This study aimed to determine the degree of knowledge, perception, and acceptance of the COVID-19 vaccine and to investigate the predictors of the willingness to accept the COVID-19 vaccine at the Aikmel Health Center. This cross-sectional study was conducted by distributing questionnaires to people who visited the Aikmel Public Health Center in July-August 2021, and 110 respondents were selected. A validated self-administered questionnaire was used for data collection. Descriptive statistics were used to analyze participants’ characteristics, knowledge, perception, and acceptance of the COVID-19 vaccine. Data were analyzed using Chi-Square and Binary Logistic Regression. It was found that 80.8% of respondents had good knowledge, 54.8% had positive perceptions, and 55.8% had high acceptance of the COVID-19 vaccine. There was a significant correlation between knowledge (p=0.035) and perception (p=0.000) with the acceptance of the COVID-19 vaccine. Predictors of the COVID-19 vaccine acceptance included having a positive perception of the vaccine (odds ratio [OR] 27,578) and having a history of COVID-19 vaccination (OR=3.999) with a CI of 95%. Knowledge about COVID-19 was good. Moreover, the perception and acceptance of the COVID-19 vaccine was more than half. Educational interventions are needed to reduce misperceptions and increase public acceptance of the COVID-19 vaccine.
 Keywords: COVID-19, vaccine, knowledge, perception, acceptance