Italy is the second exposed Country worldwide, after China, and Lombardia is the most affected Region in Italy, with more than half of the National cases, with 13% of whom being healthcare professionals. The Clinica Pediatrica Universita degli Studi di Milano Bicocca is a General Pediatric and Hematology Oncology and Transplant Center embedded within the designated COVID-19 general Hospital San Gerardo in Monza, located in Lombardia, Italy. Preventive and control measures specifically undertaken to cope with the emergency within Hemato-Oncology, Transplant, and Outpatient Unit in the Pediatric Department have been described. Preliminary COVID-19 experiences with the first Italian pediatric hemato-oncology patients are reported. The few available data regarding pediatrics and specifically hemato-oncological patients are discussed. The purpose of this report is to share pediatric hemato-oncology issues encountered in the first few weeks of the COVID-19 outbreak in Italy and to alert healthcare professionals worldwide to be prepared accordingly. Funding Statement: No funding. Declaration of Interests: The authors declare no competing interests.