Background: Cardiovascular disease is one of the common public health problems in the world. The cardiac arrest individual needs immediate rescue care (CPR) to support and maintain breathing and circulation. The public and non-medical professionals lack awareness and skill in performing CPR may leads to withdrawal and faulty CPR technique. Aim: The aim of the present study was to assess the effectiveness of Basic life support training on knowledge and skill of cardio-pulmonary resuscitation among class IV employees and compare the knowledge and skill with their demographic variables. Methods: A quasi experimental study, pre-test and post-test design with control group approach was conducted among 30 Class IV employees working in Pravara Rural Hospital, Loni. The class IV employees above 18 years were selected using simple random sampling. Data was collected by pre designed structured questionnaire and checklist. The results were analyzed using descriptive (percent, mean and SD), inferential statistics (paired “t” test and Chi square test). Results: The result revealed that there was an improvement in the knowledge on CPR (pre-test mean score 11.93±2.79 and post test score was 16.97±3.43, with effectiveness of 16.8%. The difference between the scores was significant ‘t’= 11.39 at 0.05 level. The participants exhibited partially adaptive skill on CPR with mean score of 13.4±3.12, scores range from 1 to 20. The socio demographic variables like age and area of work were significantly associated with knowledge, and age was significantly associated with skill on CPR (P<0.05). Conclusion: After the basic life support training there is a significant improvement in knowledge and skill on CPR by the class IV employees. This training can be used as standardized protocol for training the lay person on CPR which significantly contributes in reduction of mortality and morbidity.