbide-dispersion strengthened (CDS) vanadium alloy is a kind of advanced structural material for V/Li fusion blanket. The welding technology for the alloy is very important for its application in fusion reactors. In the present study, preliminary investigation on dissimilar-metal bonding by hot isostatic pressing (HIP) was carried out for the CDS V alloy by joining with the conventional V–4Cr–4Ti alloy. Microstructural characterization for the bonding interfaces and mechanical tests for bonding property evaluation were analyzed for the HIP joint. The results show that after the HIP, the grain size of the V–4Cr–4Ti base metal (BM) obviously increases, while the grain size near the interface is much smaller than that in the V–4Cr–4Ti BM. This is the reason why the hardness near the interface is larger than that of the V–4Cr–4Ti BM. By shear test evaluation, the HIP joint possesses good bonding property with sound strength and ductility. Because there is no phase transformation during HIP, no post-bond heat treatment (PBHT) is necessary for the dissimilar-metal joint.